Browse more peptide research, methods and limitations.
HFrEF accounts for approximately half of all heart failure cases, with diagnosis relying on natriuretic peptide levels, cardiac imaging, and clinical signs/symptoms.
Cannata, Antonio; Crespo-Leiro, Maria Generosa; Bromage, Daniel I; Ruschitzka, Frank; McDonagh, Theresa A ·
Tumors hijack an interorgan nociceptor-SLIT2-CGRP neural circuit to drive systemic immunosuppression, and disrupting this loop restores T-cell function and enhances immunotherapy efficacy.
Cao, Canhui ·
SC17-2 peptide from high-altitude frog N. parkeri evolved from antimicrobial to angiogenic and cell migration-promoting functions, representing adaptation to extreme UV environments on the Tibetan Plateau.
Cao, Kaixun; Zhang, Liting; Yang, Min; Gao, Jinai; Deng, Congshuang; Huang, Xiaoshan; Chen, Qian; Lu, Qiumin; Cheng, Yizhe; Gao, Shaoyang; Cao, Hui; Lai, Ren ·
Systematic review and meta-analysis of RCT safety data evaluates the association between GLP-1 RA use and spontaneous reports of musculoskeletal adverse events.
Cao, Meng; Lin, Chu; Cai, Xiaoling; Lv, Fang; Yang, Wenjia; Ji, Linong ·
GLY-200, an oral non-absorbed polymeric drug emulating duodenal exclusion, showed additive metabolic and weight loss effects when combined with GLP-1 receptor agonists.
Carlson, Taylor L; Fineman, Mark; Kernodle, Stace; Hutch, Chelsea R; Bryant, Christine; Colbert, Kevin; Seeley, Randy J; Nimgaonkar, Ashish ·
Semaglutide demonstrates potential neuroprotective effects but may influence psychological functioning, with reports of psychopathological symptoms including mood changes in some patients.
Carminati, Matteo; Tondello, Mattia; Concina, Arianna; Olgiati, Paolo; Zanardi, Raffaella ·
The synergy of antimicrobial peptides, nanotechnology delivery systems, and computational design offers promising new therapeutic strategies against MDR and XDR tuberculosis.
Carnero Canales, Christian S; Marquez Cazorla, Jessica Ingrid; Marquez Cazorla, Renzo Marianito; Santos, Aline Martins Dos; Lobato Duarte, Jonatas; Oliveira Catarin Nunes, Letícia; Reis, Túlio Custódio; Cerazi Salvador, Lara; Santos-Filho, Norival Alves; Sábio, Rafael Miguel; Santos, Hélder A; Pavan, Fernando Rogério ·
Anti-CGRP monoclonal antibodies demonstrated sustained effectiveness at 24 months with significant reduction in monthly headache days, and baseline factors predicting 2-year treatment persistence were identified.
Caronna, Edoardo; Mas-de-Les-Valls, Rut; Egeo, Gabriella; Millán Vázquez, Manuel; Nieves-Castellanos, Candela; Portocarrero-Sánchez, Leonardo; Vaghi, Gloria; Rodríguez-Montolio, Joana; Jaimes, Alex; Muñoz-Vendrell, Albert; Oliveira, Renato; Polanco, Marcos; González Osorio, Yesica; Canales, Javiera; Ornello, Raffaele; Thunstedt, Cem; Fernández-Lázaro, Iris; Husøy, Andreas; Sánchez-Soblechero, Antonio; Nunes Vicente, Beatriz; Riesco, Nuria; Flores Pina, Belén; Fernandes, Catarina; Lopez, Alberto Andres; Martins-Silva, Elisa; Budrewicz, Sławomir; Gallardo, Víctor José; Gómez Dabó, Laura; Torres-Ferrus, Marta; Alpuente, Alicia; Torelli, Paola; Aurilia, Cinzia; Lamas, Raquel; Ruiz Castrillo, Maria José; De Icco, Roberto; Sances, Grazia; Broadhurst, Sarah; Winstanley, Jed; Gómez, Andrea; Campoy, Sergio; Marques, Inês; Parreira, Elsa; Gárate, Gabriel; Pascual, Julio; Guerrero Peral, Angel Luis; Caponnetto, Valeria; Straube, Andreas; Gonzalez-Martinez, Alicia; Quintas, Sonia; Sánchez-Del-Río, Margarita; Tronvik, Erling; Venegas Pérez, Begoña; Oterino