Explore studies of bpc 157.
BPC 157 prevented liver necrosis and fatty changes in bile duct ligation, restraint stress, and CCl4 models. Effective orally and intraperitoneally. Outperformed bromocriptine, amantadine, and somatostatin.
Sikiric, P; Seiwerth, S; Grabarevic, Z; Rucman, R; Petek, M; Rotkvic, I; Turkovic, B; Jagic, V; Mildner, B; Duvnjak, M · Animal Study
BPC 157 from gastric juice shows broad organoprotection across multiple stress models. The stomach may initiate a body-wide protective response during stress via peptide mediators.
Sikirić, P; Petek, M; Rucman, R; Seiwerth, S; Grabarević, Z; Rotkvić, I; Turković, B; Jagić, V; Mildner, B; Duvnjak, M · Review
BPC 157 was the only tested compound that consistently protected against gastric and duodenal ulcers in all three models, regardless of whether given before, during, or after ulcer induction.
Sikiric, P; Seiwerth, S; Grabarevic, Z; Petek, M; Rucman, R; Turkovic, B; Rotkvic, I; Jagic, V; Duvnjak, M; Mise, S · Animal Study
BPC-157 provided strong gastroprotection against four distinct injury types (stress, ethanol, NSAID, capsaicin neurotoxicity), suggesting a broad protective mechanism involving sensory nerve pathways.
Sikirić, P; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Gjurasin, M; Konjevoda, P; Separović, J; Ljubanović, D; Artuković, B; Bratulić, M; Tisljar, M; Jurina, L; Buljat, G; Miklić, P; Marović, A · Animal Study
BPC-157 demonstrated both prophylactic and therapeutic effects in bile duct ligation-induced pancreatitis, also improving concomitant gastric and duodenal lesions.
Sikirić, P; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Jurina, L; Konjevoda, P; Hanzevacki, M; Ljubanović, D; Separović, J; Gjurasin, M; Bratulić, M; Artuković, B; Jelovac, N; Buljat, G · Animal Study
BPC-157 protected against lesions from both NO agonists and NO antagonists, suggesting a modulatory rather than one-directional effect on nitric oxide signaling.
Grabarevic, Z; Tisljar, M; Artukovic, B; Bratulic, M; Dzaja, P; Seiwerth, S; Sikiric, P; Peric, J; Geres, D; Kos, J · Animal Study
BPC-157 at 10 µg/kg provided dose-dependent protection against capsaicin-induced rhinitis, reducing mast cell infiltration, degranulation, and inflammatory cell accumulation.
Kalogjera, L; Ries, M; Baudoin, T; Ferencic, Z; Trotic, R; Pegan, B · Animal Study
BPC-157 enhanced all three major healing processes: granulation tissue formation, angiogenesis, and collagen synthesis.
Seiwerth, S; Sikiric, P; Grabarevic, Z; Zoricic, I; Hanzevacki, M; Ljubanovic, D; Coric, V; Konjevoda, P; Petek, M; Rucman, R; Turkovic, B; Perovic, D; Mikus, D; Jandrijevic, S; Medvidovic, M; Tadic, T; Romac, B; Kos, J; Peric, J; Kolega, Z · Animal Study
BPC-157 both protected against NSAID-induced GI lesions and improved chronic adjuvant arthritis, demonstrating simultaneous gastroprotective and anti-inflammatory effects.
Sikiric, P; Seiwerth, S; Grabarevic, Z; Rucman, R; Petek, M; Jagic, V; Turkovic, B; Rotkvic, I; Mise, S; Zoricic, I; Konjevoda, P; Perovic, D; Simicevic, V; Separovic, J; Hanzevacki, M; Ljubanovic, D; Artukovic, B; Bratulic, M; Tisljar, M; Rekic, B; Gjurasin, M; Miklic, P; Buljat, G · Animal Study
BPC-157 demonstrated cytoprotective effects in totally gastrectomized (acid-free) rats, proving its mechanism is independent of acid reduction.
Sikirić, P; Mikus, D; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Perić, J; Konjevoda, P; Perović, D; Jurina, L; Hanzevacki, M; Separović, J; Gjurasin, M; Jadrijević, S; Jelovac, N; Miklić, P; Buljat, G; Marović, A · Animal Study
BPC-157's mucosal protection in stress involves interactions with both adrenergic and dopaminergic neurotransmitter systems.
