Browse more peptide research, methods and limitations.
EsMETTL3 catalyzes m6A RNA methylation that regulates antimicrobial peptide expression through the Toll signaling pathway in Chinese mitten crabs.
Chen, Jinming; Li, Yang; Hao, Qingding; Xu, Chaohui; Sheng, Guoqin; Zhou, Kaimin; Li, Weiwei; Wang, Qun; Zhu, Youting ·
The substance P/NK1R system is involved in central sensitization in chronic pain, as demonstrated in a spared nerve injury mouse model.
Chen, Juan; Lai, Yimin; Li, Wei ·
GLP-1 RAs demonstrated cardiorenal benefits over DPP4 inhibitors in patients aged ≥80 with T2DM, extending the evidence base to the very elderly population.
Chen, Jui-Cheng; Fang, Yu-Wei; Liu, Ya-Fang; Chen, Mon-Ting; Tsai, Ming-Hsien ·
The study evaluated NAION risk in GLP-1 RA users compared to other antidiabetic drug users and SGLT2i users specifically in a large real-world T2DM population.
Chen, Jun-Wei; Yu, Frederick Tzu-En; Chen, Hsin-An; Huang, Tzu-Fu; Chen, Harn-Shen; Wu, Tzu-En ·
The systematic review and meta-analysis critically assessed the semaglutide-NAION association, synthesizing all available evidence to quantify the risk.
Chen, Kai-Yang; Chan, Hoi-Chun; Chan, Chi-Ming ·
Semaglutide improved attention and memory in depressed patients without significantly improving depressive symptoms, suggesting separate cognitive and mood pathways.
Chen, Mu-Hong; Bai, Ya-Mei; Tsai, Shih-Jen ·
Semaglutide affected vessel morphology in the chicken CAM model, providing experimental evidence that may relate to reported ocular and reproductive safety signals.
Chen, Pei-Hsuan; Abood, Samar; Bloom, Steven ·
A Scleractinia-derived neuropeptide suppressed PTZ-induced seizures and improved recognition memory by modulating NPY-Y1R signaling in mice.
Chen, Qian; Deng, Congshuang; Huang, Xiaoshan; Wang, Aili; Xu, Nan; Cao, Kaixun; Yang, Min; Li, Shang; Lu, Qiumin; Gong, Guiyi; Lee, Simon Ming-Yuen ·
A structured multi-dimensional comparison of five long-acting GLP-1RAs in China provides evidence-based rankings for clinical preference and institutional formulary decisions.
Chen, Qiying; Chen, Tianyu; Lin, Weicheng; Chen, Xi ·
AI-assisted annotation identified 7 dual-function peptides in Hericium erinaceus with confirmed antioxidant and ACE-inhibitory activities through laboratory validation.
Chen, Rongheng; Yu, Jiahao; Feng, Simin; Shao, Ping ·
cfDNA-LL37 immune complexes resist DNase degradation and amplify inflammation; disrupting these complexes before DNase treatment is required for effective inflammation control.
Chen, Shi; Du, Yibo; Zhu, Chenxu; Li, Chuang; Liu, Xingliang; Liu, Lixin; Chen, Yongming ·
Biased and unbiased GLP-1R agonists produce spatially diffuse cAMP signaling in beta cells despite differences in receptor internalization and localization, challenging location-dependent signaling theories.
Chen, Shiqian; Lobato, Carolina B; Wong, Carissa; Manchanda, Yusman; Viloria, Katrina; Davies, Iona; Andersen, Daniel B; Ast, Julia; Sloop, Kyle W; Hodson, David J; Broichhagen, Johannes; Bloom, Steve; Holst, Jens J; Tan, Tricia; Tomas, Alejandra; Jones, Ben ·
Stapled peptide inhibitors of VGLL4-TEAD4 interactions accelerated cutaneous wound healing by activating fibroblast proliferation through the Hippo pathway.
Chen, Shuai; Gai, Conghao; Wang, Guangyao; Dong, Peng; Zhuo, Xiaobin; Zhang, Wenwen; Zhang, Pei-Chao; Chai, Xiaoyun; Xue, Hongjuan; Su, Juan; Zhao, Qingjie; Zou, Yan ·
Gut microbiota dysbiosis contributes to T1D through metabolic disruption of gut barrier integrity and molecular mimicry where microbial peptides trigger cross-reactive autoimmune responses against beta cells.
Chen, Sihan; Luo, Yixin; Wei, Gaoyang; Liu, Shuiping ·
AMPLiT identified antimicrobial peptides from ancient human coprolite metagenomes with high accuracy (AUPRC 0.9486), revealing potentially extinct but efficacious AMPs.
