BPC-157's protection against acute and chronic ethanol effects in mice was modulated by nitric oxide system manipulation, revealing NO signaling as part of BPC-157's anti-alcohol therapeutic mechanism.
Key findingBPC-157's protective effects against acute ethanol toxicity and chronic alcohol consumption were modulated by NO synthase inhibitor L-NAME, implicatin
What the researchers found
BPC-157's protective effects against acute ethanol toxicity and chronic alcohol consumption were modulated by NO synthase inhibitor L-NAME, implicating the nitric oxide system as a mediating pathway in BPC-157's anti-alcohol therapeutic mechanism.
Why it matters
Relevant for bpc-157, addiction.
How the study worked
animal-study study on bpc-157, addiction.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.
Medical science monitor : international medical journal of experimental and clinical research, 12(1), BR36-45
Citation
Boban-Blagaic, Alenka; Blagaic, Vladimir; Romic, Zeljko; Jelovac, Nikola; Dodig, Goran; Rucman, Rudolf; Petek, Marijan; Turkovic, Branko; Seiwerth, Sven; Sikiric, Predrag. (2006). The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.. Medical science monitor : international medical journal of experimental and clinical research, 12(1), BR36-45.