Combined CCK and GLP-1 administration produced additive appetite suppression and slowed gastric emptying in humans, supporting multi-peptide combination therapy for obesity treatment.
Key findingCombined CCK and GLP-1 infusion produced additive effects on appetite suppression and antropyloroduodenal motility in healthy humans — supporting comb
What the researchers found
Combined CCK and GLP-1 infusion produced additive effects on appetite suppression and antropyloroduodenal motility in healthy humans — supporting combination gut peptide therapy for superior satiety and weight management.
Why it matters
Relevant for glp-1, neuropeptides, weight-loss, gut-healing, clinical-trials.
How the study worked
RCT study on glp-1, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with translational implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.
American journal of physiology. Regulatory, integrative and comparative physiology, 288(6), R1477-85
Citation
Brennan, Ixchel M; Feltrin, Kate L; Horowitz, Michael; Smout, Andre J P M; Meyer, James H; Wishart, Judith; Feinle-Bisset, Christine. (2005). Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.. American journal of physiology. Regulatory, integrative and comparative physiology, 288(6), R1477-85.