Browse more peptide research, methods and limitations.
Comparative analysis of pioglitazone and tirzepatide on body weight and glucose shows tirzepatide superior for weight loss while both effectively lower blood sugar through different mechanisms.
Alhowail, Ahmad; Aldawsari, Mohammed F; Aldubayan, Maha · Animal Study
Study identifies barriers to GLP-1 agonist use for obesity management among patients, including cost, insurance denial, side effects, and prescriber hesitancy.
Alhowiti, Amirah; Mirghani, Hyder; Abdulrahman Qrmli, Abdulaziz; Albalawi, Amal Abdullah; Abdulrahman Aljohani, Raneem · Cohort
Analysis of GLP-1 agonist effects on HbA1c and insulin dose in type 1 diabetes patients shows potential insulin-sparing benefits alongside metabolic improvements.
Alhowiti, Amirah; Mirghani, Hyder · Meta Analysis
Systematic review confirms GLP-1 receptor agonists significantly reduce systolic blood pressure in diabetic patients, adding hypertension management to their benefit profile.
Ali, Abraish; Siddiqui, Asad Ali; Usman, Muhammad Shariq; Shahid, Izza; Khan, Muhammad Shahzeb; Perswani, Prinka · Meta Analysis
Liraglutide ameliorated methotrexate-induced cardiotoxicity in rats through anti-inflammatory and antioxidant pathway modulation, adding chemo-cardioprotection to GLP-1 benefits.
Ali, Dina A; Ibrahim, Dalia; Kolieb, Eman; Abdel Fattah, Islam O; Maher, Shymaa A; Elkelish, Amr; Abdalneim, Nasir A; Abozied, Nadia · Animal Study
Scoping review of GLP-1 agonist efficacy in psychiatric illnesses covers schizophrenia, depression, bipolar disorder, and addiction, finding emerging evidence for metabolic and possibly direct neuropsychiatric benefits.
Ali, Mohsan; Ahmed, Ayesha; Khan, Basim Ahmed; Shah, Syeda Taleha; Naveed, Sadiq; Ashraf, Nauman · Review
Medication adherence comparison between semaglutide and empagliflozin in T2D found differences in persistence and compliance, informing drug selection for treatment sustainability.
Ali, Mostafa A S; Amirthalingam, Palanisamy; Alshareef, Hanan; Alqifari, Saleh F; Elsaid Hamdan, Ahmed Mohsen; Alatawi, Olayan; Hakami, Faris Ahmed M; Albalawi, Nader Salem; Aljabri, Ahmed · Cohort
Analysis of Facebook mentions of GLP-1 drug adverse events captures patient-reported side effects not fully represented in clinical trials or formal reporting systems.
Alibilli, Amrutha S; Jain, Vidur; Mane, Heran; Yue, Xiaohe; Ratzki-Leewing, Alexandria; Merchant, Junaid S; Criss, Shaniece; Nguyen, Quynh C; McCoy, Rozalina G; Nguyen, Thu T · Cohort
Review of GLP-1 and GIP receptor agonists'expanding role covers their guideline-directed use across cardiovascular, kidney, and metabolic conditions with emerging evidence for dual agonism.
Alicic, Radica Z; Neumiller, Joshua J · Review
CREB1 and GLP1R were significantly upregulated in OA cartilage across multiple cohorts with zero heterogeneity (I² = 0%), while ADCY3 was downregulated, revealing a disrupted incretin-cAMP signaling axis.
Alizargar, Javad · Meta Analysis
Pam2Cys-modified cancer-testis antigen peptides demonstrated self-adjuvanting properties in vivo, representing a simplified peptide vaccine approach for cancer immunotherapy.
Aljohani, Salwa; Edmonds, Alex G; Castelletto, Valeria; Seitsonen, Jani; Hamley, Ian W; Symonds, Peter; Brentville, Victoria A; Durrant, Lindy G; Mitchell, Nicholas J · Animal Study
Review explores semaglutide's expanding therapeutic applications beyond diabetes and obesity, covering cardiovascular, neurological, hepatic, and renal benefits.
