CCK is the best-characterized gastrointestinal satiety signal, released by intestinal fat and protein to reduce meal size through vagal afferents and brain CCK-A receptors — the gold standard for understanding gut-derived satiety.
Key findingCCK released by intestinal fat/protein is the primary short-term satiety signal, acting through vagal afferents and brain CCK-A receptors to reduce me
What the researchers found
CCK released by intestinal fat/protein is the primary short-term satiety signal, acting through vagal afferents and brain CCK-A receptors to reduce meal size — the best-characterized gut satiety peptide with therapeutic implications for obesity.
Why it matters
Relevant for neuropeptides, gut-healing, weight-loss, receptor-signaling.
How the study worked
review study on neuropeptides, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Gastrointestinal satiety signals II. Cholecystokinin.
American journal of physiology. Gastrointestinal and liver physiology, 286(2), G183-8
Citation
Moran, Timothy H; Kinzig, Kimberly P. (2004). Gastrointestinal satiety signals II. Cholecystokinin.. American journal of physiology. Gastrointestinal and liver physiology, 286(2), G183-8.