Browse more peptide research, methods and limitations.
GLP-1 RAs post-bariatric surgery promoted additional weight loss and improved metabolic markers including BMI, cholesterol, triglycerides, fasting glucose, blood pressure, and HbA1c compared to placebo.
Bilal, Abdur Rafay; Ibrahim, Muhammad; Arfin, S M Washaqul; Bilal, Abdur Raheem; Balach, Rahul; Qureshi, Shaheer; Gaba, Hateem; Collins, Peter; Ahmed, Raheel; Waqas, Saad Ahmed ·
GelMA hydrogels combining antimicrobial peptide TetraF2W-RR with photosensitizer Chlorin e6 showed enhanced antibiofilm activity via photodynamic therapy, with immobilization strategy affecting efficacy.
Bilgiç, Eda; Çelebi, Nisa Nilsu; Avşar, Nermin Topaloğlu; Karaman, Didem Şen; Pulat, Günnur ·
A dual-functional β-TCP injectable bone graft functionalized with osteogenic and antimicrobial peptides enhanced bone formation while providing broad-spectrum biofilm inhibition.
Bilgiç, Eda; Özkaya, Şevval; Gençer, Duygu; Karaman, Ozan; Pulat, Günnur ·
GLP-1 RAs demonstrated anti-inflammatory effects in patients with immune-mediated inflammatory disorders, though significant heterogeneity prevented meta-analysis.
Birda, Chhagan L; Ibrahim, Fadwa; Chatterjee, Abhirup; Jena, Anuraag; Sharma, Vishal; Sebastian, Shaji ·
Meta-analysis of rodent studies confirms collagen peptide administration consistently alleviates obesity and related symptoms in high-caloric diet-fed animals.
Bischof, Kevin; Moitzi, Anna Maria; König, Daniel ·
Tirzepatide (10 nmol/kg/day for 4 weeks) reversed brown adipose tissue whitening, reduced inflammation, and restored mitochondrial function in ovariectomized obese diabetic mice.
Bittencourt, Julie Oliveira A; Marcondes-de-Castro, Ilitch A; Marinho, Thatiany Souza; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos Alberto ·
GLP-1 agonist-induced weight loss likely mobilized adipose-stored amiodarone, causing delayed-onset amiodarone-induced thyrotoxicosis 14 months after drug discontinuation.
Black, Meghan L; Coyle, Catherine G; Bernet, Victor J; McLeod, Christopher J; Chindris, Ana-Maria ·
Mean total radioactivity recovery was 92.4% after a single 50 mg oral dose of [14C]-ubrogepant, with the drug undergoing extensive hepatic metabolism.
Boinpally, Ramesh R; Rowe, Joshua; Chandrasekar, Pushpa; White, Rebecca B; Marcantonio, Eugene E; Trainor, Nicole; Liang, Yuexia; Maciolek, Cheri; Small, James H; Houle, Robert; Hafey, Michael J; Xie, Huizhi; Yabut, Jocelyn; Fandozzi, Christine ·
Subcutaneous semaglutide combined with metformin produced significant weight loss and improved fertility outcomes in 20 consecutive PCOS patients with obesity and prediabetes.
Bolek, Tomáš; Turňová, Petra; Janošova, Svetlana; Péč, Martin Jozef; Ságová, Ivana; Nagy, Norbert; Jurica, Jakub; Mokáň, Marián; Samoš, Matej ·
Phage display-derived neutralizing AMPs (nAMPs) effectively inhibited biofilm formation by C. albicans, C. auris, and C. parapsilosis through modulation of pathogenic behavior rather than cell killing.
Bolotnikov, Grigory; Gruber, Daniel; Walter, Jan-Christoph; Kühnel, Kim; Kemal, Turgay; Rodriguez, Armando; Preising, Nico; Ständker, Ludger; Firacative, Carolina; Spellerberg, Barbara; Stenger, Steffen; Rosenau, Frank; Kissmann, Ann-Kathrin ·
Liraglutide, semaglutide, and tirzepatide all demonstrate significant efficacy for weight reduction in non-diabetic obesity, with additional cardiometabolic benefits beyond glycemic control.
Bonga, Krishna Nikhila; Padhan, Milan ·
GLP-1 RA use was associated with reduced 1-year mortality following first diabetic foot ulcer in a nationwide French cohort, with secondary analysis also examining mortality after major lower-limb amputation.
Bonnet, Jean-Baptiste; Huguet, Helena; Avignon, Antoine; Duflos, Claire; Sultan, Ariane ·
Genome-wide analysis identified poplar CLE peptides that promote ectomycorrhizal symbiosis, revealing plant small secreted peptide roles in tree-fungus association.
Bonnot, Clémence; Morin, Emmanuelle; Da Silva Machado, Emilie; Veneault-Fourrey, Claire; Kohler, Annegret; Martin, Francis ·
Systemic inflammation in HFpEF is linked to cardiovascular-kidney-metabolic conditions, while HFrEF inflammation develops secondary to cardiac stress, with distinct patterns across the ejection fraction spectrum.
