RPEP-05104 · 2020mCRAMP levels were elevated in psoriatic mouse skin and plasma. Psoriatic plasma augmented platelet activation in healthy mouse platelets. The effect was partially mediated through Fpr2/3 (FPR2/ALX), as receptor inhibition or knockout significantly reduced platelet activation.
Salamah, Maryam F; Vallance, Thomas M; Kodji, Xenia; Ravishankar, Divyashree; Williams, Harry F; Brain, Susan D; Vaiyapuri, Sakthivel · Animal Study
RPEP-05105 · 2020GHS-R1a protein was decreased in brain areas and kidneys of hypertensive rats. Ghrelin reduced arterial pressure and increased renal artery conductance in SHR. GHS-R1a antagonism altered renal electrolyte handling in normal but not hypertensive rats, suggesting impaired receptor function in hypertension.
Sales da Silva, Elder; Ferreira, Patrícia Maria; Castro, Carlos Henrique; Pacheco, Lilian Fernanda; Graziani, Daniel; Pontes, Carolina Nobre Ribeiro; Bessa, Amanda de Sá Martins de; Fernandes, Erika; Naves, Lara Marques; Ribeiro, Larissa Cristina Dos Santos; Mendonça, Michelle Mendanha; Gomes, Rodrigo Mello; Pedrino, Gustavo Rodrigues; Ferreira, Reginaldo Nassar; Xavier, Carlos Henrique · Animal Study
RPEP-05106 · 2020Marine collagen and its derivatives (gelatin, peptides) show versatile bioactive properties including potential for tissue engineering, wound healing, dietary supplementation for weight management and glycemic control, with growing preclinical and clinical evidence.
Salvatore, Luca; Gallo, Nunzia; Natali, Maria Lucia; Campa, Lorena; Lunetti, Paola; Madaghiele, Marta; Blasi, Federica Stella; Corallo, Angelo; Capobianco, Loredana; Sannino, Alessandro · Review
RPEP-05108 · 2020Synthetic peptide libraries have generated bioactive compounds with potencies from sub-nanomolar to micromolar over 25 years, with recent computational and engineering advances enabling more targeted library designs including focused tripeptide collections against druggable cavities.
Sandomenico, Annamaria; Caporale, Andrea; Doti, Nunzianna; Cross, Simon; Cruciani, Gabriele; Chambery, Angela; De Falco, Sandro; Ruvo, Menotti · Review
RPEP-05109 · 2020The 30% CP diet optimized growth, while 42% CP decreased ghrelin and insulin expression, increased CCK and peptide YY expression, and reduced growth performance compared to moderate protein levels.
Santos, W M; Costa, L S; López-Olmeda, J F; Costa, N C S; Santos, F A C; Oliveira, C G; Guilherme, H O; Bahiense, R N; Luz, R K; Ribeiro, P A P · Animal Study
RPEP-05110 · 2020ePCWP changes during HD correlated strongly with body weight changes (r=0.814, p<0.05) and with ANP changes (r=0.523), but not with BNP changes (p=0.47), making ePCWP the most sensitive real-time fluid status marker.
Sato, Hidemaro; Kawasaki, Masanori; Tanaka, Ryuhei; Yoshizane, Takashi; Ono, Koji; Tadokoro, Mitsunobu; Yano, Yoko; Kondou, Takehito; Kariya, Tatsuya; Nagata, Kijun; Gotoh, Koshi; Sawada, Shigeki; Noda, Toshiyuki; Watanabe, Sachiro · Observational
RPEP-05111 · 2020Pro-Hyp is a low molecular weight growth-initiating factor that selectively triggers proliferation of p75NTR-positive (stem cell-like) fibroblasts on collagen gel but not p75NTR-negative fibroblasts. Oral collagen/gelatin delivers Pro-Hyp to tissues and accelerates wound healing in animals and humans.
Sato, Kenji; Asai, Tomoko T; Jimi, Shiro · Review
RPEP-05112 · 2020tCPP conjugation achieved up to 4-fold elevated internalization rates for three clinical antibodies while retaining target specificity. tCPP-Kadcyla showed 6-fold increased cytotoxicity. Favorable pharmacokinetics limited off-target accumulation.
Sauter, Max; Strieker, Matthias; Kleist, Christian; Wischnjow, Artjom; Daniel, Volker; Altmann, Annette; Haberkorn, Uwe; Mier, Walter · In Vitro
RPEP-05113 · 2020Pancreatic polypeptide (PP) plasma levels showed a moderate association with perceived anxiety specifically in obese men. NPY and PYY were not associated with anxiety, depressiveness, or perceived stress.
