Browse more peptide research, methods and limitations.
FAERS disproportionality analysis found signals of male sexual dysfunction (ED, decreased libido, orgasmic dysfunction) associated with GLP-1 receptor agonists.
Pourabhari Langroudi, Ashkan; Chen, Abby L; Basran, Satvir; Sommer, Elijah R; Stinson, James; Cheng, Yu-Sheng; Del Giuduce, Francesco; Scott, Michael; Eisenberg, Michael L · Pharmacovigilance
Zavegepant 10 mg nasal spray provided sustained pain reduction and functional improvement over 48 hours versus placebo in acute migraine.
Powell, Lauren; O'Sullivan, Fiona; Jayasinghe, Pramoda; Rogula, Basia; Dai, Feng; Cirillo, Jessica; Sweeney, Samantha; Abraham, Lucy; Ailani, Jessica · Rct
SGLT2 inhibitors and GLP-1 receptor agonists show potential benefits in HFpEF management, alongside emerging AI-driven diagnostic and management tools.
Pozzi, Andrea; Spoladore, Roberto; Iorio, Annamaria; Corrado, Giovanni; D'Amario, Domenico · Narrative Review
Metabolic dysfunction drives cardiovascular-renal disease and deserves primary positioning in the syndrome nomenclature as Met-CVRD.
Pozzilli, Paolo; Messina, Maria Vittoria; Roden, Michael · Narrative Review
Unplanned acute care within 7 days of PRRT was characterized in frequency, and a comprehensive radioprotection SOP was developed for these situations.
Prabhu, Roshan S; Russek, Rachel; McBride, James E; Price, Karen B; Garland, Danielle N; Franklin, Elizabeth; McHaffie, Derek R; Ward, Matthew C; Rowland, Chelsea L; Huffstetler, Courtney E; Hicks, Amy S · Observational
A lipidated GLP-1 analog forms unique, stable nano-vesicles through self-assembly, revealing previously unknown behavior in GLP-1 drug chemistry.
Prada Brichtova, Eva; Gomes Dos Santos, Ana L; Jackson, Sophie E · Laboratory
Two jellyfish venom peptides competitively inhibit ACE with IC50 values of 5.68 µM (IGDEPRHQYL) and 23.81 µM (IVGRPLANG), confirmed by molecular dynamics.
Prakash, Ramachandran Loganathan Mohan; Ravi, Deva Asirvatham; Hwang, Du Hyeon; Kang, Changkeun; Kim, Euikyung · Laboratory
Both drug classes reduced HbA1c significantly over 24 weeks, with GLP-1 agonists showing a slight edge in glycemic control.
Prakash, Ved; Gupta, Sangeeta; Singh, Saumya; Rawat, Anurag; Deshpande, Amit Vasant; Podder, Amrit; Jani, Parth · Rct
Ultrashort peptide hydrogels with cationic/hydrophobic design principles show broad-spectrum antibacterial activity through membrane disruption.
Pramanik, Bapan; Mukherjee, Payel; Ahmed, Sahnawaz · Narrative Review
Retrospective comparison tracked MACE rates between SGLT2i and GLP-1 RA users over 24 months in 300 T2DM patients.
Prasad Vudathaneni, Vijaya Krishna; Nadella, Swetha Bharathi; Varaprasad Movva, Kalikrishna; Dulipala, Phanindra; Boyapati, Ramanarayana · Observational
Expert survey revealed significant variability and unmet needs in PRRT response assessment, with no consensus on standardized criteria.
Prasad, Vikas; Koumarianou, Anna; Denecke, Timm; Sundin, Anders; Deroose, Christophe M; Pavel, Marianne; Christ, Emanuel; Lamarca, Angela; Caplin, Martyn; Castaño, Justo P; Dromain, Clarisse; Falconi, Massimo; Grozinsky-Glasberg, Simona; Hofland, Johannes; Knigge, Ulrich Peter; Kos-Kudla, Beata; Krishna, Balkundi A; Reed, Nicholas Simon; Scarpa, Aldo; Srirajaskanthan, Rajaventhan; Toumpanakis, Christos; Kjaer, Andreas; Hicks, Rodney J; Ambrosini, Valentina · Consensus Statement
Both empagliflozin and semaglutide increased endothelial progenitor cells after 12 weeks in well-controlled T1D, suggesting enhanced vascular repair.
