Minimally Invasive Heart Valve Repair Device Works in 98.5% of Heart Failure Patients
The Carillon Mitral Contour System was successfully implanted in 98.5% of 204 heart failure patients, improving BNP levels, symptoms, and valve function.
Quick Facts
What This Study Found
Carillon device achieved 98.5% implantation success in 204 HF patients, with improved BNP, functional class, and mitral regurgitation at 3 months.
Key Numbers
N=204; age 83+/-6; 68% female; 72% HFrEF; 98.5% implant success; 94% NYHA improvement at 3 months; 91% MR reduction; 10.4% procedural complications.
How They Did This
Single-center retrospective study of 204 consecutive patients receiving Carillon device from 2021-2024.
Why This Research Matters
Many elderly heart failure patients are too frail for surgery — a minimally invasive 98.5% success rate option fills a critical treatment gap.
The Bigger Picture
Minimally invasive structural heart interventions are expanding options for elderly patients who were previously considered untreatable.
What This Study Doesn't Tell Us
Single-center retrospective study. Only 3-month follow-up. No control group.
Questions This Raises
- ?Do the benefits persist beyond 3 months?
- ?How does this compare to surgical mitral repair or MitraClip in similar patients?
Trust & Context
- Key Stat:
- 98.5% success Carillon device implantation in 204 consecutive heart failure patients with mitral regurgitation
- Evidence Grade:
- Single-center retrospective series — good real-world evidence for feasibility but lacks randomized comparison.
- Study Age:
- Published in 2025, reflecting growing experience with indirect mitral annuloplasty.
- Original Title:
- Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real-world, single-centre experience.
- Published In:
- ESC heart failure, 12(6), 4410-4418 (2025)
- Authors:
- Priebe-Brämer, Holger, Jaly, Firas, Rahunathan, Nithusa, Luedde, Mark, Albert, Alexander, Witte, Klaus K, Hippe, Hans-Joerg
- Database ID:
- RPEP-13111
Evidence Hierarchy
Watches what happens naturally without intervening.
What do these levels mean? →Frequently Asked Questions
What is the Carillon device?
A minimally invasive device that repairs a leaking mitral heart valve through a vein, without open-heart surgery — it works by reshaping the valve ring.
Is this procedure safe for elderly patients?
This study showed a 98.5% success rate in patients averaging 83 years old, with low complication rates.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13111APA
Priebe-Brämer, Holger; Jaly, Firas; Rahunathan, Nithusa; Luedde, Mark; Albert, Alexander; Witte, Klaus K; Hippe, Hans-Joerg. (2025). Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real-world, single-centre experience.. ESC heart failure, 12(6), 4410-4418. https://doi.org/10.1002/ehf2.70016
MLA
Priebe-Brämer, Holger, et al. "Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real-world, single-centre experience.." ESC heart failure, 2025. https://doi.org/10.1002/ehf2.70016
RethinkPeptides
RethinkPeptides Research Database. "Indirect mitral annuloplasty in patients with reduced or pre..." RPEP-13111. Retrieved from https://rethinkpeptides.com/research/priebe-bramer-2025-indirect-mitral-annuloplasty-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.