Schaper, Selina Johanna; Hofmann, Tobias; Wölk, Ellen; Weibert, Elena; Rose, Matthias; Stengel, Andreas · Observational
RPEP-05114 · 2020Non-linear trimeric peptide vaccines enhanced dendritic cell antigen presentation to CD8+ T cells both in vitro and in vivo, generating KLRG1+ effector T cells capable of recognizing and killing antigen-expressing target cells.
Schetters, Sjoerd T T; Li, R J Eveline; Kruijssen, Laura J W; Engels, Steef; Ambrosini, Martino; Garcia-Vallejo, Juan J; Kalay, Hakan; Unger, Wendy W J; van Kooyk, Yvette · Animal Study
RPEP-05115 · 2020A hydrogel microsphere delivery system with a self-cleaving β-eliminative linker enables sustained release of exenatide from a single subcutaneous injection, providing once-monthly dosing for feline diabetes treatment.
Schneider, E L; Reid, R; Parkes, D G; Lutz, T A; Ashley, G W; Santi, D V · Animal Study
RPEP-05116 · 2020CGRP/receptor-targeting monoclonal antibodies represent a paradigm shift from repurposed treatments to migraine-specific prevention, with strong clinical trial evidence supporting their efficacy and favorable safety profiles.
Schoenen, J; Manise, M; Nonis, R; Gérard, P; Timmermans, G · Review
RPEP-05117 · 2020Substance P and bradykinin neuropeptide reporter assays were successfully adapted from serum to capillary blood and dried blood card formats, expanding their utility for inflammation and pain research.
Schreiber, U; Engl, C; Bayer, M; König, S · Methods Paper
RPEP-05118 · 2020Validation data confirms bradykinin and substance P protease activity assays are reliable when using capillary blood and blood card samples, supporting the protocols described in the companion methods paper.
Schreiber, Ulrich; Bayer, Malte; König, Simone · Methods Paper
RPEP-05119 · 2020Human defensins play a critical role in skin defense against S. aureus but are countered by bacterial evasion mechanisms. Enhancing or supplementing defensin activity represents a potential novel approach to combat staph skin infections.
Scudiero, Olga; Brancaccio, Mariarita; Mennitti, Cristina; Laneri, Sonia; Lombardo, Barbara; De Biasi, Margherita G; De Gregorio, Eliana; Pagliuca, Chiara; Colicchio, Roberta; Salvatore, Paola; Pero, Raffaela · Review
RPEP-05120 · 2020CPP-methylene blue conjugates showed enhanced cellular uptake, lysosomal localization, and improved photodynamic therapy efficacy against cancer cells compared to unconjugated methylene blue.
Ser, Jinhui; Lee, Ji Yeon; Kim, Yong Ho; Cho, Hoonsung · In Vitro
RPEP-05121 · 2020Salivary proteome analysis revealed significant variations in thymosin beta-4, defensins, and other proteins between mastocytosis subtypes (cutaneous, systemic with/without skin lesions) and healthy controls.
Serrao, Simone; Firinu, Davide; Olianas, Alessandra; Deidda, Margherita; Contini, Cristina; Iavarone, Federica; Sanna, M Teresa; Boroumand, Mozhgan; Amado, Francisco; Castagnola, Massimo; Messana, Irene; Del Giacco, Stefano; Manconi, Barbara; Cabras, Tiziana · Observational
RPEP-05122 · 2020Co-delivery of peptide neoantigens with STING agonists via nanoparticles enhanced neoantigen-specific CD8+ T cell responses and improved cancer vaccine efficacy, leveraging the STING pathway's role in tumor immune surveillance.
Shae, Daniel; Baljon, Jessalyn J; Wehbe, Mohamed; Christov, Plamen P; Becker, Kyle W; Kumar, Amrendra; Suryadevara, Naveenchandra; Carson, Carcia S; Palmer, Christian R; Knight, Frances C; Joyce, Sebastian; Wilson, John T · Animal Study
RPEP-05123 · 2020Higher viscosity konjac glucomannan delayed gastric emptying, increased GLP-1 and PYY secretion, and enhanced subjective satiety compared to lower viscosity or control conditions.
