Browse more peptide research, methods and limitations.
ANIA deep learning framework predicts AMP MIC values against S. aureus, E. coli, and P. aeruginosa using inception-attention architecture for accurate potency prediction.
Chiu, Yen-Peng; Yao, Lantian; Tang, Yun; Chung, Chia-Ru; Pang, Yuxuan; Chiang, Ying-Chih; Lee, Tzong-Yi ·
AuNP-AptHis-RW-BP100His conjugate demonstrated therapeutic efficacy against intracellular Brucella canis in both RAW 264.7 macrophages and infected mice.
Cho, Seong Eun; Huy, Tran Xuan Ngoc; Nguyen, Trang Thi; Aguilar, Ched Nicole Turbela; Salad, Said Abdi; Hong, Il-Hwa; Min, Won-Gi; Lee, Hu-Jang; Yeom, Ji-Hyun; Kim, Suk ·
Disc and subchondral bone degeneration correlated with persistent LBP in rats, with neuronal sensitization including CGRP upregulation as a mediating mechanism.
Cho, Yun-Ho; Choi, Cham; Kwon, Minji; Kwon, Jinju; Ok, Hogwang; Ryu, Dawon; Yang, Kyung-Sook; Kim, Junesun; Park, Eui Ho ·
Multiple nano-engineered delivery platforms can significantly improve the cellular uptake, tumor targeting, and anticancer efficacy of the KLA pro-apoptotic peptide while reducing off-target effects.
Cho, Yunmi; Kim, Ha Gyeong; Oh, Eun-Taex ·
A sensitive LC-MS/MS method was developed and validated for tirzepatide quantification in rat plasma using protein precipitation extraction and peptide C18 column chromatography.
Choi, Hae-In; Jeong, Hyeon-Cheol; Jeong, Jong-Woo; Lee, Jaeyoung; Kim, Da Hae; Ko, Kyong-Cheol; Chae, Yoon-Jee; Lee, Kyeong-Ryoon ·
Diverse MASH therapeutics including resmetirom and GLP-1 RAs converge on AMPK signaling, providing a unified mechanistic framework for understanding their therapeutic effects.
Choi, Seungchan; Jung, Jin-Seok; Seo, Yie-Sung; Song, Sungmin; Ham, Jeehye; Chung, Hannah; Ramadan, Yousef; Choi, Kangchan ·
Comparative effectiveness analysis of four anti-obesity medications in psychiatric patients revealed differences in weight loss, adverse events, and early discontinuation rates in this understudied population.
Choi, Won-Seok; Song, Min-Kyu; Seo, Mansuk; Woo, Young Sup; Bahk, Won-Myong ·
The nationwide cohort study assessed associations between periconceptional GLP-1 RA exposure and adverse pregnancy outcomes in women with pregestational T2DM compared to insulin users.
Chou, Yi-Chang; Weng, Shih-Han; Cheng, Feng-Shiang; Tseng, Chih-Hao; Hu, Hsiao-Yun; Liu, Chieh-Hsing ·
S. pneumoniae infection upregulates Toll2, Toll9, and defensin genes in Bombyx larvae, confirming conserved innate immune responses and validating this insect model for pneumococcal research.
Chowdhury, Farhan R; Hossain, M Ismail; Jepu, Tangerul A; Saleh, Nusrat U A; Zohora, Fatema T; Saleh, Tasmim A; Sarker, Mrinmoy; Numan, Al; Yousuf, Zainab; Uddin, M Aftab; Hossain, Muktadir S ·
Rimegepant 75 mg effectively treated acute vestibular migraine symptoms including vertigo, unsteadiness, nausea/vomiting, photo/phonophobia, and headache.
Chu, Heling; Pan, Jingwei; Huang, Chuyi ·
GLP-1RA dispensing increased in youth with T2D from 2020-2023, but significant disparities existed between Medicaid and commercially insured youth.
Chu, Patricia Y; Kelly, Andrea; Hennessy, Sean; Vajravelu, Mary Ellen; Huang, Jing; Amaral, Sandra ·
Cagrilintide combined with GLP-1 receptor agonists achieves synergistic weight loss exceeding 15%, positioning amylin analogs as key players in diabesity treatment.
Chung, Chae Won; Kim, Jaetaek ·
Peptide-finasteride nanocomplexes promoted hair regeneration comparable to 5% minoxidil in vivo, using approximately 40-fold less finasteride than the standard oral dose.