Sikirić, P; Mazul, B; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Jurina, L; Konjevoda, P; Hanzevacki, M; Gjurasin, M; Separović, J; Ljubanović, D; Artuković, B; Bratulić, M; Tisljar, M; Miklić, P; Sumajstorcić, J · Animal Study
BPC-157 counteracted both L-NAME (NO blocker) and L-arginine (NO donor) effects on gastric mucosa and blood pressure, confirming its role as an NO system modulator.
Sikirić, P; Seiwerth, S; Grabarević, Z; Rucman, R; Petek, M; Jagić, V; Turković, B; Rotkvić, I; Mise, S; Zoricić, I; Konjevoda, P; Perović, D; Jurina, L; Separović, J; Hanzevacki, M; Artuković, B; Bratulić, M; Tisljar, M; Gjurasin, M; Miklić, P; Stancić-Rokotov, D; Slobodnjak, Z; Jelovac, N; Marović, A · Animal Study
BPC-157 blocked acute amphetamine-induced stereotypy and prevented haloperidol-induced dopamine supersensitivity to amphetamine, without affecting normal baseline behavior.
Jelovac, N; Sikirić, P; Rucman, R; Petek, M; Perović, D; Konjevoda, P; Marović, A; Seiwerth, S; Grabarević, Z; Sumajstorcić, J; Dodig, G; Perić, J · Animal Study
BPC-157 attenuated catalepsy and gastric ulcers induced by haloperidol, fluphenazine, and reserpine at both 10 μg/kg and 10 ng/kg doses, demonstrating broad protective effects against neuroleptic side effects.
Jelovac, N; Sikiric, P; Rucman, R; Petek, M; Marovic, A; Perovic, D; Seiwerth, S; Mise, S; Turkovic, B; Dodig, G; Miklic, P; Buljat, G; Prkacin, I · Animal Study
BPC-157 co-administration with chronic diazepam (10 days) prevented tolerance development, maintained anticonvulsant efficacy, and reduced withdrawal seizure severity at both 10 μg/kg and 10 ng/kg doses in rats.
Jelovac, N; Sikiric, P; Rucman, R; Petek, M; Perovic, D; Marovic, A; Anic, T; Seiwerth, S; Mise, S; Pigac, B; Duplancie, B; Turkovic, B; Dodig, G; Prkacin, I; Stancic-Rokotov, D; Zoricic, I; Aralica, G; Sebecic, B; Ziger, T; Slobodnjak, Z · Animal Study
BPC-157 significantly attenuated alloxan-induced gastric lesions in rats (200 mg/kg SC) and mice (400 mg/kg IP), reducing lesion severity and accelerating healing over the observation period.
Petek, M; Sikiric, P; Anic, T; Buljat, G; Separovic, J; Stancic-Rokotov, D; Seiwerth, S; Grabarevic, Z; Rucman, R; Mikus, D; Zoricic, I; Prkacin, I; Sebecic, B; Ziger, T; Coric, V; Turkovic, B; Aralica, G; Rotkvic, I; Mise, S; Hahn, V · Animal Study
BPC-157 promoted segmental bone defect healing in rabbits with osteogenic activity comparable to IGF-1 and TGF-beta, demonstrating significant bone regeneration through angiogenic and osteoblast-stimulating mechanisms.
Sebecić, B; Nikolić, V; Sikirić, P; Seiwerth, S; Sosa, T; Patrlj, L; Grabarević, Z; Rucman, R; Petek, M; Konjevoda, P; Jadrijević, S; Perović, D; Slaj, M · Animal Study
BPC-157 attenuated both MPTP- and haloperidol-induced Parkinson's-like symptoms in mice while simultaneously protecting against gastric lesions caused by these parkinsongenic agents.
Sikiric, P; Marovic, A; Matoz, W; Anic, T; Buljat, G; Mikus, D; Stancic-Rokotov, D; Separovic, J; Seiwerth, S; Grabarevic, Z; Rucman, R; Petek, M; Ziger, T; Sebecic, B; Zoricic, I; Turkovic, B; Aralica, G; Perovic, D; Duplancic, B; Lovric-Bencic, M; Rotkvic, I; Mise, S; Jagic, V; Hahn, V · Animal Study
BPC-157 provided long-lasting cytoprotection lasting days after administration in gastrectomized rats with duodenal ulcers and reflux esophagitis, significantly outlasting ranitidine and sucralfate.