Borlaug, Barry A; Holse, Cecilie; Jung, Mette Holme; Lincoff, A Michael; Mulvagh, Sharon L; Stærk-Østergaard, Jacob; Tuttle, Katherine R; Petrie, Mark C ·
GIP receptor signaling modulates PYY-induced appetite suppression and reduces associated nausea and malaise in rodents, suggesting a mechanism for improved tolerability in multi-agonist obesity drugs.
Borner, Tito; Pataro, Allison M; Curtis, Genevieve R; Alonso, Brandon; Hu, Jiayin; Fortin, Samantha M; Koul-Tiwari, Richa; Hughes, Emily; Kong, Jimmy X; Jordan, Emily; Barnes, Robert; Bernardo, Barbara; Gardner, Maxwell; Ma, Wenzhe; Gosset, James R; Esquejo, Ryan M; Fortin, Jean-Philippe; De Jonghe, Bart C; Bence, Kendra K; Hayes, Matthew R ·
Plant- and microalgae-based biotechnological platforms offer affordable production and non-invasive (oral) delivery strategies for antidiabetic peptides including insulin and GLP-1 RAs.
Boscart, Thibault; Barras, Alexandre; Plaisance, Valérie; Pawlowski, Valérie; Giovanelli, Emerson; Bardor, Muriel; D'Hulst, Christophe; Abderrahmani, Amar ·
A cystine-containing cationic lipopeptide injectable hydrogel demonstrated broad antimicrobial activity against MDR strains and effective anti-biofilm activity against MRSA.
Bose, Supratim; Poddar, Neha; Sharma, Swrajit Nath; Deb, Swapnendu; Mondal, Tanushree; Banerjee, Arindam ·
The trigeminal system may contribute to pancreatic innervation via CGRP and substance P neuropeptides, potentially influencing pancreatic blood flow, inflammation, and endocrine function.
Bou Malhab, Fady M; Jabbour, Serge A; Defronzo, Ralph; Nemr, Rita ·
AI approaches including predictive models and de novo generative design are accelerating antimicrobial and antimicrobial peptide discovery, offering a transformative response to the global resistance crisis.
Boudza, Romaisaa; Bounou, Salim; Segura-Garcia, Jaume; Moukadiri, Ismail; Maicas, Sergi ·
Transformer-based models successfully classified antimicrobial peptides using conformational dynamics as input features, treating molecular motion sequences as a language for machine learning.
Bouvier, Benjamin ·
GLP-1 RA initiators showed higher treatment persistence compared to SGLT2i initiators among Medicare Advantage beneficiaries with T2DM, including subgroups with cardiovascular disease and obesity.
Bowe, Andy; Hayes, Mary; John, Isha; Diaz, Monica; Dixon, Suzanne; Poonawalla, Insiya ·
The Sim-Q questionnaire demonstrated valid psychometric properties for measuring perceived treatment simplicity in type 2 diabetes patients across 8 US clinical sites.
Boye, Kristina S; Cutts, Katelyn N; Coyne, Karin S; Matza, Louis S ·
Three cycles of 177Lu-DOTATATE PRRT for small intestine neuroendocrine tumor led to recurrent GI bleeding requiring four ICU admissions, 14 packed cell transfusions, and eventual surgery.
Brackenier, C; Leupe, H; Dekervel, J; Verslype, C; De Hertogh, G; Topal, H; Rasschaert, G; Deroose, C M; Van Herpe, F ·
Panniculectomy outcomes and perioperative lab values were compared between patients with prior GLP-1 RA use and those with prior bariatric surgery using the TriNetX global network.
Braud, Savannah C; Terry, Peyton; Azoury, Said ·
Semaglutide treatment preserved fat-free mass and energy expenditure compared to diet restriction alone in obese minipigs, demonstrating more favorable body composition changes.
Bredum, Simon Krogh; Jacobsen, Julie M; Halling, Jens Frey; Blom, Ida; Lewis, Christopher T A; Ochala, Julien; Fredholm, Merete; Lundh, Sofia; Schmücker, Malte; Ozenne, Brice; Domingos, Ana I; Hald, Bjørn Olav; Larsen, Steen; Cirera, Susanna; Christoffersen, Berit Oestergaard ·
Retatrutide reduced body weight by 31% and showed multiple metabolic benefits including reduced fat mass, food intake, and liver disease markers in obese MASH mouse and hamster models.
Briand, François; Le Cudennec, Camille; Grasset, Estelle; Breyner, Natalia; Bigot, Claire; Dillard, Pierre; Sulpice, Thierry ·
Calcium-binding protein expression (PV, CB, CR) alone cannot reliably identify and classify GABAergic neuron subclasses in macaque cortex due to extensive co-expression patterns.
Brigande, Alev M; Krueger, Juliane; Park, Connor; Disney, Anita A ·
Three-year comparison of bariatric surgery versus GLP-1 RAs in Medicare and Medicaid patients with diabetes provides real-world effectiveness data in a publicly insured population.