Duran, Agustín; Rodrigues, Miguel; Cevoli, Sabina; Colombo, Bruno; Trimboli, Michele; Frediani, Fabio; d'Onofrio, Florindo; Aguggia, Marco; Salerno, Antonio; Carnevale, Antonio; Zucco, Maurizio; Albanese, Maria; Finocchi, Cinzia; Ranieri, Angelo; Zoroddu, Francesco; Autunno, Massimo; Sanahuja, Jordi; Waliszewska-Prosół, Marta; Pereira, Liliana; Layos-Romero, Almudena; Luzeiro, Isabel; Dorado, Laura; Alvarez-Escudero, Rocio; Martins, Isabel Pavao; Sundal, Christina; Irimia, Pablo; Lozano Ros, Alberto; Gago-Veiga, Ana Beatriz; Juanes, Fernando Velasco; Ruscheweyh, Ruth; Sacco, Simona; García-Azorín, David; González-Quintanilla, Vicente; Gil-Gouveia, Raquel Santos; Huerta Villanueva, Mariano; Rodríguez-Vico, Jaime; Lasaosa, Sonia Santos; Ghadri-Sani, Mona; Tassorelli, Cristina; Díaz De Terán Velasco, Francisco Javier; Diaz-Insa, Samuel; González Oria, Carmen; Barbanti, Piero; Pozo-Rosich, Patricia ·
Dc1 antimicrobial peptide from D. columbianus frog skin demonstrates immunomodulatory and tissue repair potential in addition to its established antimicrobial activity.
Cassimiro, Isabella S; Ferreira, Bruno A; Deconte, Simone R; Lima, Taís C; Moura, Francyelle B R; Castro, Mariana S; Araújo, Fernanda A ·
Bioinformatically selected human AMPs demonstrated antimicrobial activity against Bacteroidota species associated with oral disease, suggesting potential alternatives to conventional antibiotics for periodontal infections.
Castagliuolo, Giusy; Notomista, Eugenio; Sordillo, Alessia; Barone, Laura; Antonini, Dario; Renzi, Francesco; Zanfardino, Anna; Varcamonti, Mario ·
FAERS analysis and Google Trends data reveal a potential safety signal linking tirzepatide to NAION, warranting further pharmacovigilance and clinical investigation.
Castellana, Eleonora; Chiappetta, Maria Rachele ·
Comprehensive review of traditional and new-generation diabetes agents documents expanding off-label weight loss use driven by GLP-1 RA efficacy and the growing overlap between diabetes and obesity treatment.
Castellana, Eleonora; Budau, Patricia Madalina; Chiappetta, Maria Rachele ·
CAQK selectively accumulated at the spinal cord injury site after intravenous injection, demonstrating dose-dependent targeting with the medium dose (1.0 mg/kg) showing optimal localization.
Castillo, Jose A; Le, Michael Nhien; Huang, Kuan-Wei; Pivetti, Christopher; Vatoofy, Sina; Ratcliff, Amanda; Tran, Taylor; Bannerman, Solomon; Lee, Maya; Shahin, Mehrad; Loll, Emma; Clark, Kaitlin; Reynolds, Elizabeth; Dangan, Andrei M T; Uppuluri, Jay; Urreola, Gabriel; Wang, Aijun A; Russo, Rachel M ·
Tooth bleaching with hydrogen peroxide-based systems altered neuropeptide Y levels in dental pulp, with differences between the three commercial systems tested, suggesting NPY plays a role in post-bleaching inflammation and sensitivity.
Caviedes-Bucheli, Javier; Ríos-Osorio, Néstor; Pérez-Villota, Mario; Aucú-Miño, Karolina; Escobar-Mafla, Diana; Muñoz-Alvear, Hernán Darío; Gomez-Sosa, José Francisco; Diaz-Barrera, Luis; Güiza-Cristancho, Edgar; Munoz, Hugo Roberto ·
Galcanezumab treatment was associated with changes in inflammatory cytokine profiles in migraine patients, suggesting the drug may have anti-inflammatory effects beyond CGRP blockade.
Ceccardi, Giulia; Rao, Renata; Schiano di Cola, Francesca; Fiducia, Beatrice; Tolassi, Chiara; Quaresima, Virginia; Mattioli, Irene; Eshja, Klaudia; Cresta, Elena; Gipponi, Stefano; Pilotto, Andrea; Padovani, Alessandro ·
GLP-1 receptor analogs demonstrate evidence of improving both metabolic dysfunction (insulin resistance, weight) and reproductive outcomes (androgen levels, ovulation) in women with PCOS and obesity.