Chung, Won Young; Kim, Ji-Eun; Lee, Jae Yun; Kim, Suin; Jeong, Woo-Jin ·
Semaglutide as adjunct to AF catheter ablation reduced arrhythmia recurrence (HR 0.52, 95% CI 0.34–0.78) with freedom from recurrence of 80.2% vs. 65.2% at 18 months.
Ciconte, Giuseppe; Salerno, Raffaele; Fuga, Alessandro; Vuturo, Alessia; Boccellino, Antonio; Negro, Gabriele; Rondine, Roberto; Ballarotto, Marco; Ciaccio, Cristiano; Izzo, Antonio; Morciano, Davide Antonio; Garbelli, Arianna; Giannelli, Luigi; Maiolo, Vincenzo; Calovic, Zarko; Anastasia, Luigi; Pappone, Carlo ·
CGRP was expressed in 50% of acromegaly adenomas and 0% of nonfunctioning pituitary adenomas (p<0.001). CGRP-positive tumors showed trends toward higher chronic headache rates (40% vs 13%) and lower postoperative remission (60% vs 86.7%).
Cil, Sanem; Pekmezci, Aslihan; Karatay, Huseyin; Dogukan, Fatih Mert; Burhan, Sebnem; Cil, Mehmet Said; Akpinar, Ebubekir; Erkan, Buruc; Niyazoglu, Mutlu; Hatipoglu, Esra ·
Quadruple-conjugated carbon dot nanomodel showed potent glioma cytotoxicity at 50 nM with >40-fold selectivity over normal cells, establishing a modular platform for targeted brain cancer therapy.
Cilingir, Emel Kirbas; Hettiarachchi, Sajini D; Rathee, Parth; Zhou, Yiqun; Ferreira, Braulio Clb; Wang, Lukun; Joji, Annu; Gonzalez, Carlos M; Moreno Hollweg, Maria J; Shiri, Mehrdad; Wang, Kun; Prabhakar, Rajeev; Vanni, Steven; Leblanc, Roger M; Graham, Regina M ·
AMPs demonstrate effective disruption of cariogenic, periodontal, root canal, peri-implantitis, and Candida-associated oral biofilms with minimal resistance development.
Ciren, Deji; Xia, Xiaoyue; Zhu, Yuemeng; Hui, Sumin; Hong, Lihua ·
Combination SGLT2i + GLP-1 RA therapy reduced MACE by 44% (RR 0.56), cardiovascular mortality by 74% (RR 0.26), and kidney composite endpoint by 52% (RR 0.48) vs. monotherapy.
Colombijn, Julia M T; de Leijer, Jan F; Visseren, Frank L J; Verhaar, Marianne C; van Raalte, Daniël H; Sattar, Naveed; Vernooij, Robin W M; van Sloten, Thomas T ·
Both SGLT2i and GLP-1 RAs exert cardiovascular protection through multiple anti-inflammatory pathways including cytokine reduction, oxidative stress mitigation, immune modulation, and endothelial function improvement.
Comșa, Adina David; Comșa, Horațiu; Cismaru, Gabriel; Roșu, Radu; Pop, Dana ·
31 semaglutide metabolites identified across five species, with peptide backbone hydrolysis as the primary metabolic pathway and a diagnostic m/z 469 fragment enabling efficient screening.
Cong, Yawen; Tang, Chongzhuang; Li, Zhiqiang; Gao, Yang; Chen, Lijuan; Xu, Haibo; Diao, Xingxing ·
SDX-7320 significantly attenuated obesity-accelerated tumor growth in three syngeneic mouse models and outperformed tirzepatide for tumor inhibition despite causing less weight loss, indicating direct anti-tumor mechanisms.
Cornelius, Peter; Mayes, Benjamin A; Dannenberg, Andrew J; Dufour, Pierre J; Little, Sara; Guzior, Douglas V; Petersen, John S; Shanahan, James M; Carver, Bradley J ·
Human epidemiological data do not confirm the thyroid or pancreatic cancer risks seen in rodent models, and semaglutide's anti-inflammatory and cardioprotective properties may offer additional clinical value beyond metabolic control.
