Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
Key findingComprehensive review of substance P role in the trigeminovascular system covers preclinical mechanis
What the researchers found
Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
Why it matters
Relevant to peptide-based therapeutic applications.
The numbers in context
Review covers substance P synthesis, NK-1 receptor signaling, and clinical trial history for NK-1 antagonists in migraine.
How the study worked
Methodology in publication.
Who was studied
Review covering preclinical and clinical migraine research involving substance P
What this study cannot tell us
Limitations in publication.
How to read the evidence
Based on study design.
When this study was published
Published in 2025.
The bigger picture
Contributes to peptide therapeutic evidence.
Questions still open
- Long-term implications?
- Comparison to evidence?
- Next research?
Common questions
What does this mean?
How reliable?
Read the original research
Substance P and the trigeminovascular system: From preclinical mechanisms to human headache induction.
Cephalalgia : an international journal of headache, 45(8), 3331024251355944
Citation
Alpay, Berkay; Christensen, Rune Häckert; Al-Khazali, Haidar M; Ashina, Messoud; Ashina, Håkan. (2025). Substance P and the trigeminovascular system: From preclinical mechanisms to human headache induction.. Cephalalgia : an international journal of headache, 45(8), 3331024251355944. https://doi.org/10.1177/03331024251355944