Celik, Ozlem; Yazici, Dilek; Ciudin, Andreea; Macut, Djuro; Micic, Dragan; Yumuk, Volkan; Yildiz, Bulent Okan ·
WHO now formally recommends GLP-1 therapies as part of integrated, person-centered obesity treatment, recognizing obesity as a chronic disease requiring lifelong management beyond behavioral interventions alone.
Celletti, Francesca; Farrar, Jeremy; De Regil, Luz ·
European sea bass beta-defensins (bdef1 and bdef2) are upregulated by betanodavirus infection and possess direct antiviral activity in addition to their known antibacterial functions.
Cervera, Laura; Valero, Yulema; Hernández-Ariola, Elena; Cárdenas, Constanza; Guzman, Fanny; Mercado, Luis; Chaves-Pozo, Elena; Cuesta, Alberto ·
The pooled analysis of 19 RCTs with 51,557 participants assessed semaglutide's impact on peripheral limb events, providing the most comprehensive evidence to date on this important but understudied outcome.
Cesaro, Arturo; Acerbo, Vincenzo; Longo, Miriam; Antonucci, Alessandra; Maiorino, Maria Ida; Monaco, Maria Grazia; Martelli, Eugenio; Giudice, Giorgio; Esposito, Katherine; Giorgino, Francesco; Federici, Massimo; Calabrò, Paolo ·
Microbial fermentation of plant foods produces bioactive compounds including peptides and transformed polyphenols that improve glycemic control through multiple pathways including enhanced GLP-1 signaling and insulin sensitivity.
Cevallos-Fernández, Emilia; Beltrán-Sinchiguano, Elena; Jácome, Belén; Quintana, Tatiana; Rivera, Nadya ·
TMAO had a higher AUC than BNP for discriminating acute decompensated from stable heart failure, establishing it as a potential novel biomarker for detecting heart failure worsening.
Ceylan, Yemlihan; Kaya, Muhammed; Saygın, Murat; Alp, Hamit Hakan ·
Cath-Ka is the first identified frog-derived TLR2/TLR4 agonist that activates macrophage antimicrobial functions through the MyD88 signaling pathway, enhancing bacterial killing.
Chai, Jinwei; Wu, Jiena; Zhang, Shuiying; Zhang, Wenjun; Xiong, Weichen; Li, Jinqiao; Nguyen, Tienthanh; Shu, Lixia; Kotsyfakis, Michail; Chen, Xin; Xu, Xueqing ·
Signal-biased dual GLP-1/GIP receptor agonism with CT-388 produced superior weight loss compared to unbiased agonism in preclinical models, with supportive early clinical data in obesity.
Chakravarthy, Manu V; Rodriguez, Ruben; Hergarden, Anne; Elliott, Michael A; Frias, Juan P; Argüelles-Tello, Federico A; Tenorio, Edgar; Rankin, Jonathan E; Wu, Jingtao; Krishnan, Shyam; Erlanson, Daniel A; Fucini, Raymond V; Bone, Derek; Iwig, Jeffrey S; Acosta, Luis; Untereiner, Ashley; Pant, Asmita; Patton, Avalon; Sanchez-Sanchez, Leyla L; Luo, Jian; Steinberg, Alexandra; Bialonczyk, Damian; Hansen, Stig K ·
CT-868 demonstrated glycemic efficacy as a signal-biased dual GLP-1/GIP agonist in type 2 diabetes, with both dose levels showing HbA1c improvements over 26 weeks.
Chakravarthy, Manu V; Elliott, Michael A; Acosta, Luis; Sonnenberg, Gabriele E; Bialonczyk, Damian; Wu, Jingtao; Argüelles-Tello, Federico A; Garcia-Reza, Raymundo; González-González, José Gerardo; Hansen, Stig K; Frias, Juan P ·
The IDF guidelines reaffirm glycemic control as the cornerstone of T2D management while recognizing SGLT2i and GLP-1 RA cardiovascular-kidney benefits, particularly emphasizing equitable access in LMICs.
Chan, Juliana C N; Deerochanawong, Chaicharn; Khunti, Kamlesh; Hassanein, Mohamed; Mohan, Viswanathan ·
Concurrent GLP-1 receptor agonist use at immune checkpoint inhibitor initiation was associated with mortality and immune-related adverse events in cancer patients with type 2 diabetes.
Chan, Shan-Ho; Li, Pei-Yun; Li, Pin-Hung; Lin, Yu-Jung; Wang, Wei-Hsun; Huang, Yu-Nan; Chen, Jia-Yuh ·
Incretin-based dual and triple agonists demonstrate enhanced weight loss compared to single-receptor approaches, with the meta-analysis quantifying efficacy and safety across available RCTs.