Sikiric, P; Jadrijevic, S; Seiwerth, S; Sosa, T; Deskovic, S; Perovic, D; Aralica, G; Grabarevic, Z; Rucman, R; Petek, M; Jagic, V; Turkovic, B; Ziger, T; Rotkvic, I; Mise, S; Zoricic, I; Sebecic, B; Patrlj, L; Kocman, B; Sarlija, M; Mikus, D; Separovic, J; Hanzevacki, M; Gjurasin, M; Miklic, P · Animal Study
BPC-157 promoted significantly more angiogenesis and granulation tissue formation than H2-blockers, omeprazole, or sucralfate, identifying its primary healing mechanism as enhanced new tissue growth rather than acid suppression.
Sikiric, P; Separovic, J; Anic, T; Buljat, G; Mikus, D; Seiwerth, S; Grabarevic, Z; Stancic-Rokotov, D; Pigac, B; Hanzevacki, M; Marovic, A; Rucman, R; Petek, M; Zoricic, I; Ziger, T; Aralica, G; Konjevoda, P; Prkacin, I; Gjurasin, M; Miklic, P; Artukovic, B; Tisljar, M; Bratulic, M; Mise, S; Rotkvic, I · Animal Study
BPC-157 demonstrates tissue-protective and regenerative effects across gastrointestinal, musculoskeletal, neurological, and cardiovascular systems, consistently accelerating healing through angiogenesis, anti-inflammation, and NO modulation.
Sikiric, P · Review
BPC-157 maintained cytoprotective activity even when prostaglandin synthesis was blocked by indomethacin, unlike standard anti-ulcer agents, indicating prostaglandin-independent protective mechanisms for adaptive cytoprotection against endogenous irritants.
Sikirić, P; Seiwerth, S; Desković, S; Grabarević, Z; Marović, A; Rucman, R; Petek, M; Konjevoda, P; Jadrijević, S; Sosa, T; Perović, D; Aralica, G; Turković, B · Animal Study
Complete dopamine system failure (combined haloperidol + reserpine) produced severe gastric lesions. BPC-157 provided superior healing compared to ranitidine, atropine, and other agents while also reducing associated catalepsy.
Sikiric, P; Separovic, J; Buljat, G; Anic, T; Stancic-Rokotov, D; Mikus, D; Duplancic, B; Marovic, A; Zoricic, I; Prkacin, I; Lovric-Bencic, M; Aralica, G; Ziger, T; Perovic, D; Jelovac, N; Dodig, G; Rotkvic, I; Mise, S; Seiwerth, S; Turkovic, B; Grabarevic, Z; Petek, M; Rucman, R · Animal Study
BPC-157 showed antidepressant activity in both the Porsolt forced swim test (reduced immobility) and chronic unpredictable stress model in rats, with effects comparable to established antidepressants.
Sikiric, P; Separovic, J; Buljat, G; Anic, T; Stancic-Rokotov, D; Mikus, D; Marovic, A; Prkacin, I; Duplancic, B; Zoricic, I; Aralica, G; Lovric-Bencic, M; Ziger, T; Perovic, D; Rotkvic, I; Mise, S; Hanzevacki, M; Hahn, V; Seiwerth, S; Turkovic, B; Grabarevic, Z; Petek, M; Rucman, R · Animal Study
BPC-157, omeprazole, and bromocriptine healed haloperidol-induced gastric lesions, while atropine, lansoprazole, and cimetidine failed, demonstrating the lesions are dopamine-mediated and BPC-157 acts through dopaminergic mechanisms.
Bilic, I; Zoricic, I; Anic, T; Separovic, J; Stancic-Rokotov, D; Mikus, D; Buljat, G; Ivankovic, D; Aralica, G; Prkacin, I; Perovic, D; Mise, S; Rotkvic, I; Petek, M; Rucman, R; Seiwerth, S; Sikiric, P · Animal Study
Topical BPC-157 cream accelerated burn wound healing (faster re-epithelialization and contraction) while simultaneously attenuating distant burn-associated gastric lesions in mice, demonstrating both local and systemic effects from topical application.
Mikus, D; Sikiric, P; Seiwerth, S; Petricevic, A; Aralica, G; Druzijancic, N; Rucman, R; Petek, M; Pigac, B; Perovic, D; Kolombo, M; Kokic, N; Mikus, S; Duplancic, B; Fattorini, I; Turkovic, B; Rotkvic, I; Mise, S; Prkacin, I; Konjevoda, P; Stambuk, N; Anic, T · Animal Study
BPC-157 provided sustained chronic cytoprotection against alcohol-induced gastric lesions, with effectiveness maintained throughout prolonged alcohol exposure alongside liver protection documented in companion study.