Correra, Adriana; Mauriello, Alfredo; Cetoretta, Valeria; Maratea, Anna Chiara; Riegler, Lucia; Di Sarno, Isabella; Giallauria, Francesco; Guerra, Federico; Russo, Vincenzo; D'Andrea, Antonello ·
Across 182 transplant recipients, tirzepatide reduced HbA1c by 0.6-1.4 percentage points and body weight by 5.5-6.9 kg while maintaining stable tacrolimus levels (Δ -0.2 to +0.2 ng/mL) with no rejection signals.
Corrêa, Lucas Maciel de Almeida; Mazur, Gabriel Rian; Santiago, Clara Belo Gamon; Dante, Letícia Esteves; de Marco, Patrícia Silva; Ferrés, Paola Beatriz Souza ·
GLP-1 receptor agonists were associated with 56-73% lower mortality across stroke types, 27-30% lower rebleeding rates, and 18-38% reduced incidence of new strokes at 1-2 year follow-up.
Costa, Matias; O'Leary, Sean; Price, Anthony M; Young, Christopher C; Srinivasan, Visish M; Kan, Peter ·
PEGylated MAO titanium surfaces with adsorbed MSI-78 peptide reduced MRSA colonization and killed ~80% of adherent bacteria while maintaining full cytocompatibility with bone-like cells and supporting osteogenic response.
Costa, Natália A; Monteiro, Cláudia; Grenho, Liliana; Ribeiro, Ana R; Leiro, Victoria; Fernandes, Maria H; Lisboa-Filho, Paulo N; Martins, M Cristina L ·
Tripeptide P8-1 (pEKW) from B. bilineatus venom increased miniature end-plate potential frequency at the neuromuscular junction, representing the first identified bioactive tripeptides with presynaptic effects in Viperidae venom.
Couceiro, Fernanda Y G M; Pacagnelli, Francis L; Torres-Bonilla, Kristian A; Hyslop, Stephen; Lomonte, Bruno; Drummond, Robert M; Pimenta, Daniel C; Borges, Rafael J; Floriano, Rafael S ·
523 venom-related transcripts identified, with the potassium toxin TpK8 showing high-affinity binding to the Kv1.3 channel selectivity filter through molecular docking analysis.
Covali-Pontes, Henrique Ranieri; Meneguelli, Brayhan; Carretone, Jéssica de Moraes; Ribeiro, Alynne Coelho; Santos, Angélica Camargo Dos; Carlos, Thais Fernanda; Chiaratti, Marcos Roberto; Ferro, Milene; Silva, Flávio Henrique; Rodrigues, Renata Dos Santos; Lucena, Malson Neilson ·
No significant differences in composite GI adverse events were found: semaglutide vs dulaglutide HR 0.96 (0.87-1.06), tirzepatide vs dulaglutide HR 0.96 (0.77-1.20), tirzepatide vs semaglutide HR 1.07 (0.90-1.26).
Crisafulli, Salvatore; Alkabbani, Wajd; Paik, Julie M; Bykov, Katsiaryna; Tavakkoli, Ali; Glynn, Robert J; Htoo, Phyo T; Yu, Elaine W; Trifirò, Gianluca; Wexler, Deborah J; Patorno, Elisabetta ·
Core-shell nanoparticles mimicking chylomicrons achieved 9.67% pharmacological bioavailability for oral exenatide, with 5.6-fold increased intestinal permeability and persistent hypoglycemic effects in type 2 diabetic rats.
Cui, Shuman; An, Yalin; Cui, Zhixiang; Liu, Shiyun; Li, Hongfang; Wen, Xiangce; Guan, Jian; Mao, Shirui; Yi, Han; Zhang, Xin ·
A cathelicidin-like antimicrobial peptide demonstrated effective activity against multidrug-resistant Acinetobacter baumannii, disrupting biofilm formation in wound infection models.
Cândido, Elizabete de Souza; Buccini, Danieli Fernanda; Miranda, Elizangela de Barros; Gonçalves, Regina Meneses; Brandão, Amanda Loren de Oliveira; Nieto-Marín, Valentina; Leal, Ana Paula Ferreira; Rezende, Samilla Beatriz; Cardoso, Marlon Henrique; Franco, Octavio Luiz ·
100% of evaluable participants (37/37) developed neoantigen-specific immune responses, with a mean peak of ~1,100 interferon-γ spot-forming cells per million PBMCs, and 85% maintained detectable immunity at one year.
