Gastric sensorimotor function and gut hormone profiles (ghrelin, CCK, PYY) differed progressively between normal weight, overweight, and obese individuals, revealing body weight-dependent gut-brain signaling changes.
Key findingGastric accommodation, sensitivity, emptying, and gut hormones (ghrelin, CCK, PYY) showed progressive changes from normal through overweight to obese,
What the researchers found
Gastric accommodation, sensitivity, emptying, and gut hormones (ghrelin, CCK, PYY) showed progressive changes from normal through overweight to obese, with disrupted fasting/postprandial hormone profiles providing the hormonal basis for weight-dependent appetite dysfunction.
Why it matters
Relevant for neuropeptides, weight-loss, gut-healing.
How the study worked
cross-sectional study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people.
Gastroenterology, 131(6), 1717-24
Citation
Vazquez Roque, Maria I; Camilleri, Michael; Stephens, Debra A; Jensen, Michael D; Burton, Duane D; Baxter, Kari L; Zinsmeister, Alan R. (2006). Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people.. Gastroenterology, 131(6), 1717-24.