Preložnik Navodnik, Maja; Reberšek, Katarina; Klinar, Katarina; Janež, Andrej; Podgornik, Helena · Rct
Replica-exchange MD simulations with custom force fields accurately capture the experimentally observed conformational stabilization from peptide stapling.
Price, Joshua L · Computational
GLP-1 drugs are being used off-label for pre-conception weight management, but safety data for this specific context remains limited.
Price, Sarah A L; Nankervis, Alison · Narrative Review
Carillon device achieved 98.5% implantation success in 204 HF patients, with improved BNP, functional class, and mitral regurgitation at 3 months.
Priebe-Brämer, Holger; Jaly, Firas; Rahunathan, Nithusa; Luedde, Mark; Albert, Alexander; Witte, Klaus K; Hippe, Hans-Joerg · Observational
Intranasal oxytocin modulated social motor mirroring in context- and person-dependent ways in autistic and non-autistic men.
Prinsen, Jellina; Alaerts, Kaat · Rct
A novel RKAA-peptide linker creates a more stable CD79b-ADC than polatuzumab vedotin, potentially widening the therapeutic window.
Probst, Philipp; Attinger-Toller, Isabella; Bertrand, Romain; Stark, Ramona; Santimaria, Roger; Schlereth, Bernd; Grabulovski, Dragan; Spycher, Philipp René · Laboratory
Semaglutide showed a disproportionate reporting signal for NAION in FDA adverse event data, even after controlling for diabetes as a confounding indication.
Procacci, Angela; Poluzzi, Elisabetta; De Ponti, Fabrizio; Raschi, Emanuel · Pharmacovigilance
GLP-1 drug-induced weight loss plus high discontinuation rates create a risk for sarcopenic obesity in older adults through muscle loss and weight cycling.
Prokopidis, Konstantinos; Daly, Robin M; Suetta, Charlotte · Narrative Review
NPY gene SNP variants were associated with egg production traits including timing of first egg, egg weight, and total production in Thai chickens.
Promket, Doungnapa; Kammongkun, Jennarong; Insee, Jiranan; Kenchaiwong, Wootichai; Pengmeesri, Khanitta; Somchan, Thassawan; Boonkum, Wuttigrai · Observational
GIP receptor agonism blocks IL-1β-induced aversion via parabrachial CGRP neurons while preserving anorexia through a separate circuit.
Province, Haley S; Hayes, Nikolas W; Leong, Nathan A; Lorch, Carolyn M; Pekerman, Alexandra; Xia, Jessica L; Beutler, Lisa R · Animal Study
RCT tested whether specialist-GP video conferences improved prescribing of recommended diabetes medications including GLP-1 RAs and SGLT2 inhibitors.
Prætorius, Thim; Baymler Lundberg, Anne Sofie; Klausen Fredslund, Eskild; Blach Rossen, Niklas; Gregersen, Søren; Prior, Anders; Søndergaard, Esben; Tang Knudsen, Søren; Sandbæk, Annelli · Rct
GLP-1 RAs have evolved from diabetes drugs to multi-organ therapeutics with proven cardiovascular benefits and emerging heart failure and kidney disease applications.
Psaltis, James P; Marathe, Jessica A; Nguyen, Mau T; Le, Richard; Bursill, Christina A; Marathe, Chinmay S; Nelson, Adam J; Psaltis, Peter J · Narrative Review
HDM1002 was tolerable at doses up to 600 mg in healthy volunteers with predictable GLP-1 class side effects.
Pu, Junliang; Huang, Yurui; Wan, Lei; Zhu, Mingxue; Wei, Huili; Gao, Hong; Zhong, Liping; Tang, Chengyong; Xu, Junfang · Rct
Ghrelin activates GHSR1a to suppress insulin, induce resistance, and promote hepatic glucose output (worsening diabetes), while LEAP2 antagonizes these effects. Paradoxically, ghrelin also protects against diabetic complications via anti-inflammatory, antioxidant, and anti-apoptotic pathways.
Pu, Yueli; Yang, Jianmei; Li, Wei; Wen, Yi; Zheng, Chunmei; Li, Yonglin; Wu, Lijuan; Ming, Yao; Zhao, Changying; Chen, Chen · Narrative Review
Collagen peptides show multi-pathway benefits for metabolic syndrome including GLP-1 stimulation, DPP-IV inhibition, ACE inhibition, and AMPK activation.
