Gut Peptides as Obesity Drugs: GLP-1, PYY, Ghrelin, and Others as Therapeutic Targets
Gut peptides including GLP-1, PYY, oxyntomodulin, and ghrelin are the most promising peripheral targets for obesity pharmacotherapy, with GLP-1 agonists leading clinical development.
Quick Facts
What This Study Found
Gut peptide-based obesity drugs including GLP-1 agonists, PYY analogs, oxyntomodulin, and ghrelin antagonists represent the most promising peripheral anti-obesity targets, with GLP-1 showing the most advanced clinical development.
Key Numbers
How They Did This
review study on glp-1, ghrp.
Why This Research Matters
Relevant for glp-1, ghrp, weight-loss, gut-healing.
The Bigger Picture
Advances peptide therapeutics research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Gut peptide-based obesity drugs including GLP-1 agonists, PYY analogs, oxyntomodulin, and ghrelin antagonists represent the most promising peripheral
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Gut peptides and other regulators in obesity.
- Published In:
- Seminars in liver disease, 24(4), 335-47 (2004)
- Authors:
- Scharf, Matthew T, Ahima, Rexford S
- Database ID:
- RPEP-00973
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Gut Peptides as Obesity Drugs: GLP-1, PYY, Ghrelin, and Others as Therapeutic Targets
What was found?
Gut peptides including GLP-1, PYY, oxyntomodulin, and ghrelin are the most promising peripheral targets for obesity pharmacotherapy, with GLP-1 agonists leading clinical development.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00973APA
Scharf, Matthew T; Ahima, Rexford S. (2004). Gut peptides and other regulators in obesity.. Seminars in liver disease, 24(4), 335-47.
MLA
Scharf, Matthew T, et al. "Gut peptides and other regulators in obesity.." Seminars in liver disease, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Gut peptides and other regulators in obesity." RPEP-00973. Retrieved from https://rethinkpeptides.com/research/scharf-2004-gut-peptides-and-other
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.