Alkhatib, Mesk; Almasri, Noor; Alshwayyat, Sakhr; Almahariq, Hebah; Hammadeh, Bara M; Taimeh, Zaid; Alkhatib, Lean; Alshwayat, Anas; A Saadeh, Nesreen; Al-Kurdi, Mohammed Al-Mahdi · Review
Review of GLP-1 drug pleiotropic effects in heart failure covers anti-inflammatory, cardioprotective, and metabolic mechanisms that benefit HF patients beyond glucose control.
Alkhouri, Naim; Charlton, Michael; Gray, Meagan; Noureddin, Mazen · Review
SGLT2 inhibitors and GLP-1 receptor agonists have strong, complementary evidence for cardiovascular and kidney protection in CKM syndrome and are now widely guideline-endorsed.
Allahwala, Momina A; Marathe, Chinmay S; Nelson, Adam J; Psaltis, Peter J; Marathe, Jessica A · Review
Study examines GLP-1 receptor agonist use and risk of neovascular age-related macular degeneration, providing important eye safety data for this widely used drug class.
Allan, Kevin C; Cohn, Erin F; Bala, Suraj; Kim, Sonia B; Kaelber, David C; Singh, Rishi P; Talcott, Katherine E; Mammo, Danny A; Rachitskaya, Aleksandra V · Cohort
Evidence-based translation project develops a standardized GLP-1 weight loss protocol incorporating prescribing, monitoring, lifestyle, and dose optimization guidelines.
Allred, Meghan · Cohort
In-depth analysis of liraglutide cardiovascular benefits in type 2 diabetes examines the mechanisms and evidence supporting cardiac protection through GLP-1 receptor activation.
Alluri, Amruth A; Mitra, Avishek; Marepalli, Aamuktha; Raj, Kshitij; Gandhi, Nayan; Prystupa, Yuliya; Seetharaman, Rajmohan · Review
Review of incretin-based therapy advancements covers dual/triple agonists, oral formulations, and combination strategies with discussion of challenges and future research directions.
Alluri, Amruth A; Guntupalli, Yashaswi; Suvarna, Shruti Suresh; Prystupa, Yuliya; Khetan, Shrishti Prakash; Vejandla, Bharath; Babu Swathi, Naraginti Lenin · Review
Novel conjugate combining an ultrashort antimicrobial peptide with levofloxacin showed enhanced antibacterial activity against resistant strains through dual-mechanism killing.
Almaaytah, Ammar; Alrashdan, Aseel; Sabi, Salsabeel H · In Vitro
Albumin-binding approach mitigated fowlicidin-1 toxicity while preserving antimicrobial efficacy, demonstrating a strategy for making natural antimicrobial peptides safer for therapeutic use.
Almaaytah, Ammar; Bataineh, Bayan; Mhaidat, Nizar M; Sabi, Salsabeel · In Vitro
Review explores whether GLP-1 drugs can redefine transplantation standard of care by addressing post-transplant diabetes, obesity, and cardiovascular risk in organ recipients.
Almalki, Bassem A · Review
Case report of acute kidney injury following accelerated tirzepatide dosing in a patient with multiple comorbidities highlights the importance of gradual dose titration.
Almansour, Abdulelah H · Case Series
Retrospective analysis of FDA FAERS data identifies real-world safety concerns with tirzepatide beyond clinical trial reporting, including GI events and hypoglycemia patterns.
Almansour, Hadi A; Thaibah, Hilal A; Alfarhan, Moaddey; Al-Qahtani, Saeed A; Khardali, Amani A; Alshammari, Thamir M · Cohort
Study examines how fasting impacts physical activity motivation and weight reduction in patients on GLP-1 drugs, with implications for optimizing lifestyle during treatment.
Almaqhawi, Abdullah; Alabdulqader, Razan Anwar; Alkhteeb, Nurah Abdullatef; Alomair, Fai Ibrahim; Alhassan, Sarra Riyadh; Alnajjar, Jawad S · Cohort
NPY mRNA expression in the aging inferior colliculus of rats reveals age-related changes in neuropeptide signaling that may contribute to age-related hearing processing decline.
