CCK and GLP-1 Together: Additive Appetite Suppression From Combining Two Gut Satiety Signals
Combined CCK and GLP-1 administration produced additive appetite suppression and slowed gastric emptying in humans, supporting multi-peptide combination therapy for obesity treatment.
Quick Facts
What This Study Found
Combined CCK and GLP-1 infusion produced additive effects on appetite suppression and antropyloroduodenal motility in healthy humans — supporting combination gut peptide therapy for superior satiety and weight management.
Key Numbers
How They Did This
RCT study on glp-1, neuropeptides.
Why This Research Matters
Relevant for glp-1, neuropeptides, weight-loss, gut-healing, clinical-trials.
The Bigger Picture
Advances peptide research with translational implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Combined CCK and GLP-1 infusion produced additive effects on appetite suppression and antropyloroduodenal motility in healthy humans — supporting comb
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.
- Published In:
- American journal of physiology. Regulatory, integrative and comparative physiology, 288(6), R1477-85 (2005)
- Authors:
- Brennan, Ixchel M, Feltrin, Kate L, Horowitz, Michael(9), Smout, Andre J P M, Meyer, James H, Wishart, Judith, Feinle-Bisset, Christine
- Database ID:
- RPEP-01015
Evidence Hierarchy
Frequently Asked Questions
What was studied?
CCK and GLP-1 Together: Additive Appetite Suppression From Combining Two Gut Satiety Signals
What was found?
Combined CCK and GLP-1 administration produced additive appetite suppression and slowed gastric emptying in humans, supporting multi-peptide combination therapy for obesity treatment.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01015APA
Brennan, Ixchel M; Feltrin, Kate L; Horowitz, Michael; Smout, Andre J P M; Meyer, James H; Wishart, Judith; Feinle-Bisset, Christine. (2005). Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.. American journal of physiology. Regulatory, integrative and comparative physiology, 288(6), R1477-85.
MLA
Brennan, Ixchel M, et al. "Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.." American journal of physiology. Regulatory, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Evaluation of interactions between CCK and GLP-1 in their ef..." RPEP-01015. Retrieved from https://rethinkpeptides.com/research/brennan-2005-evaluation-of-interactions-between
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.