BPC-157 healed prolonged esophagitis resulting from pyloric sphincter dysfunction in rats, improving both esophageal mucosal healing and sphincter function — addressing the root cause of this reflux model.
Key findingBPC-157 healed prolonged esophagitis caused by primary pyloric sphincter dysfunction in rats, improving mucosal integrity and sphincter function — dem
What the researchers found
BPC-157 healed prolonged esophagitis caused by primary pyloric sphincter dysfunction in rats, improving mucosal integrity and sphincter function — demonstrating efficacy in a reflux model where the underlying cause is sphincter failure.
Why it matters
Relevant for bpc-157, gut-healing.
How the study worked
animal-study study on bpc-157, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157.
Journal of pharmacological sciences, 104(1), 7-18
Citation
Dobric, Ivan; Drvis, Petar; Petrovic, Igor; Shejbal, Drazen; Brcic, Luka; Blagaic, Alenka Boban; Batelja, Lovorka; Sever, Marko; Kokic, Neven; Tonkic, Ante; Zoricic, Ivan; Mise, Sandro; Staresinic, Mario; Radic, Bozo; Jakir, Ana; Babel, Jaksa; Ilic, Spomenko; Vuksic, Tihomir; Jelic, Ivan; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag. (2007). Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157.. Journal of pharmacological sciences, 104(1), 7-18.