D'Alise, Anna Morena; Willis, Jason; Duzagac, Fahriye; Hall, Michael J; Cruz-Correa, Marcia; Idos, Gregory E; Thirumurthi, Selvi; Ballester, Veroushka; Leoni, Guido; Garzia, Irene; Antonucci, Laura; De Marco, Lorenzo; Micarelli, Elisa; Deng, Nan; Seclì, Laura; Gogov, Sven; Dong, Wenli; Jack Lee, J; Bowen, Charles M; Vornik, Lana A; Garcia-Gonzalez, Araceli; Reyes-Uribe, Laura; Richmond, Ellen; Umar, Asad; Brown, Powel H; Sinha, Krishna M; Rodriguez, Luz Maria; Scarselli, Elisa; Vilar, Eduardo ·
At 1 and 2 years post-surgery, GLP-1 agonist users had significantly lower odds of pseudoarthrosis, hardware failures, wound dehiscence, infections, thromboembolic events, readmissions, and mortality after spinal deformity correction.
D'Amico, Cassandra; Jacques, Benjamin; Ferdon, Robert; Silvestre, Jason; Lewis, Stephen; Nielsen, Christopher; Glaser, John; Reitman, Charles; Lawrence, James; Ravinsky, Robert ·
PNAs demonstrate species-specific antimicrobial activity through targeted gene silencing, with recent delivery advances (cell-penetrating peptides, dendron conjugates, nanoparticles) significantly improving their therapeutic potential.
D'Aniello, Antonia; Masi, Annalisa; Avitabile, Concetta; Del Monaco, Giovanni; Saviano, Michele; Moccia, Maria ·
Adjuvant GLP-1RA improved antipsychotic adherence with 8.91% higher PDC (commercial) and 19.80% higher PDC (Medicaid), and 27.12 and 41.21 additional days of persistence, respectively.
Daggolu, Jerusha; Okonkwo, Michael; Chen, Hua ·
By January 2024, the female-to-male GLP-1RA utilization rate ratio reached 2.68 for adults (163.06 vs 60.84 per 10,000), with Wegovy showing the largest gap at 4.03:1 (57.86 vs 14.37 per 10,000).
Daggolu, Jerusha; Chen, Hua ·
Antimicrobial peptides from commensal skin bacteria interfere with the S. aureus Agr quorum-sensing system, inhibiting biofilm development and toxin production as a potential alternative to conventional antibiotics for chronic wound infections.
Daher, Riham; Pouget, Cassandra; Lavigne, Jean-Philippe; François, Patrice; Dunyach-Remy, Catherine ·
Scorpion venom peptides show translational promise across oncology (apoptosis induction, angiogenesis inhibition), neurology (ion channel modulation for pain and arrhythmias), and infectious disease (antimicrobial activity against MDR bacteria).
Dahiya, Ritu; Goyal, Kanika; Sharma, Kalicharan; Rawat, Aruna; Sharma, Vinita; Mathur, Pooja ·
Four high-affinity HLA-A*02:01-restricted peptides from HPV16 E6/E7 induced dendritic cell maturation, CD8+ T cell activation and proliferation, and potent antigen-specific cytotoxic T cell responses against tumor cells.
Dai, Jie; Yang, Rui; Cun, Yina; Zhang, Xinwen; Li, Jing; Shi, Lei; Zhou, Lili; Tao, Yufen; Shi, Li; Yao, Yufeng; Liu, Shuyuan ·
TX1 and TX3 analogs showed bactericidal activity with inhibition zones of 6.49-11.50 mm at 70-80 μg/mL against four bacterial species, while TX2, TX3, and TX5 showed fungicidal activity (7.23-10.23 mm zones) against A. niger and Fusarium.
Dalli, Kumari; Sadhanala, Trimurthulu; Govindappa, Nagendra; Kuruvalli, Gouthami; Vaddi, Damodara Reddy; Reddy, Aravinda Thippa; Jayaprakash, Gururaj Kudur ·
The tripeptide LRF showed ACE inhibitory potency five times greater than captopril (IC50 11.34 μM vs 63.06 μM), while several other peptides demonstrated dual ACE and DPP-IV inhibition with micromolar IC50 values.