Prkacin, I; Aralica, G; Perovic, D; Separovic, J; Gjurasin, M; Lovric-Bencic, M; Stancic-Rokotov, D; Ziger, T; Anic, T; Sikiric, P; Seiwerth, S; Staresinic, M; Mise, S; Rotkvic, I; Jagic, V; Rucman, R; Petek, M; Turkovic, B; Marovic, A; Sjekavica, I; Sebecic, B; Boban-Blagaic, A; Ivasovic, Z · Animal Study
BPC-157 both prevented (when co-administered) and reversed (when given after damage) chronic alcohol-induced portal hypertension and liver lesions in rats, measured by direct portal vein pressure and histological assessment.
Prkacin, I; Separovic, J; Aralicia, G; Perovic, D; Gjurasin, M; Lovric-Bencic, M; Stancic-Rokotov, D; Staresinic, M; Anic, T; Mikus, D; Sikiric, P; Seiwerth, S; Mise, S; Rotkvic, I; Jagic, V; Rucman, R; Petek, M; Turkovic, B; Marovic, A; Sebecic, B; Boban-Blagaic, A; Kokic, N · Animal Study
BPC-157 at 10 μg/kg and 10 ng/kg IP produced anxiolytic effects comparable to diazepam in both the shock probe/burying test (reduced defensive burying) and light/dark test (increased light exploration) in rats.
Sikiric, P; Jelovac, N; Jelovac-Gjeldum, A; Dodig, G; Staresinic, M; Anic, T; Zoricic, I; Ferovic, D; Aralica, G; Buljat, G; Prkacin, I; Lovric-Bencic, M; Separovic, J; Seiwerth, S; Rucman, R; Petek, M; Turkovic, B; Ziger, T · Animal Study
BPC-157 attenuated cysteamine-induced colon and duodenal lesions, including in gastrectomized rats, demonstrating acid-independent healing and extending its protective effects to the entire gut.
Sikiric, P; Seiwerth, S; Grabarevic, Z; Balen, I; Aralica, G; Gjurasin, M; Komericki, L; Perovic, D; Ziger, T; Anic, T; Prkacin, I; Separovic, J; Stancic-Rokotov, D; Lovric-Bencic, M; Mikus, D; Staresinic, M; Aralica, J; DiBiaggio, N; Simec, Z; Turkovic, B; Rotkvic, I; Mise, S; Rucman, R; Petek, M; Sebecic, B; Ivasovic, Z; Boban-Blagaic, A; Sjekavica, I · Animal Study
BPC-157 attenuated both intratracheal HCl-induced lung lesions and associated gastric damage in rats, demonstrating cytoprotective effects extending beyond the GI tract to the respiratory system.
Stancic-Rokotov, D; Slobodnjak, Z; Aralica, J; Aralica, G; Perovic, D; Staresinic, M; Gjurasin, M; Anic, T; Zoricic, I; Buljat, G; Prkacin, I; Sikiric, P; Seiwerth, S; Rucman, R; Petek, M; Turkovic, B; Kokic, N; Jagic, V; Boban-Blagaic, A · Animal Study
BPC-157 attenuated chronic amphetamine-induced tolerance, behavioral sensitization, and withdrawal disturbances in rats, demonstrating comprehensive dopamine system stabilization against stimulant drug-induced neuroplasticity.
Sikiric, Predrag; Jelovac, Nikola; Jelovac-Gjeldum, Andjelka; Dodig, Goran; Staresinic, Mario; Anic, Tomislav; Zoricic, Ivan; Rak, Davor; Perovic, Darko; Aralica, Gorana; Buljat, Gojko; Prkacin, Ingrid; Lovric-Bencic, Martina; Separovic, Jadranka; Seiwerth, Sven; Rucman, Rudolf; Petek, Marijan; Turkovic, Branko; Ziger, Tihomil; Boban-Blagaic, Alenka; Bedekovic, Vlado; Tonkic, Ante; Babic, Slaven · Animal Study
BPC-157 maintained duodenal ulcer healing after sialoadenectomy while cimetidine and ranitidine lost effectiveness, demonstrating BPC-157's independence from salivary gland-derived protective factors — a unique pharmacological property.