Pueyo-Arias, Marián; López-Yoldi, Miguel; Navas-Carretero, Santiago; González-Navarro, Carlos J; Zulet, María de Los Ángeles; Milagro, Fermin I · Narrative Review
Functionalized SAP hydrogels with collagen-binding and mimetic motifs significantly enhanced chondrogenic differentiation of human MSCs.
Pulat, Günnur; Gökmen, Oğuzhan; Özcan, Şerife; Karaman, Ozan · Laboratory
41 bioactive peptides identified from ginger with 4 confirmed to have antioxidant, ACE-inhibitory, and antibacterial activity through in vitro and molecular docking.
Purohit, Kruttika; Pathak, Rachana; Hayes, Evan; Sunna, Anwar · Laboratory
New-onset atrial fibrillation requiring intensive care occurred in a patient with no prior cardiac history shortly after starting tirzepatide.
Purvez, Akhtar; Mirza, Mohd; Bashir, Mudhasir · Case Report
GLP-1 RAs and tirzepatide show promising efficacy and safety in adolescent and elderly obesity populations, though evidence is more limited than in middle-aged adults.
Pérez López, Gilberto · Narrative Review
Selenium supplementation in goat kids enhanced the antioxidant and ACE-inhibitory activity of enzymatic hydrolysates derived from their meat.
Pérez-Ramirez, Silvia C; Cruz-Monterrosa, Rosy; Diaz-Ramirez, Mayra; León-Espinosa, Erika B; Aguilar-Toalá, José E; Rosas-Espejel, Monzerrat; Ramirez-Bribiesca, J Efren · Animal Study
Once-weekly semaglutide 1.0 mg improved health status and reduced body weight in real-world patients with HFpEF, obesity, and type 2 diabetes versus controls.
Pérez-Velasco, Miguel A; Bernal-López, Maria-Rosa; Trenas, Alicia; Ricci, Michele; López-Carmona, María-Dolores; García de Lucas, María-Dolores; Gómez-Huelgas, Ricardo; Pérez-Belmonte, Luis M · Observational
Submaximal doses of semaglutide combined with lifestyle modifications improved metabolic markers and obesity-related inflammation biomarkers over 12 weeks.
Péč, Martin Jozef; Jurica, Jakub; Péčová, Monika; Nagy, Norbert; Focko, Boris; Miertová, Zuzana; Ferencová, Nikola; Ságová, Ivana; Tonhajzerová, Ingrid; Bolek, Tomáš; Galajda, Peter; Mokáň, Marián; Samoš, Matej · Observational
Lipidation position and lipid nature significantly influence GLP-1 analog solubility, oligomerization, and long-term physical stability.
Přáda Brichtová, Eva; Edu, Irina A; Li, Xinyang; Becher, Frederik; Gomes Dos Santos, Ana L; Jackson, Sophie E · Laboratory
ACP guidelines provide evidence-based ranking of migraine prevention drugs including CGRP-targeted therapies alongside traditional options.
Qaseem, Amir; Cooney, Thomas G; Etxeandia-Ikobaltzeta, Itziar; Wilt, Timothy J; Harrod, Curtis S; Tice, Jeffrey A; Crandall, Carolyn J; Hicks, Lauri A; Cross, J Thomas; Fitterman, Nick; Lewis, Johanna; Linsky, Amy M; Maroto, Michael; Miller, Matthew C; Obley, Adam J; Owens, Douglas K; Shekelle, Paul G; Shamliyan, Tatyana; Yost, Jennifer · Guideline
LSTM-generated peptides with GRU-predicted anti-inflammatory activity showed stable IL-23R binding in molecular dynamics simulations.
Qayyum, Naila; Seo, Hana; Khan, Noman; Manan, Abdul; Ramachandran, Rajath; Haseeb, Muhammad; Kim, Eunha; Choi, Sangdun · Computational
GLP-1/GIP drug prescriptions were associated with reduced opioid overdoses and alcohol intoxications in over 500,000 patients with substance use disorders.
Qeadan, Fares; McCunn, Ashlie; Tingey, Benjamin · Cohort
QXJYG reduced post-MI inflammation and improved cardiac function by modulating the MK2/TTP anti-inflammatory pathway.
