CCK: The Body's Primary Short-Term Fullness Signal From the Gut
CCK is the best-characterized gastrointestinal satiety signal, released by intestinal fat and protein to reduce meal size through vagal afferents and brain CCK-A receptors — the gold standard for understanding gut-derived satiety.
Quick Facts
What This Study Found
CCK released by intestinal fat/protein is the primary short-term satiety signal, acting through vagal afferents and brain CCK-A receptors to reduce meal size — the best-characterized gut satiety peptide with therapeutic implications for obesity.
Key Numbers
How They Did This
review study on neuropeptides, gut-healing.
Why This Research Matters
Relevant for neuropeptides, gut-healing, weight-loss, receptor-signaling.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding CCK released by intestinal fat/protein is the primary short-term satiety signal, acting through vagal afferents and brain CCK-A receptors to reduce me
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Gastrointestinal satiety signals II. Cholecystokinin.
- Published In:
- American journal of physiology. Gastrointestinal and liver physiology, 286(2), G183-8 (2004)
- Authors:
- Moran, Timothy H(2), Kinzig, Kimberly P
- Database ID:
- RPEP-00950
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
CCK: The Body's Primary Short-Term Fullness Signal From the Gut
What was found?
CCK is the best-characterized gastrointestinal satiety signal, released by intestinal fat and protein to reduce meal size through vagal afferents and brain CCK-A receptors — the gold standard for understanding gut-derived satiety.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00950APA
Moran, Timothy H; Kinzig, Kimberly P. (2004). Gastrointestinal satiety signals II. Cholecystokinin.. American journal of physiology. Gastrointestinal and liver physiology, 286(2), G183-8.
MLA
Moran, Timothy H, et al. "Gastrointestinal satiety signals II. Cholecystokinin.." American journal of physiology. Gastrointestinal and liver physiology, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Gastrointestinal satiety signals II. Cholecystokinin." RPEP-00950. Retrieved from https://rethinkpeptides.com/research/moran-2004-gastrointestinal-satiety-signals-ii
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.