Chen, Sizhe; Yuan, Yue; Wang, Yun; Peng, Ye; Tun, Hein Min; Jiang, Zhimin; Miao, Yinglei; Lee, Sunjae; Yin, Xiaole; Shen, Xiaotao; DeLeon, Orlando; Chang, Eugene B; Chan, Francis Ka Leung; Sun, Yang; Ng, Siew Chien; Su, Qi ·
Network meta-analysis comparing HFpEF therapies suggests adiposity-targeting approaches are central to treatment, with emerging metabolic therapies showing comparative effectiveness.
Chen, Szu-Han; Tseng, Yu-Wen; Huang, Chi-Jung; Yang, Shu-Mei; Fudim, Marat; Chuang, Shao-Yuan; Sung, Shih-Hsien; Cheng, Hao-Min ·
Bitter gustatory receptors in Coptotermes formosanus modulate immune responses against M. anisopliae, revealing a novel taste-immunity axis in termite defense.
Chen, Weiwen; Zhang, Shijun; Li, Zhiqiang ·
PA/GL13K self-assembled hydrogel achieves sustained antimicrobial peptide release in periodontal pockets through charge-complementary interactions, effectively treating periodontitis.
Chen, Wener; Zhan, Chaoning; Zhang, Chengfei; Aparicio, Conrado; Peng, Simin; Ye, Zhou; Lin, Yifan ·
Short-term CSII intensive therapy improved cardiometabolic index levels in newly diagnosed T2DM patients, with CMI changes correlating with insulin resistance reduction.
Chen, Xia; Li, Shuya; Chen, Zeren; Wang, Dong; Yang, Ling; Deng, Xia; Li, Haoxiang ·
CMP-functionalized micelles successfully deliver drugs to diseased chondrocytes using a dual-targeting approach: collagen adhesion and MMP-13-activated cell penetration.
Chen, Xiao; Zhou, Dongyang; Wang, Jian; Liu, Han; Zhang, Hao; Geng, Zhen; Wang, Guangchao; Shen, Hao; Zhang, Yuanwei; Li, Zuhao; Wang, Dongliang; Ren, Xiaoxiang; Wang, Xiuhui; Xu, Ke; He, Chongru; Bai, Long; Wei, Yan; Chen, Xiaoyuan; Su, Jiacan ·
HMLT, a histidine-substituted melittin derivative, ameliorates SAP by restoring oxidative homeostasis and macrophage metabolism with significantly reduced cytotoxicity versus native melittin.
Chen, Xiaolong; Chen, Ya; Mao, Yunyun; Chen, Xinxin; Zhou, Yilin; Tu, Jianfeng ·
Semaglutide provided neuroprotection after TBI by inhibiting caspase-dependent neuronal apoptosis, resulting in improved cognitive function in mouse models.
Chen, Xiyu; Zhang, Bin; Yang, Mengshi; Zhuang, Yuan; Liao, Xixian; Shi, Guangzhi ·
Optimized 68Ga-DOTA radiolabeling conditions were established for DDMPs and AAMPs, overcoming challenges that prevented standard protocols from achieving adequate labeling efficiency.
Chen, Xueyao; Zhang, Siqi; Jiang, Shuo; Hu, Kuan ·
Sequential release of ribosome-targeting AMP followed by irisin from a MOF-based system addresses infection, inflammation, and bone loss in periodontitis comprehensively.
Chen, Yan; Xu, Zheng; Xue, Yunmo; Liu, Shanshan; Zhang, Xiang; Guo, Jingyao; Yao, Minhui; Liu, Yue; Lu, Xiaolin; Qian, Jieshu; Ma, Qian ·
A radiotherapy-responsive peptide hydrogel enables pulsatile release of mRNA-LNPs synchronized with radiation, synergizing with immune activation to prevent breast cancer recurrence.
Chen, Yanbin; Cai, Xiaoyao; Lan, Dingxuan; Zou, Lanbing; Lyu, Chaoyi; Mu, Ganen; Yang, Lijun; Jia, Haixue; Liu, Jianfeng; Yang, Cuihong ·
Engineered micropatch enables oral delivery of heterophyllin B, a cyclic plant peptide that alleviates T2DM by modulating hepatic IRS2/PI3K-Akt/FoxO1 signaling and restoring bile acid metabolism.