Bedekovic, Vlado; Mise, Stjepan; Anic, Tomislav; Staresinic, Mario; Gjurasin, Miroslav; Kopljar, Mario; Kalogjera, Livije; Drvis, Petar; Boban Blagaic, Alenka; Batelja, Lovorka; Seiwerth, Sven; Sikiric, Predrag · Animal Study
Topical BPC-157 cream reversed methylprednisolone-induced burn wound healing impairment in mice, restoring wound closure rates during concurrent steroid treatment.
Sikiric, P; Seiwerth, S; Mise, S; Staresinic, M; Bedekovic, V; Zarkovic, N; Borovic, S; Gjurasin, M; Boban-Blagaic, A; Batelja, L; Rucman, R; Anic, T · Animal Study
BPC-157 accelerated transected Achilles tendon healing in rats (improved biomechanics and histology) and directly stimulated tendocyte proliferation in vitro, demonstrating both functional repair and cellular mechanism.
Staresinic, M; Sebecic, B; Patrlj, L; Jadrijevic, S; Suknaic, S; Perovic, D; Aralica, G; Zarkovic, N; Borovic, S; Srdjak, M; Hajdarevic, K; Kopljar, M; Batelja, L; Boban-Blagaic, A; Turcic, I; Anic, T; Seiwerth, S; Sikiric, P · Animal Study
BPC-157 protected against acute ethanol toxicity (reduced mortality, behavioral impairment, gastric damage) and chronic alcohol effects (reduced intake, liver protection), demonstrating comprehensive anti-alcohol therapeutic potential.
Blagaic, Alenka Boban; Blagaic, Vladimir; Romic, Zeljko; Sikiric, Predrag · Animal Study
BPC-157 reversed doxorubicin-induced CHF signs and normalized elevated Big Endothelin-1 levels in rats, comparable to amlodipine and losartan — demonstrating cardioprotective peptide activity against chemotherapy-induced cardiomyopathy.
Lovric-Bencic, Martina; Sikiric, Predrag; Hanzevacki, Jadranka S; Seiwerth, Sven; Rogic, Dunja; Kusec, Vesna; Aralica, Gorana; Konjevoda, Pasko; Batelja, Lovorka; Blagaic, Alenka B · Animal Study
BPC-157 produced region-specific changes in brain serotonin synthesis measured by alpha-methyl-L-tryptophan autoradiography — increasing synthesis in some regions while decreasing it in others, providing the serotonergic basis for its mood-modulating properties.
Tohyama, Y; Sikirić, P; Diksic, M · Animal Study
BPC-157 healed gastric ulcers in multiple rat models through comprehensive mechanisms: promoted angiogenesis, reduced inflammation, enhanced cytoprotection, and accelerated mucosal regeneration — acting through pathways independent of acid secretion reduction.
Xue, Xiao-Chang; Wu, Yong-Jie; Gao, Ming-Tang; Li, Wen-Guang; Zhao, Ning; Wang, Zeng-Lu; Bao, Chun-Jie; Yan, Zhen; Zhang, Ying-Qi · Animal Study
Local BPC-157 application accelerated CO2 laser wound healing in mice with faster re-epithelialization and wound contraction, extending BPC-157's documented wound healing to laser-induced tissue damage relevant to surgical and cosmetic dermatology.
Bilic, M; Bumber, Z; Blagaic, A Boban; Batelja, L; Seiwerth, S; Sikiric, P · Animal Study
BPC-157 effectively counteracted serotonin syndrome signs (hyperthermia, tremor, rigidity, agitation) induced by multiple serotonergic drugs in rats, demonstrating serotonergic system modulation complementing its known dopaminergic and GABAergic interactions.
Boban Blagaic, Alenka; Blagaic, Vladimir; Mirt, Mirela; Jelovac, Nikola; Dodig, Goran; Rucman, Rudolf; Petek, Marijan; Turkovic, Branko; Anic, Tomislav; Dubovecak, Miroslav; Staresinic, Mario; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 accelerated corneal epithelial defect healing in rats with faster re-epithelialization compared to controls, extending its documented tissue repair capabilities to the eye — a new organ system for BPC-157 therapeutic application.
Lazić, Ratimir; Gabrić, Nikica; Dekaris, Iva; Bosnar, Damir; Boban-Blagaić, Alenka; Sikirić, Predrag · Animal Study
BPC-157's protective effects against acute ethanol toxicity and chronic alcohol consumption were modulated by NO synthase inhibitor L-NAME, implicating the nitric oxide system as a mediating pathway in BPC-157's anti-alcohol therapeutic mechanism.