Qi, Jianghan; Gao, Xiaoyao; Han, Ying; Yang, Meiling; Wei, Chenyi; Zhang, Ling; Chu, Jianfeng · Animal Study
Semaglutide reversed cognitive impairment and hippocampal damage in diabetic mice, with gut microbiota identified as a key mediating mechanism.
Qi, Liqin; Kang, Huimin; Zeng, Feihui; Zhan, Menglan; Huang, Cuihua; Huang, Qintao; Lin, Lijing; He, Guanlian; Liu, Xiaoying; Liu, Xiaohong; Liu, Libin · Animal Study
Cyclic iRGD peptide-engineered PROTAC nanoparticles achieved 67% PD-L1 degradation with enhanced tumor penetration via integrin/neuropilin-1 pathways.
Qi, Qianqian; Zhang, Zhanyu; Ji, Xiang; Wang, Dun · Laboratory
GABABR activation suppresses GLP-1 RA chronotropic effects and reduces post-MI arrhythmogenesis through cardiac sympathetic modulation.
Qi, Run; Jingjing, Zhang; Hongchang, Gu; Chenyu, Li; He, Hu; Juan, Li; Yuqin, Zhao; Xiaolin, Wu · Animal Study
AZD0186 activated GLP-1 receptors, stimulated insulin secretion, and reduced weight in preclinical models, with acceptable Phase 1 human safety.
Qi, Weier; Boca, Simina M; Boianelli, Alessandro; Fredberg, Monica; Lundqvist, Sara; Davies, Graeme; Field, Joss; Brighton, Cheryl A; Snijder, Arjan; Grundevik, Pernilla; Eckernäs, Daniel; Träff, Annika Maria; Polla, Magnus; Pettersen, Daniel; Omar, Sami; Hansen, Lars; Janzén, David; Melin, Johanna; van Zuydam, Natalie; Logue, Jennifer; Wallenius, Kristina · Rct
Mendelian randomization found a genetic association between GLP-1 receptor activation and reduced obstructive sleep apnea risk.
Qian, Bei-Bei; Huang, Yu-Jie; Yan, Cai-Feng; Feng, Shang-Yong; She, Dun-Min · Mendelian Randomization
Frog hepcidin QsHep combines membrane-disrupting antibacterial activity with macrophage activation for dual protection against E. miricola infection.
Qiao, Fen; Qian, Xin-Yi; Feng, Yi-Kai; Chen, Jie · Animal Study
QsCATH suppressed pro-inflammatory cytokines and NF-κB/TNF pathways in macrophages, confirmed by transcriptomics and molecular docking.
Qiao, Fen; Qian, Xin-Yi; Wu, Jia-Le; Wang, Zi-Xuan; Feng, Yi-Kai; Chen, Jie · Laboratory
Phosphorylated octapeptides combining a kinase site with a self-assembling motif form enzyme-responsive intrinsically disordered nanofibers.
Qiao, Yuchen; Zia, Ayisha; Shy, Adrianna; Wu, Grace; Chu, Matthew; Liu, Zhiyu; Wang, Fengbin; Xu, Bing · Laboratory
Ticagrelor was superior to clopidogrel for angina symptoms and inflammatory marker reduction in unstable angina patients.
Qin, Donghui; Ren, Yuanyuan; Zhang, Na; Yang, Xue; Chen, Zhuo; Zhao, Changliang · Rct
Amino acid-modified chitosan enhanced octreotide absorption across lung epithelium in an amino acid type-dependent manner in cells and rats.
Qin, Lu; Cui, Zhixiang; Zhang, Ziwei; Zhai, Qiyao; Wu, Yu; Guan, Jian; Xu, Enyu; Zhang, Xin; Mao, Shirui · Animal Study
Phoenixin acts as a feedforward appetite signal in goldfish — feeding increases PNX expression, which in turn stimulates additional food intake.
Qin, Xiangfeng; Ye, Cheng; Chan, Ying Wai; Wong, Anderson O L · Animal Study
Diabetes caused autonomic nerve fiber damage and altered CGRP, NPY, VIP, and neurotransmitter enzyme levels in mouse choroids.
Qin, Yuan-Jun; Zhang, Yong-Chao; Lin, Yunru; Hong, Yiyi; Sun, Xufang; Xu, Fan; Chen, Changzheng · Animal Study