Damen, Diala; Aboubacar, Hairati; Cournoyer, Aurore; Bazinet, Mathieu; de Toro-Martín, Juan; Gaaloul, Sami; Hamoudi, Safia; Cudennec, Benoit; Bazinet, Laurent ·
GLP-1 RA exposure was associated with increased scarring (90d: 1.5% vs 0.9%), postoperative pain (90d: 13.2% vs 10.6%), wound complications (90d: 1.7% vs 0.9%), and repeat surgery at 1 year (11.4% vs 9.5%) after trigger finger release.
Dameron, Laura S; Bank, Nicholas C; Raghava, Narayan; Himmelberg, Stephen; Knoll, Gregory M ·
Only 11 fMRI studies exist on GLP-1 RA effects on brain reward responses. Limited evidence suggests acute administration may reduce food cue reactivity in appetite and reward brain regions, but effects appear inconsistent and may attenuate with chronic treatment.
Dang, Vincent; Sambuco, Nicola; Yammine, Luba; Versace, Francesco ·
At 90 days, GLP-1 RA users had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p<0.05), with benefits persisting at 1 year for opioids, readmission, and mortality.
Dao, Matthew Q; Kim, Anika Y; Wang, Sarah; Won, Paul; Laspro, Matteo; Gillenwater, T Justin; Yenikomshian, Haig A; Johnson, Maxwell B ·
PRRT causes radiation nephropathy through renal reabsorption of radiolabeled peptides, with current mitigation strategies including amino acid co-infusion, receptor saturation, and cleavable linker technology showing promise for kidney protection.
Das, Abhirami; Kendi, Ayse Tuba; Manohar, Sandhya ·
Substituent modifications at the para-position of benzyl groups on amphipathic peptides produced notable effects on fibril formation, molecular packing, and immunogenicity in both cell culture and animal models.
Das, Anirban; Pramanik, Ushasi; Brown, Elise M; Liu, Chih-Yun; Gong, Huan; Fascetti, Jonathan; Gibson, Mark; Stealey, Samuel; Zustiak, Silviya P; Berkland, Cory; Sharma, Piyoosh; Jackrel, Meredith E; White, Mark A; Rudra, Jai S ·
Multiple therapeutic peptides (SS31, LPfFFD-PEG, SEN1576, α-sheet peptides, RI-OR2-TAT, TFP5, etc.) show anti-amyloid, anti-tau, and neuroprotective effects, with nanoparticle delivery significantly improving blood-brain barrier penetration and brain accumulation.
Das, Sandeep Kumar; Bashir, Bushra; Kolekar, Kaustubh Ajit; Harish, Vancha; Patle, Deepshikha; Vishwas, Sukriti; Mittal, Neeraj; Jha, Saurabh Kumar; Kumar, Puneet; Gupta, Gaurav; Dureja, Harish; Dua, Kamal; Chang, Dennis; Kuppusamy, Gowthamarajan; Singh, Sachin Kumar ·
First reported case of semaglutide-associated eosinophilic duodenitis causing high bowel obstruction, with endoscopic and histological confirmation of marked eosinophilic infiltration.
Davidts, S; Loumaye, A; Dano, H; Annet, L; Delire, B ·
Both GIPR agonism and antagonism reduced weight via decreased food intake in obese mice, but with distinct metabolic profiles: the agonist improved glucose tolerance independently of weight loss, while the antagonist produced more sustained appetite suppression but reduced insulin sensitivity.
Davies, Iona; Turland, Alexandra; Tran, Hanh Duyen; Wong, Carissa; Cahn, Olivier; Dunsterville, Cecilia; Sun, Yichang; Xiao, Yilin; Murphy, Kevin G; Bloom, Stephen R; Jones, Ben; Tan, Tricia M M ·
GLP-1RA use was associated with significantly higher 5-year incidence of adhesive capsulitis (HR up to 2.465), rotator cuff tears, and glenohumeral OA across all subgroups, but lower shoulder fracture risk in obese T2DM patients (HR 0.903).
Davis, William R; Bank, Nicholas C; Lauck, Bradley J; Creighton, Robert A; Mistovich, R Justin ·
Preclinical studies consistently demonstrate GLP-1 RAs reduce substance intake, attenuate reward-related behaviors, and suppress relapse-like responding across alcohol, nicotine, opioids, psychostimulants, and cannabinoids.
Dawid, Rosiejka; Joanna, Michałowska; Justyna, Marcickiewicz; Bogdańska, Adela; Błażejewska, Wiktoria; Szulińska, Monika ·