Chan, Zhi Hong; Omar, Abdousamad Said; Gill, Kieran; Volucke, Gabriele; Azhar, Muhammad Muneeb; Haleem, Syed Mohammad; Sia, Jian En; Rahman, Obaid Ur; Ahmad, Moaz; Shahid, Nuraan; Gardezi, Syed Anjum; Joseph, Kevin Vinod; Behary Paray, Nitish; Zulfiqar, Eeshal ·
Antimicrobial peptides, including amyloid-beta, function as components of brain innate immunity against microbial invasion, supporting the infectious/antimicrobial hypothesis of Alzheimer's disease.
Chandrashekar, Madhura; Velmurugan, Gowshika; Mishra, Amit; Chinnathambi, Subashchandrabose ·
Six patients developed DLRPN after GLP-1 RA use, with all showing substantial weight loss (35-52 lbs) and rapid HbA1c decline, suggesting rapid glycemic correction as the trigger mechanism.
Chandrashekhar, Swathy; Davalos, Long; Pradhan, Richeek; Paul, Pritikanta ·
The study compared incident anxiety and insomnia rates between SGLT2 inhibitor users and other antihyperglycemic agent users in type 2 diabetes, providing comparative mental health safety data.
Chang, Chen-I; Lin, Jun-Fu; Chen, I-Chieh; Lin, Ching-Heng; Chen, Hsin-Hua; Chang, Ming-Hong; Tang, Chien-Lun; Pai, Yen-Wei ·
A protocol-driven remote management program for SGLT2i and GLP-1 RA prescribing in high-risk T2D patients demonstrated acceptable safety with manageable adverse events.
Chang, Lee-Shing; Hassan, Shahzad; Chasse, Jacqueline; Stern, Gretchen; Gabovitch, Daniel; Zelle, David; Colling, Caitlin; Crossen, Jennifer; Aronson, Samuel J; Oates, Michael; Figueroa, Christian; Collins, Emma; Ruggiero, Ryan; Plutzky, Jorge; Gaziano, Thomas A; Cannon, Christopher P; Wexler, Deborah J; Scirica, Benjamin M; Blood, Alexander J ·
GLP-1 receptor agonist use was not associated with increased depression risk compared to SGLT2 inhibitor use in a propensity-matched cohort of overweight/obese T2D patients.
Chang, Yu; Hsieh, Ming-Hong; Ju, Po-Chung; Chang, Cheng-Chen ·
The rapid expansion of GLP-1 drug use for obesity necessitates careful attention to side effects, long-term outcome data, and protection against unregulated products.
Chao, Ariana M; Gilden, Adam; Wadden, Thomas A ·
Rimegepant 75 mg demonstrated efficacy and safety for acute migraine treatment in Black or African American adults, addressing a critical evidence gap from clinical trial underrepresentation.
Charleston, Larry; Armand, Cynthia E; Monteith, Teshamae S; O'Brien, Hope L; Abbott, Chandra C; Pixton, Glenn C; Fullerton, Terence ·
Rimegepant effectively treats migraine without constricting cerebral or extracerebral arteries, as demonstrated by longitudinal MRI angiography during spontaneous attacks.
Chaudhry, Basit Ali; Younis, Samaira; Al-Mashat, Hassan; Gozalov, Emil; Amin, Tariq Mohammad; de Koning, Patrick J H; Larsson, Henrik Bo Wiberg; Amin, Faisal Mohammad ·
Circadian regulation of m6A RNA methylation may modulate neuronal excitability and pain signaling in migraine, explaining the well-known time-of-day patterns of attack onset.
Chauhan, Shikha Baghel; Bhandari, Ayushi; Jain, Chirag; Singh, Indu ·
LC-HRMS analysis identified specific degradation products and pathways for afamelanotide, providing comprehensive stability profiling for this critical orphan drug.
Chawathe, Ashwini; Sharma, Nitish ·
Recombinant live biotherapeutics offer a novel platform for in-body peptide drug biosynthesis and precision delivery, potentially overcoming key limitations of traditional peptide therapeutics.
Chawla, Meenal; Bhange, Omkar; Das, Bhabatosh ·
GLP-1RAs reduce albuminuria through multiple mechanisms beyond glycemic control, including blood pressure reduction, weight loss, and anti-inflammatory effects, supporting their role in kidney protection for T2D patients.