Shang, Longchen; Wang, Yi; Ren, Yanyan; Ai, Tingyang; Zhou, Peiyuan; Hu, Ling; Wang, Ling; Li, Jing; Li, Bin · Randomized Controlled Trial
RPEP-05124 · 2020Ghrelin knockout mice showed impaired counterregulatory responses to insulin-induced hypoglycemia, demonstrating that acyl-ghrelin is permissive for normal blood sugar recovery during hypoglycemic episodes.
Shankar, Kripa; Gupta, Deepali; Mani, Bharath K; Findley, Brianna G; Lord, Caleb C; Osborne-Lawrence, Sherri; Metzger, Nathan P; Pietra, Claudio; Liu, Chen; Berglund, Eric D; Zigman, Jeffrey M · Animal Study
RPEP-05125 · 2020MHCnuggets deep neural network achieved improved prediction of MHC class I and II neoantigen binding, with better support for rare alleles and scalability to large datasets compared to existing tools.
Shao, Xiaoshan M; Bhattacharya, Rohit; Huang, Justin; Sivakumar, I K Ashok; Tokheim, Collin; Zheng, Lily; Hirsch, Dylan; Kaminow, Benjamin; Omdahl, Ashton; Bonsack, Maria; Riemer, Angelika B; Velculescu, Victor E; Anagnostou, Valsamo; Pagel, Kymberleigh A; Karchin, Rachel · Computational
RPEP-05126 · 2020MALDI-TOF-MS identified antimicrobial peptides including beta-defensins in dairy cow urine, with confirmed antimicrobial activity. This is the first such characterization using this technique in bovine urine.
Sharma, Ambika; Nigam, Rajesh; Kumar, Ashish; Singh, Simmi · In Vitro
RPEP-05129 · 2020Stick insects possess a unique AMP repertoire including ancestral innate immunity genes lost by later insect clades, revealed by immune challenge and transcriptomic analysis.
Shelomi, Matan; Jacobs, Chris; Vilcinskas, Andreas; Vogel, Heiko · Basic Science
RPEP-05130 · 2020NPY acts through multiple receptor subtypes (Y1-Y5) to regulate appetite, cardiovascular tone, respiratory function, GI motility, and endocrine systems, with therapeutic implications for multiple disease areas.
Shende, Pravin; Desai, Drashti · Review
RPEP-05131 · 2020Cathelicidin-DM from D. melanostictus demonstrated broad-spectrum antimicrobial activity via membrane disruption and wound-healing properties in both in vitro and in vivo models.
Shi, Yaoqiang; Li, Chao; Wang, Mei; Chen, Zijun; Luo, Ying; Xia, Xue-Shan; Song, Yuzhu; Sun, Yi; Zhang, A-Mei · Animal Study
RPEP-05132 · 2020ER stress-induced α-defensin misfolding in Paneth cells correlated with intestinal dysbiosis and ileitis in a Crohn's disease mouse model, supporting a causal link between defensin dysfunction and IBD pathophysiology.
Shimizu, Yu; Nakamura, Kiminori; Yoshii, Aki; Yokoi, Yuki; Kikuchi, Mani; Shinozaki, Ryuga; Nakamura, Shunta; Ohira, Shuya; Sugimoto, Rina; Ayabe, Tokiyoshi · Animal Study
RPEP-05133 · 2020NPY-knockout zebrafish exhibited anxiety-like behaviors with increased brain pomc and avp mRNA levels, demonstrating NPY's anxiolytic role is evolutionarily conserved across vertebrates.
Shiozaki, Kazuhiro; Kawabe, Momoko; Karasuyama, Kiwako; Kurachi, Takayoshi; Hayashi, Akito; Ataka, Koji; Iwai, Haruki; Takeno, Hinako; Hayasaka, Oki; Kotani, Tomonari; Komatsu, Masaharu; Inui, Akio · Animal Study
RPEP-05134 · 2020Rice bran-derived peptides demonstrate anti-hypertensive activity primarily through ACE inhibition, with evidence from both in vitro and animal studies.
Shobako, Naohisa; Ohinata, Kousaku · Review
RPEP-05135 · 2020Tβ4 promotes neurological recovery through neurovascular remodeling, CNS plasticity enhancement, and modulation of Toll-like receptor/NF-κB inflammatory signaling pathways, with microRNA-mediated regulation.
Shomali, Navid; Baradaran, Behzad; Deljavanghodrati, Mina; Akbari, Morteza; Hemmatzadeh, Maryam; Mohammadi, Hamed; Jang, Yue; Xu, Huaxi; Sandoghchian Shotorbani, Siamak · Review
RPEP-05136 · 2020CPP-functionalized PEG-PLA micelles improved paclitaxel bioavailability, cellular uptake, and anti-tumor efficacy while reducing side effects in animal cancer models.