Almassri, Laila S; Crane, Kristen M; Hergenrother, Sean R; Singh, Gurveer; Barach, Gillian L; Iafrate, Melina C; Harris, Joshua C; Tokar, Nick; Ohl, Andrew P; Young, Jesse W; Mellott, Jeffrey G · Animal Study
Study of acute GLP-1 analog infusion effects on glycemic and neurohormonal responses reveals the immediate physiological impact of GLP-1 receptor activation on multiple body systems.
Almby, Kristina E; Wiklund, Urban; Lundqvist, Martin H; Pereira, Maria J; Abrahamsson, Niclas · RCT
Review of snake venom-derived peptides as anticancer candidates covers their mechanisms of tumor killing, selectivity, and potential for pioneering new cancer therapeutics.
Almeida, José R; Pinos-Tamayo, Edgar A; Mendes, Bruno; Robles-Loaiza, Alberto A; Syahputra, Rony Abdi; Oliveira, Ana Gabriela Silva; Ribeiro, Rosy Iara Maciel de A · Review
Review of GLP-1 drug implications for perioperative management covers anesthesia considerations, gastric residual volumes, surgical outcomes, and medication management around procedures.
Almohammad, Asmaa A; Aldossari, Sara K; Sukumbaji, Ziyad A; Faden, Raniah A; Almutairi, Mona A; Al-Harbi, Noura H; Al-Saaib, Majida Y; Almarshedy, Bandary S; Alharabi, Entesar A; Alhazri, Wafaa A; Altalhi, Abdulaziz M · Review
Retrospective study reveals GLP-1 analog therapy affects hemoglobin levels, identifying a previously underrecognized hematological effect of these widely used drugs.
Almuammar, Sarah A; Alzahrani, Hani K · Cohort
Novel deep learning model using self-attention mechanism improves cell-penetrating peptide prediction accuracy, accelerating peptide-based drug delivery development.
Almusallam, Naif; Shahid; Hayat, Maqsood; Alarfaj, Fawaz Khaled · In Vitro
Review of GLP-1/GIP drugs and bariatric surgery for obstructive sleep apnea shows both approaches improve OSA through weight loss, with drugs offering a non-surgical alternative.
Alnagar, Amr; Sinha, Yashashwi; Ahmad, Adil N; Ahmed, Awais; Noormohamed, Mohamed Saleem · Review
Novel nano-delivery system combining colchicine with peptide nanoparticles achieved targeted anti-inflammatory drug delivery with improved efficacy and reduced side effects.
Alnemeh-Al Ali, H; Bejaud, J; Lautram, N; Dupont, A; Eyer, J · In Vitro
Review of DPP-4 inhibitors explores novel therapeutic applications beyond diabetes, including cardiovascular protection, neurodegeneration, and inflammatory conditions.
Aloke, Chinyere; Adelusi, Oluwasola Abayomi; Onisuru, Olalekan Olugbenga; Iwuchukwu, Emmanuel Amarachi; Achilonu, Ikechukwu · Review
Tirzepatide was ineffective at mitigating doxorubicin-induced oxidative stress and cardiotoxicity, suggesting not all GLP-1/GIP drug protective effects extend to chemotherapy damage.
Alolayan, Salma A; Alhowail, Ahmad H · Animal Study
Analysis of dulaglutide efficacy and safety for weight reduction in diabetic patients confirms meaningful weight loss with acceptable tolerability profile.
Alonazi, Gadah K; Alawuad, Lamia A · Cohort
Review of GLP-1 agonist new perspectives in T2D covers updated glycemic and weight management evidence, emerging formulations, and expanded indications.
Alonso, Silvia Patricia; Valdes, Sergio; Doulatram-Gamgaram, Viyey Kishore · Review
Systematic review of molecular imaging in neuroendocrine tumor diagnosis covers somatostatin receptor-based PET/CT and SPECT, guiding diagnostic and treatment selection decisions.
Alonzo, Laura; Cannella, Roberto; Laudicella, Riccardo; Benfante, Viviana; Purpura, Pierpaolo; Micci, Giuseppe; Galia, Massimo; Brancatelli, Giuseppe; Midiri, Massimo; Alongi, Pierpaolo · Meta Analysis
Review of anti-obesity medication clinical studies in Arab countries shows growing GLP-1 drug evidence with region-specific efficacy and cultural/access considerations.