Chen, Yi; Huang, Yuanxing; Huang, Cheneryu; Zhang, Shu; Fan, Mengyu; Yuan, Xu; Huang, Cao; Zhang, Man; Peng, Jianqing; Sun, Runbin; Zhang, Shuai; Chen, Wenzhang; Gong, Zipeng ·
The meta-analysis evaluated GLP-1RA adjunctive therapy effects on cardiometabolic risk factors in T1DM across available RCTs, extending evidence beyond the established T2DM indications.
Chen, Yizhu; Tang, Yufei; Yue, Rui; Yang, Bo; Wang, Ai; Long, Yang; Xu, Yong; Gao, Chenlin ·
HSD3B regulates maternal care behavior in wolf spiders through neuropeptide signaling pathways, providing an additional mechanism beyond previously known hormonal regulation.
Chen, Yunru; Xu, Tianhong; Wang, Jingting; Wang, Yuan; Yu, Na; Chen, Tao; Liu, Zewen ·
LEAP2 expression varies with feeding state and body weight in broilers, and intraperitoneally injected LEAP2 modulates feed intake in chicks, confirming its role in avian appetite regulation.
Chen, Z; Liu, L; Shu, X; Wang, H; Xu, B; Zhang, J; Wang, M; Shen, M; Zheng, X; Chen, J ·
RFP@TVYV amphiphilic peptide nanocarrier achieves macrophage-targeted delivery and intracellular MRSA eradication through sequential targeting using tuftsin modification.
Chen, Zaipeng; Wu, Yuling; Nie, Zhiqiang; Mao, Tengfei; Tao, Junjun; Tang, Changming; Ruan, Huajun; Lang, Xin; Zhou, Wei; Lu, Jiaju; Li, Xigong ·
Methionine-to-cysteine dietary ratios modulate broiler growth and intestinal development through altered brain-gut peptide secretion patterns identified via proteomic analysis.
Chen, Zhihui; Zhao, Yang; Chai, Haoliang; Zhao, Dexin; Xu, Liangmei; Teng, Teng ·
SGHC-WR hydrogel with WR3-NH2 antimicrobial peptide demonstrated triple function: antibacterial activity, anti-inflammatory effects, and pro-healing tissue regeneration in wound models.
Chen, Zhizhi; Li, Chao; Wang, Lei; Luo, Ying; Yang, Yahan; Han, Qinqin; Zhang, Jinyang; Shi, Yaoqiang; Sun, Yi; Song, Yuzhu ·
mRNA-mediated expression of fusion phage tail-AMP proteins inside macrophages enables targeted intracellular clearance of M. tuberculosis, overcoming the limitations of extracellular-focused anti-TB drugs.
Chen, Ziwei; Fan, Xueting; Zhou, Liying; Zou, Lihui; Wan, Li; Li, Yayu; Li, Chang; Kuai, Lu; Cai, Jiahui; Zhang, Lili; Li, Yifei; Li, Hexin; Wan, Kanglin; Liu, Haican; Xu, Hongtao; Xiao, Fei ·
GLP-1 RA use was associated with lower incident epilepsy risk compared to DPP-4i use in adults with T2DM, providing real-world evidence supporting preclinical neuroprotective findings.
Cheng, Ching-Yang; Lo, Shih-Chang; Huang, Chien-Ning; Yang, Yi-Sun; Wang, Yu-Hsun; Kornelius, Edy ·
GIP functions as an appetite regulator rather than a hypoglycemic incretin in grass carp, raising blood glucose and modulating feeding behavior — opposite to its mammalian role.
Cheng, Danhong; Sun, Manjie; Huang, Jinqian; Luo, Shan; Chen, Haotian; Jin, Shengzhen; Zhang, Yanpeng; Yuan, Xiaochen ·
The pilot study compared changes in pancreatic fat fraction between calorie restriction and liraglutide over 24 weeks, with secondary analysis of weight, liver fat, and glycemic parameters.
Cheng, Haiyan; Jiang, Xiao; Zhu, Xiaowei; Zhu, Xiaowen; Li, Chenxi; Cao, Mengjiao; Zhou, Qunyan; Deng, Shukun; Wu, Wenjun ·
SIPPC platform enables oral peptide delivery through self-assembly into protective nanoparticles that are triggered to release their peptide cargo by ROS at inflammatory gut sites.
Cheng, Juan; Wu, Peng; Li, Chenwen; Han, Ying; Sun, Menglong; Dou, Yin; Chen, Sheng; Zhang, Jianxiang ·
PfCC biomimetic platform combines antimicrobial peptide-functionalized cancer cell membrane camouflage with endogenous H2S-activated photothermal immunotherapy for colorectal cancer.
