Liraglutide Protects the Heart From Methotrexate Chemotherapy Damage
Liraglutide ameliorated methotrexate-induced cardiotoxicity in rats through anti-inflammatory and antioxidant pathway modulation, adding chemo-cardioprotection to GLP-1 benefits.
Quick Facts
What This Study Found
Liraglutide ameliorated methotrexate-induced cardiotoxicity in rats through anti-inflammatory and antioxidant pathway modulation, adding chemo-cardioprotection to GLP-1 benefits.
Key Numbers
Four groups of rats tested. Methotrexate given as single dose of 20 mg/kg. Two different liraglutide doses evaluated for cardioprotection.
How They Did This
Study methodology detailed in the full publication.
Why This Research Matters
These findings have practical implications for the growing number of patients using peptide-based therapies.
The Bigger Picture
This study contributes to the expanding evidence for peptide therapeutics in clinical practice.
What This Study Doesn't Tell Us
Study limitations in the full publication.
Questions This Raises
- ?What are the long-term implications?
- ?How do results compare to other evidence?
- ?What further research is needed?
Trust & Context
- Key Stat:
- Key finding Liraglutide ameliorated methotrexate-induced cardiotoxicity in rats through anti-inflammatory and an
- Evidence Grade:
- Evidence level based on study design in publication.
- Study Age:
- Published in 2025.
- Original Title:
- Liraglutide Ameliorates Methotrexate-Induced Cardiotoxicity in Rats: Modulation of Oxidative Stress, Autophagy, and the TNF-α/NF-κB Signaling Inflammatory Pathway.
- Published In:
- Journal of biochemical and molecular toxicology, 39(12), e70606 (2025)
- Authors:
- Ali, Dina A, Ibrahim, Dalia, Kolieb, Eman, Abdel Fattah, Islam O, Maher, Shymaa A, Elkelish, Amr, Abdalneim, Nasir A, Abozied, Nadia
- Database ID:
- RPEP-09863
Evidence Hierarchy
Frequently Asked Questions
What does this mean for patients?
Liraglutide ameliorated methotrexate-induced cardiotoxicity in rats through anti-inflammatory and antioxidant pathway modulation, adding chemo-cardioprotection to GLP-1 benefits.
How reliable is this?
Consult the full publication and healthcare provider.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-09863APA
Ali, Dina A; Ibrahim, Dalia; Kolieb, Eman; Abdel Fattah, Islam O; Maher, Shymaa A; Elkelish, Amr; Abdalneim, Nasir A; Abozied, Nadia. (2025). Liraglutide Ameliorates Methotrexate-Induced Cardiotoxicity in Rats: Modulation of Oxidative Stress, Autophagy, and the TNF-α/NF-κB Signaling Inflammatory Pathway.. Journal of biochemical and molecular toxicology, 39(12), e70606. https://doi.org/10.1002/jbt.70606
MLA
Ali, Dina A, et al. "Liraglutide Ameliorates Methotrexate-Induced Cardiotoxicity in Rats: Modulation of Oxidative Stress, Autophagy, and the TNF-α/NF-κB Signaling Inflammatory Pathway.." Journal of biochemical and molecular toxicology, 2025. https://doi.org/10.1002/jbt.70606
RethinkPeptides
RethinkPeptides Research Database. "Liraglutide Ameliorates Methotrexate-Induced Cardiotoxicity ..." RPEP-09863. Retrieved from https://rethinkpeptides.com/research/ali-2025-liraglutide-ameliorates-methotrexateinduced-cardiotoxicity
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.