The brain-gut axis integrates peripheral satiety peptides (GLP-1, PYY, CCK, ghrelin) with central neuropeptide circuits (NPY, POMC, CRF) through vagal and hormonal pathways to control food intake as a unified system.
Key findingFood intake control operates through an integrated brain-gut axis where peripheral peptides (GLP-1, PYY, CCK, ghrelin, amylin) signal via vagal and ho
What the researchers found
Food intake control operates through an integrated brain-gut axis where peripheral peptides (GLP-1, PYY, CCK, ghrelin, amylin) signal via vagal and hormonal routes to central circuits (NPY/AgRP, POMC/CART, CRF) for coordinated appetite regulation.
Why it matters
Advances understanding of glp-1, ghrp, neuropeptides, gut-healing, weight-loss.
How the study worked
review study examining glp-1 and ghrp.
What this study cannot tell us
Study-specific limitations; see abstract.
How to read the evidence
moderate evidence from review study.
When this study was published
Published in 2004.
The bigger picture
Contributes to peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation potential to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Brain-gut axis and its role in the control of food intake.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 55(1 Pt 2), 137-54
Citation
Konturek, S J; Konturek, J W; Pawlik, T; Brzozowski, T. (2004). Brain-gut axis and its role in the control of food intake.. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 55(1 Pt 2), 137-54.