Shuai, Qi; Cai, Yue; Zhao, Guangkuo; Sun, Xuanrong · Animal Study
RPEP-05137 · 2020BPC-157 consistently promoted fistula healing in rat models across multiple organ systems, with effects linked to its anti-ulcer, cytoprotective, and wound-healing properties as a native gastric peptide.
Sikiric, Predrag; Drmic, Domagoj; Sever, Marko; Klicek, Robert; Blagaic, Alenka B; Tvrdeic, Ante; Kralj, Tamara; Kovac, Katarina K; Vukojevic, Jaksa; Siroglavic, Marko; Gojkovic, Slaven; Krezic, Ivan; Pavlov, Katarina H; Rasic, Domagoj; Mirkovic, Ivan; Kokot, Antonio; Skrtic, Anita; Seiwerth, Sven · Review
RPEP-05138 · 2020BPC-157 demonstrates protective effects across multiple organ systems beyond the stomach, including endothelial protection, vessel recruitment around occlusions, and counteraction of cancer cachexia through modulation of FoxO3a, p-AKT, p-mTOR, and p-GSK-3β pathways.
Sikiric, Predrag; Hahm, Ki-Baik; Blagaic, Alenka Boban; Tvrdeic, Ante; Pavlov, Katarina Horvat; Petrovic, Andrea; Kokot, Antonio; Gojkovic, Slaven; Krezic, Ivan; Drmic, Domagoj; Rucman, Rudolf; Seiwerth, Sven · Review
RPEP-05139 · 2020The engineered peptide mast-MO showed dual antimicrobial and immunomodulatory activity — directly killing bacteria through membrane permeabilization while recruiting leukocytes and controlling inflammation in animal infection models.
Silva, Osmar N; Torres, Marcelo D T; Cao, Jicong; Alves, Elaine S F; Rodrigues, Leticia V; Resende, Jarbas M; Lião, Luciano M; Porto, William F; Fensterseifer, Isabel C M; Lu, Timothy K; Franco, Octavio L; de la Fuente-Nunez, Cesar · Animal Study
RPEP-05140 · 2020The automated platform successfully generates and ranks macrocyclic designs across molecular scales, from small molecules through peptides to PROTACs and proteins, using established chemical reactions and reagents.
Sindhikara, Dan; Wagner, Michael; Gkeka, Paraskevi; Güssregen, Stefan; Tiwari, Garima; Hessler, Gerhard; Yapici, Engin; Li, Ziyu; Evers, Andreas · Computational
RPEP-05141 · 2020The MRM LC-MS/MS assay quantifies total alpha-synuclein, species-specific contributions, combined alpha/beta-synuclein, and post-translational modification signatures in a single streamlined analysis with wide linear range.
Singh, Serena; Khayachi, Anouar; Milnerwood, Austen J; DeMarco, Mari L · Methods Paper
RPEP-05142 · 2020Rhesus theta defensin 1 (RTD-1) inhibits high-risk HPV infection through charge-driven capsid clustering that prevents virions from binding to cell surface receptor complexes.
Skeate, Joseph G; Segerink, Wouter H; Garcia, Mauricio D; Fernandez, Daniel J; Prins, Ruben; Lühen, Kim P; Voss, Féline O; Da Silva, Diane M; Kast, W Martin · In Vitro
RPEP-05143 · 2020The sea lamprey CCK-8 peptide is highly similar to mammalian CCK, with CCK neurons distributed across hypothalamus, midbrain, and brainstem regions, and showing the first documented GABA-CCK co-localization in a non-mammalian vertebrate.
Sobrido-Cameán, D; Yáñez-Guerra, L A; Robledo, D; López-Varela, E; Rodicio, M C; Elphick, M R; Anadón, R; Barreiro-Iglesias, Antón · Basic Science
RPEP-05144 · 2020The substance P-conjugated vector stearyl-CMSP showed significant transfection specificity for NK1R-expressing cells, with stearyl-CMSP/p53 complexes displaying higher antiproliferative activity against NK1R-positive cells versus NK1R-negative cells.
Song, Jingjing; Huang, Sujie; Ma, Panpan; Zhang, Bao; Jia, Bo; Zhang, Wei · In Vitro
RPEP-05145 · 2020Thymosin beta-4 increased tight junction protein expression, reduced the F-actin to G-actin ratio, and significantly improved vascular permeability dysfunction caused by PrP(106-126) in human brain endothelial cells.
