Substance P and the Trigeminovascular System: From Lab to Migraine Clinic
Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
Quick Facts
What This Study Found
Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
Key Numbers
Review covers substance P synthesis, NK-1 receptor signaling, and clinical trial history for NK-1 antagonists in migraine.
How They Did This
Methodology in publication.
Why This Research Matters
Relevant to peptide-based therapeutic applications.
The Bigger Picture
Contributes to peptide therapeutic evidence.
What This Study Doesn't Tell Us
Limitations in publication.
Questions This Raises
- ?Long-term implications?
- ?Comparison to evidence?
- ?Next research?
Trust & Context
- Key Stat:
- Key finding Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanis
- Evidence Grade:
- Based on study design.
- Study Age:
- Published in 2025.
- Original Title:
- Substance P and the trigeminovascular system: From preclinical mechanisms to human headache induction.
- Published In:
- Cephalalgia : an international journal of headache, 45(8), 3331024251355944 (2025)
- Authors:
- Alpay, Berkay, Christensen, Rune Häckert(2), Al-Khazali, Haidar M(3), Ashina, Messoud, Ashina, Håkan
- Database ID:
- RPEP-09898
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What does this mean?
Comprehensive review of substance P role in the trigeminovascular system covers preclinical mechanisms and clinical translation for migraine pathophysiology and treatment.
How reliable?
Consult publication and provider.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-09898APA
Alpay, Berkay; Christensen, Rune Häckert; Al-Khazali, Haidar M; Ashina, Messoud; Ashina, Håkan. (2025). Substance P and the trigeminovascular system: From preclinical mechanisms to human headache induction.. Cephalalgia : an international journal of headache, 45(8), 3331024251355944. https://doi.org/10.1177/03331024251355944
MLA
Alpay, Berkay, et al. "Substance P and the trigeminovascular system: From preclinical mechanisms to human headache induction.." Cephalalgia : an international journal of headache, 2025. https://doi.org/10.1177/03331024251355944
RethinkPeptides
RethinkPeptides Research Database. "Substance P and the trigeminovascular system: From preclinic..." RPEP-09898. Retrieved from https://rethinkpeptides.com/research/alpay-2025-substance-p-and-the
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.