Boban-Blagaic, Alenka; Blagaic, Vladimir; Romic, Zeljko; Jelovac, Nikola; Dodig, Goran; Rucman, Rudolf; Petek, Marijan; Turkovic, Branko; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 promoted tendon-to-bone healing at the Achilles detachment site in rats, improving both normal healing AND opposing corticosteroid-impaired healing — demonstrating efficacy in the clinically challenging scenario of tendon repair during steroid therapy.
Krivic, Andrija; Anic, Tomislav; Seiwerth, Sven; Huljev, Dubravko; Sikiric, Predrag · Animal Study
BPC-157 healed prolonged esophagitis and improved lower esophageal sphincter function in a rat reflux model with sphincter failure, addressing both mucosal damage AND the mechanical cause (sphincter dysfunction) of reflux disease.
Petrovic, Igor; Dobric, Ivan; Drvis, Petar; Shejbal, Drazen; Brcic, Luka; Blagaic, Alenka Boban; Batelja, Lovorka; Kokic, Neven; Tonkic, Ante; Mise, Stjepan; Baotic, Tomislav; Staresinic, Mario; Radic, Bozo; Jakir, Ana; Vuksic, Tihomir; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 (Pliva clinical trial designations: PL-10, PLD-116, PL 14736) for IBD is supported by extensive animal data: heals colitis/esophagitis/gastric lesions, provides cytoprotection, reduces inflammation through NO and prostaglandin pathways, and maintains gut integrity across multiple models.
Sikiric, P; Seiwerth, S; Brcic, L; Blagaic, A B; Zoricic, I; Sever, M; Klicek, R; Radic, B; Keller, N; Sipos, K; Jakir, A; Udovicic, M; Tonkic, A; Kokic, N; Turkovic, B; Mise, S; Anic, T · Animal Study
BPC-157 accelerated healing of transected quadriceps muscle in rats with improved functional recovery and histological organization compared to controls, demonstrating efficacy for major skeletal muscle injury repair beyond tendon healing.
Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka; Boban-Blagaic, Alenka; Zoric, Zdenka; Ivanovic, Domagoj; Ajduk, Marko; Sebecic, Bozidar; Patrlj, Leonardo; Sosa, Tomislav; Buljat, Gojko; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 healed prolonged esophagitis caused by primary pyloric sphincter dysfunction in rats, improving mucosal integrity and sphincter function — demonstrating efficacy in a reflux model where the underlying cause is sphincter failure.
Dobric, Ivan; Drvis, Petar; Petrovic, Igor; Shejbal, Drazen; Brcic, Luka; Blagaic, Alenka Boban; Batelja, Lovorka; Sever, Marko; Kokic, Neven; Tonkic, Ante; Zoricic, Ivan; Mise, Sandro; Staresinic, Mario; Radic, Bozo; Jakir, Ana; Babel, Jaksa; Ilic, Spomenko; Vuksic, Tihomir; Jelic, Ivan; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 in IBD clinical trials supported by expanded animal evidence: heals colitis/fistulas/strictures, modulates NO and prostaglandin systems, promotes angiogenesis, and shows cytoprotection across multiple GI inflammation models — updated pre-clinical support for advancing clinical development.
Vuksic, Tihomir; Zoricic, Ivan; Brcic, Luka; Sever, Marko; Klicek, Robert; Radic, Bozo; Cesarec, Vedran; Berkopic, Lidija; Keller, Neike; Blagaic, Alenka Boban; Kokic, Neven; Jelic, Ivan; Geber, Juraj; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag · Animal Study
BPC-157 (PL14736, in IBD clinical trials) effectively healed various types of healing-impaired wounds in rats including steroid-impaired, denervated, and complex soft tissue injuries — expanding its clinical development potential from IBD to wound healing indications.
Klicek, Robert; Sever, Marko; Radic, Bozo; Drmic, Domagoj; Kocman, Ivan; Zoricic, Ivan; Vuksic, Tihomir; Ivica, Mihovil; Barisic, Ivan; Ilic, Spomenko; Berkopic, Lidija; Vrcic, Hrvoje; Brcic, Luka; Blagaic, Alenka Boban; Coric, Marijana; Brcic, Iva; Rokotov, Dinko Stancic; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag · Animal Study