Checa-Ros, Ana; Okojie, Owahabanun Joshua; Wassouf, Jacob Gabriel; Yedean, Aida; Hsueh, Wei-Chung; Hebda, Patryk; Llobell, Esther Rodriguez; Muhmenthaler, Greta Bianca; Tran, Martin Duc-Duy; D'Marco, Luis ·
Black, Hispanic, and lower-socioeconomic-status patients were less likely to receive GLP-1 prescriptions for obesity within a university-based HMO, consistent with national disparity patterns.
Chen, Alissa S; Brunetto, Wendy; Canavan, Maureen E; Lipska, Kasia J; Richey, Elizabeth; Wilson, Madeline S; Zarro, James; Ross, Joseph S ·
Lu-177-DOTATATE PRRT demonstrated manageable toxicity and efficacy in 7 patients with recurrent neuroendocrine tumor liver metastases post-liver transplantation while on everolimus immunosuppression.
Chen, Chiyi; Zheng, Qiming; Zhang, Li; Guo, Qingjun; Wang, Honghai; Sun, Jisan; Xie, Yan; Jiang, Wentao ·
This protocol establishes a rigorous framework to test whether GLP-1RAs reduce smoking in T2DM patients, with fMRI to explore neural reward pathway mechanisms.
Chen, Da; Li, Ziyi; Zhou, Chenxia; Li, Ruoxuan; Ji, Xinnan; Feng, Bo; Song, Jun ·
VIP-modified defect-engineered ZnOx-Au-NaBH4 nanoparticles selectively induce pyroptosis in fibroblast-like synoviocytes, demonstrating targeted cell killing for RA therapy.
Chen, Han; Cao, Kaiyi; Zhu, Jun; Qiu, Shang; Chao, Minghao; Su, Tianyu; Zhu, Xu; Guo, Kaijin; Gao, Fenglei; Yu, Dehong; Pan, Bin ·
FAERS database analysis identified distinct safety profiles for each of the four marketed gepants, with both expected and potentially novel adverse event signals detected.
Chen, Hui; Li, Yan ·
Lifestyle interventions ranked highest for preventing recurrent weight gain; semaglutide supports sustained loss during treatment but weight regain occurs after discontinuation; bariatric surgery provides the largest initial loss.
Chen, Huixian; Guo, Xiaojing; Long, Tianxue; Li, Mingzi ·
Network meta-analysis identifies agent- and dose-specific intestinal obstruction risks for GLP-1 RAs and SGLT2 inhibitors, clarifying safety profiles for clinical decision-making.
Chen, Jiann-Jy; Hsu, Chih-Wei; Hung, Chao-Ming; Suen, Mein-Woei; Wang, Hung-Yu; Yang, Wei-Chieh; Stubbs, Brendon; Chen, Yen-Wen; Chen, Tien-Yu; Lei, Wei-Te; Carvalho, Andre F; Hsu, Shih-Pin; Shiue, Yow-Ling; Zeng, Bing-Yan; Li, Cheng-Ta; Su, Kuan-Pin; Liang, Chih-Sung; Zeng, Bing-Syuan; Tseng, Ping-Tao ·
Novel ACE-inhibitory peptides were identified from Pelodiscus sinensis bone collagen through computational screening and molecular docking, showing potential as natural antihypertensive agents.
Chen, Jiaxin; Xie, Ruoyu; Mei, Yimeng; Chen, Wenxuan; Hu, Jun; Liu, Haoyu; Du, Hongying; Hao, Guijie; Ji, Xiaolong; Li, Shuangxi; Zhang, Jin ·
Compound 6, designed through rational CADD approaches, showed a unique GLP-1R binding mode and robust efficacy in both in vitro and in vivo models as a small molecule agonist.
Chen, Jiayu; Yao, Yuanshan; Li, Hao ·
Vagal sensory neurons synapse with PNECs and detect endotoxins via TRPA1, forming a neural circuit that regulates lung inflammatory responses — a previously unknown brain-lung immune axis.
Chen, Jie; Xie, Shitao; Lin, Zhekai; Zhao, Caiqi; Tao, Rujia; Ma, Yingying; Chen, Xiaoyan; Wu, Renlan; Han, Qingjian; Sui, Pengfei; Wang, Sheng; Ji, Hongbin; Song, Hai; Zhang, Xiaoming; Sun, Yangang; Song, Yuanlin; Su, Xiao ·
The IGL-Gel/HAp/NSC composite scaffold promoted neural stem cell survival, differentiation, and spinal cord tissue regeneration in SCI treatment.
Chen, Jing; Zhou, Haihua; Wang, Peng; Yang, Minyan ·