Real-world comparison shows liraglutide, metformin, naltrexone/bupropion, and phentermine-topiramate have different weight loss efficacy, side effects, and discontinuation rates in psychiatric patients.
4 AOMs compared in psychiatric patientsReal-world comparison of weight loss drugs in a population with unique treatment challenges
What the researchers found
Comparative effectiveness analysis of four anti-obesity medications in psychiatric patients revealed differences in weight loss, adverse events, and early discontinuation rates in this understudied population.
Why it matters
Psychiatric patients face unique challenges with weight management — their medications cause weight gain, some drugs interact with psychiatric medications, and mental health conditions affect adherence. Evidence specific to this population is critical.
How the study worked
Retrospective observational cohort study comparing liraglutide, metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric outpatients.
What this study cannot tell us
Retrospective observational design; selection bias likely; short-term outcomes only; psychiatric diagnoses and medications not standardized across groups.
How to read the evidence
Retrospective observational study — provides needed real-world data but cannot prove comparative superiority.
When this study was published
Published in 2026, addressing a critical evidence gap in psychiatric obesity management.
The bigger picture
As obesity treatment becomes more personalized, understanding how weight loss drugs perform in specific populations like psychiatric patients is essential for equitable, effective care.
Questions still open
- How do newer GLP-1 drugs (semaglutide, tirzepatide) perform in psychiatric populations compared to liraglutide?
- Do specific psychiatric medications predict better response to certain weight loss drugs?
Common questions
Why do psychiatric patients need special weight loss drug studies?
Which weight loss drug works best for psychiatric patients?
Read the original research
Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients.
Therapeutic advances in psychopharmacology, 16, 20451253261419609
Citation
Choi, Won-Seok; Song, Min-Kyu; Seo, Mansuk; Woo, Young Sup; Bahk, Won-Myong. (2026). Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients.. Therapeutic advances in psychopharmacology, 16, 20451253261419609. https://doi.org/10.1177/20451253261419609