The Brain-Gut Axis: How Gut Peptides and Brain Circuits Together Control How Much You Eat
The brain-gut axis integrates peripheral satiety peptides (GLP-1, PYY, CCK, ghrelin) with central neuropeptide circuits (NPY, POMC, CRF) through vagal and hormonal pathways to control food intake as a unified system.
Quick Facts
What This Study Found
Food intake control operates through an integrated brain-gut axis where peripheral peptides (GLP-1, PYY, CCK, ghrelin, amylin) signal via vagal and hormonal routes to central circuits (NPY/AgRP, POMC/CART, CRF) for coordinated appetite regulation.
Key Numbers
How They Did This
review study examining glp-1 and ghrp.
Why This Research Matters
Advances understanding of glp-1, ghrp, neuropeptides, gut-healing, weight-loss.
The Bigger Picture
Contributes to peptide research with clinical implications.
What This Study Doesn't Tell Us
Study-specific limitations; see abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation potential to evaluate.
Trust & Context
- Key Stat:
- Key finding Food intake control operates through an integrated brain-gut axis where peripheral peptides (GLP-1, PYY, CCK, ghrelin, amylin) signal via vagal and ho
- Evidence Grade:
- moderate evidence from review study.
- Study Age:
- Published in 2004.
- Original Title:
- Brain-gut axis and its role in the control of food intake.
- Published In:
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 55(1 Pt 2), 137-54 (2004)
- Authors:
- Konturek, S J, Konturek, J W, Pawlik, T, Brzozowski, T
- Database ID:
- RPEP-00935
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
The Brain-Gut Axis: How Gut Peptides and Brain Circuits Together Control How Much You Eat
What was found?
The brain-gut axis integrates peripheral satiety peptides (GLP-1, PYY, CCK, ghrelin) with central neuropeptide circuits (NPY, POMC, CRF) through vagal and hormonal pathways to control food intake as a unified system.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00935APA
Konturek, S J; Konturek, J W; Pawlik, T; Brzozowski, T. (2004). Brain-gut axis and its role in the control of food intake.. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 55(1 Pt 2), 137-54.
MLA
Konturek, S J, et al. "Brain-gut axis and its role in the control of food intake.." Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Brain-gut axis and its role in the control of food intake." RPEP-00935. Retrieved from https://rethinkpeptides.com/research/konturek-2004-braingut-axis-and-its
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.