Cheng, Kai; Zhang, Fang; Zou, Jia-Hua; Lei, Xiao-Ling; Xie, Xiao-Ting; Guo, Yan-Bin; Wang, Guo-Ping; Liu, Bo; Zhao, Yuan-Di; Xia, Jiang; Fan, Jin-Xuan ·
Puerarin ameliorates T2D glucose and lipid metabolism through gut microbiota homeostasis restoration and adipose tissue thermogenesis promotion.
Cheng, Long; Gan, Minghong; Wang, Huiyang; Song, Yanru; Bai, Yang; Zhang, Dongfang ·
Bilayer PL@SAMT/Mg hydrogel coating provides pH-triggered controlled antibacterial release and sustained lubrication for infection-resistant urinary catheters.
Cheng, Ming; Lin, Weijie; Yu, Jianbo; Gao, Peiliang; Shi, Fange; Wang, Chunyu; Ma, Yong; Liu, Zhongdi; Dong, Guiying ·
Increasing GLP-1 RA use has expanded gastric ultrasound utility, but 2-5% of exams yield indeterminate results that require knowledge of troubleshooting pitfalls beyond standard antral assessment.
Cheng, Peter; Perlas, Anahi; Girón-Arango, Laura ·
RL-RF10 promotes gingival tissue repair and regeneration through the integrin αvβ3/p38/Snail1 axis, representing the first potential specific medication for gum tissue restoration.
Cheng, Tingting; Zhou, Jianzhong; Yang, Haoran; Zhao, Anna; Chen, Yuxiang; Xianqi, Rao; Li, Jing; Li, Lin; Yang, Xinwang; Li, Ziliang ·
Multi-database pharmacovigilance analysis using advanced signal detection identified and characterized ocular toxicity signals associated with GLP-1 RAs across both FAERS and VigiBase.
Cheng, Xiao; Jiang, Ziwei; Li, Guangyao; Wang, Jiawei; Han, Furong ·
Deep learning methods increasingly outperform traditional approaches for CD8+ T-cell epitope prediction, with various architectures showing improved accuracy for identifying immune-activating peptides.
Cheng, Xiaorui; Wu, Haixia; Chen, Pengji; Liu, Rui; Lei, Yuanyuan; Mei, Hu; Wang, Pingqing ·
4D LAQ technology effectively evaluates LA volume, function, and strain in HFpEF, with circumferential strain providing additional diagnostic value in this patient population.
Cheng, Yuehong; Zhang, Lijuan; Li, Lei; Fei, Mengyao; Wang, Yao; Zhang, Pingyang ·
KLH3 and KLH4 histidine-modified peptides show pH-dependent selective activity against gram-negative bacteria, becoming active battering rams against bacterial membranes only at acidic infection sites.
Cheon, Dae Hee; Choi, Yoonhwa; Arya, Rekha; Hur, Yuna; Choe, Hyeong Woon; Nam, So Hee; Hyun, Soonsil; Chaurasia, Akhilesh Kumar; Yu, Jaehoon; Kim, Kyeong Kyu; Lee, Yan ·
Current strategies including PEGylation, lipidation, nanoformulation, and advanced delivery systems can effectively address the chemical instability, short half-life, and poor bioavailability of peptide drugs.
Cheshomi, Mahsa; Shobeiri, Nikta; Tajani, Amineh Sadat; Khameneh, Bahman ·
Network meta-analysis compared CPAP, GLP-1 RAs, and combination therapy for OSA, evaluating the primary endpoint of AHI along with sleepiness and metabolic outcomes.
Chiappa, Gaspar R; Santos, Paula C N; Cavalcante, Deivyd Vieira Silva; Sá Filho, Alberto Souza; Prado, Natalia; Lombardo, Katia Marques; Sequero, Pedro Sanchez; Esquinas, Antonio M ·
DNP-V cyclic peptide carrier enables efficient oral delivery of zinc-stabilized insulin hexamers with rapid, robust, and sustained glycemic efficacy in diabetic mice.
Chikamatsu, Shoma; Sakaguchi, Kosei; Michigami, Masataka; Araki, Kimi; Kume, Shoen; Tokuyasu, Midori; Masuda, Takeshi; Fujii, Ikuo; Ohtsuki, Sumio; Ito, Shingo ·
Antimicrobial peptides directly inhibit tau protein aggregation and modulate Alzheimer's pathology, supporting their dual role as anti-infective and anti-neurodegenerative agents.
Chinnathambi, Subashchandrabose; Rangappa, Nagaraj; Malik, Sneha ·