Song, Kibbeum; Han, Hye-Ju; Kim, Sokho; Kwon, Jungkee · In Vitro
RPEP-05146 · 2020Insect protein hydrolysates showed strong antioxidant activity (up to 944.8 μmol Trolox equivalent/g by ORAC) and ACE inhibition (IC50 as low as 55.5 μg protein/mL), but no antimicrobial or antidiabetic activity.
Sousa, Pedro; Borges, Sandra; Pintado, Manuela · In Vitro
RPEP-05147 · 2020SOARS-B enrolled 290 participants across seven sites for a 24-week randomized trial of intranasal oxytocin in ASD, making it the best-powered study to date.
Spanos, Marina; Chandrasekhar, Tara; Kim, Soo-Jeong; Hamer, Robert M; King, Bryan H; McDougle, Christopher J; Sanders, Kevin B; Gregory, Simon G; Kolevzon, Alexander; Veenstra-VanderWeele, Jeremy; Sikich, Linmarie · Clinical Trial Design
RPEP-05148 · 2020Three CGRP-targeting monoclonal antibodies are FDA-approved for migraine prevention, reducing attack frequency through a targeted mechanism not available with older drugs.
Spindler, Brittany L; Ryan, Melody · Review
RPEP-05149 · 2020Manufacturing differences between originator and follow-on GLP-1 analogs produce distinct impurity profiles with potential immunogenicity implications, requiring clinical evaluation.
Staby, Arne; Steensgaard, Dorte Bjerre; Haselmann, Kim F; Marino, Jesper Søndergaard; Bartholdy, Christina; Videbæk, Nicoline; Schelde, Ole; Bosch-Traberg, Heidrun; Spang, Lotte Touborg; Asgreen, Désirée J · Analytical
RPEP-05150 · 2020Cervical gene delivery of HBD3 significantly reduced uterine bacterial bioluminescence and increased the number of live-born pups compared to controls in an ascending infection model.
Suff, Natalie; Karda, Rajvinder; Diaz, Juan Antinao; Ng, Joanne; Baruteau, Julien; Perocheau, Dany; Taylor, Peter W; Alber, Dagmar; Buckley, Suzanne M K; Bajaj-Elliott, Mona; Waddington, Simon N; Peebles, Donald · Animal Study
RPEP-05151 · 2020CP-PGs with tri-lysine sequences (DKCK12-K3 and DKCK12-K5) showed lower cytotoxicity and superior peptide delivery compared to the well-established R8 cell-penetrating peptide.
Sumito, Natsumi; Koeda, Shuhei; Umezawa, Naoki; Inoue, Yasumichi; Tsukiji, Shinya; Higuchi, Tsunehiko; Mizuno, Toshihisa · In Vitro
RPEP-05152 · 2020VIP regulates IL-10 expression in regulatory B cells, influencing the Th1/Th2 balance and potentially providing a new mechanism for treating ulcerative colitis.
Sun, Xiong; Huang, Yao; Zhang, Ya-Li; Qiao, Dan; Dai, Yan-Cheng · Review
RPEP-05153 · 2020Gepants and lasmiditan have significant drug interaction potential with CYP3A4 inhibitors, serotonergic drugs, and transporter inhibitors, while CGRP monoclonal antibodies have pharmacodynamic interactions related to immune modulation.
Szkutnik-Fiedler, Danuta · Review
RPEP-05154 · 2020Digested whey samples were the most potent CCK and GLP-1 stimulators. Digested goat whey produced the highest GLP-1 release (86.33 pg/mL). Fermented mixture whey produced the highest CCK release (80.78 pg/mL). Undigested whey showed weak hormone stimulation.
Sánchez-Moya, T; Planes-Muñoz, D; Frontela-Saseta, C; Ros-Berruezo, G; López-Nicolás, R · In Vitro
RPEP-05155 · 2020Choline-oleate ionic liquid increased transdermal antigen peptide delivery 28-fold and produced superior anti-tumor vaccination effects compared to traditional injection.
Tahara, Yoshiro; Morita, Kaho; Wakabayashi, Rie; Kamiya, Noriho; Goto, Masahiro · Animal Study
RPEP-05156 · 2020Venom-derived KV1.3 inhibitors show efficacy in animal models of multiple autoimmune diseases, and the ShK analog dalazatide has completed Phase 1 trials for psoriasis.
Tajti, Gabor; Wai, Dorothy C C; Panyi, Gyorgy; Norton, Raymond S · Review