AlOtaibi, Haifa F; Al Taib, Hanan N; AlMuhaidib, Shadan; Alshagrawi, Saud; Almufarrih, Abdulmalik; Alalmai, Ola; Alnaserallah, Sahar; Alodah, Najla; Alqahtani, Saleh A; Alhazzani, Waleed · Review
Review of obesity pharmacotherapy advancements and challenges covers GLP-1/GIP drugs, emerging agents, access barriers, and the evolving treatment landscape.
Alotaibi, Saqer S; Eldrehmy, Essam H; Albogami, Sarah M; Alkhedaide, Adel; Dahab, Omima · Review
Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
Alpay, Berkay; Christensen, Rune Häckert; Al-Khazali, Haidar M; Ashina, Messoud; Ashina, Håkan · Review
Analysis compares semaglutide safety with bariatric surgery for weight management, evaluating whether the drug is a safer alternative for obese patients.
Alpert, Zoe; Katzman, Jonathan L; Lajam, Claudette M; Schwarzkopf, Ran; Rozell, Joshua C · Cohort
Review of how thermal challenge and food intake are mutually regulated through NPY and melanocortin neuropeptide pathways, revealing brain energy homeostasis mechanisms.
Alpár, Alán · Review
Review of non-surgical treatments for pancreatic neuroendocrine tumors covers somatostatin analogs, PRRT, and emerging therapies with efficacy and safety assessment.
AlQahtani, Mohammed Saad; Miutescu, Bogdan; Domilescu, Ielmina; Negru, Serban; Popovici, Dorel; Gadour, Eyad · Meta Analysis
Study comparing inflammatory biomarker responses between GLP-1 drugs and other diabetes treatments found GLP-1 RA produced superior anti-inflammatory effects.
Alrasheed, Tariq; Mostafa, Mohamed E A; Madkhali, Mohammed A; Khairy, Hesham A · Meta Analysis
Randomized open-label study evaluating different monitoring approaches for GLP-1 drug effectiveness found specific strategies that optimize treatment outcomes.
Alsaadi, Taoufik; Suliman, Reem; Yang, Jiyue; Agarwal, Ekta; Fullerton, Terence; Chou, Denise E; Whalen, Ed; El Jadam, Caline; Al Qaisi, Ibrahim; Amin, Youssef; Alkhateri, Athra; Alsaffarini, Kareem; Abraham, Lucy; Zunaed, Zahra; Ahmed, Haytham M; Fathy, Mohamed; Hegab, Mohamed; Vainstein, Nora · RCT
Novel approach combining CGRP monoclonal antibodies with gepant small molecules offers innovative migraine management strategy using both drug classes synergistically.
Alsaadi, Taoufik; Adel, Fatema; Alsaffarini, Kareem; El Jadam, Caline; Alkhateri, Athra; Pagdato, Beverly; Suliman, Reem · Cohort
First report of pulmonary embolism following tirzepatide use adds to pharmacovigilance data for this GLP-1/GIP dual agonist with a potential thromboembolic signal.
Alsararatee, Hasan H · Case Series
Review of GLP-1 agonist developments for gestational diabetes explores efficacy evidence, safety concerns, and the potential role of these drugs in pregnancy-related metabolic disease.
Alshehri, Fahad S · Review
Review of tirzepatide's dual GLP-1/GIP mechanism explores therapeutic prospects across diabetes, obesity, NASH, cardiovascular disease, and emerging indications.
Alshehri, Ghadah H; Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Fawzy, Mohamed N; Waheed, Huda Jaber; Papadakis, Marios; Alexiou, Athanasios; El-Saber Batiha, Gaber · Review
Review proposes tirzepatide as a novel therapeutic approach for Alzheimer's disease through dual GLP-1/GIP neuroprotective mechanisms targeting neuroinflammation and metabolic dysfunction.
Alshehri, Ghadah H; Al-Kuraishy, Hayder M; Waheed, Huda Jaber; Al-Gareeb, Ali I; Faheem, Safaa A; Alexiou, Athanasios; Papadakis, Marios; El-Saber Batiha, Gaber · Review