Brown, Avery; Patel, Suhani S; Li, Elizabeth; Vu, Alexander Hien; Somoza, Eduardo; Chen, Jialin; Zhang, Donglan; Massie, Allan B; Orandi, Babak J; Segev, Dorry; Parikh, Manish; Chhabra, Karan ·
Comparative evaluation identified design differences and usability risks between a proposed generic GLP-1 pen injector and the reference listed drug device that could affect safe substitution.
Brunet-Manquat, Laurie; Combedazou, Anne; Ramus, Claire; Frolet, Cécile ·
VTX3232 NLRP3 inhibition reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice by tempering metabolic inflammation.
Bultinck, Jennyfer; Yuan, Shendong; Cantuti-Castelvetri, Ludovico; Brosens, Lander; Bracke, Debby; Collins, James; Goethals, Jens; Christianson, Christina; Nuss, John; Ogilvie, Kathleen ·
S protein coordinates cell wall modification and repair in Streptococcus to resist host-derived antimicrobial peptides, revealing a key bacterial defense mechanism against innate immunity.
Burnier, Jessica; Gallay, Clement; Bruce, Kevin E; Bjånes, Elisabet; Martin, Louise; Jim, Kin Ki; Tsui, Ho-Ching Tiffany; Cremers, Amelieke J H; Mignolet, Johann; Vollmer, Daniela; Biboy, Jacob; Nizet, Victor; Vollmer, Waldemar; Winkler, Malcolm E; Veening, Jan-Willem ·
Switching from semaglutide to tirzepatide precipitated lithium toxicity in a patient with schizoaffective disorder, demonstrating clinically significant pharmacokinetic interactions with GLP-1 RAs.
Burson, Jesse R; Leung, Jonathan G ·
Real-world data from a large US healthcare plan demonstrates treatment persistence patterns and patient satisfaction with self-injectable anti-CGRP monoclonal antibodies for migraine prevention.
Buse, Dawn C; Lipton, Richard B; Urman, Robert; Vaidya, Shruti J; Robinson, Sarah C; Jacobson, Alice S; Scott, Alexandra B; Bensink, Mark E; Pressman, Alice R ·
AAV9-derived peptides (AAV.PHP.eB, AAV.X1, AAV.CPP.16) grafted onto nanoparticles synergized with electroporation to enhance BBB transport beyond either approach alone.
Butkovich, Nina; Xu, Yifei; Song, Yuchen; Wang, Lu; Ramirez, Aaron; Li, Enya; Siao, Nikhil Tien Chi; Velazquez-Rivera, Eric; Xiang, Liangzhong; Xu, Xiangmin; Wang, Szu-Wen ·
Synthetic biology and bioengineering approaches are advancing the ability to modify non-ribosomal peptide synthetases for production of novel antimicrobial peptides with pharmaceutical potential.
Butler, Lucy; Awan, Ali Raza; Ellis, Tom; Akram, Muhammad Safwan ·
Physical activity promotes gut structural adaptation, enhanced nutrient sensing, and increased sensitivity to appetite-regulating gut peptides in mice.
Bæch-Laursen, Cecilie; Ucin, Jon Vergara; Galsgaard, Katrine Douglas; Llana, Jesus; Kissow, Hannelouise; Rehfeld, Jens Frederik; Holst, Jens Juul; Pedersen, Bente Klarlund; Sanchis, Paula ·
AMPs exhibit dual roles in cervical carcinogenesis — both anti-tumorigenic and pro-tumorigenic effects — requiring careful characterization before therapeutic development.
Błażejczyk, Idalia; Daniluk, Tamara; Toczyłowski, Kacper; Gorbacz-Konończuk, Joanna; Wnorowska, Urszula; Bucki, Robert; Piktel, Ewelina ·
Spatiotemporal characterization revealed distinct ghrelin and CCK distribution patterns along the juvenile seabream GIT, with levels responding to feeding status and diet composition.
Caderno, Anyell; Tang, Patrik; de Las Heras, Verónica; Gharbi, Naouel; Alarcón-López, Francisco Javier; Mancera, Juan Miguel; Martos-Sitcha, Juan Antonio; Gilannejad, Neda ·
A machine learning-enabled venom peptide platform rapidly identifies and optimizes disulfide-stabilized venom peptides targeting GPCRs and ion channels for pharmaceutical development.
Cai, Fei; Zhou, Lijuan; Delgado, Bryce; Chang, Wenping; Tom, Jeffrey; Hernandez, Evelyn; Joshi, Prajakta; Song, Aimin; Masureel, Matthieu; Maun, Henry R; Chang, Andrew; Zhang, Yingnan ·
GLP-1 RA initiation was associated with reduced incidence of alcohol, cannabis, cocaine, nicotine, opioid, and other SUDs in veterans without prior addictions, and reduced adverse outcomes in those with pre-existing SUDs.
Cai, Miao; Choi, Taeyoung; Xie, Yan; Al-Aly, Ziyad ·
Insulin therapy perceptions differ significantly between type 1, type 2, and prediabetic patients, with negative perceptions common across groups and potentially delaying treatment.
Cakir, Ahmet; Memis, Hasan; Ozdemir-Ayduran, Nesligül; Tarin, Serenay; Evren, Bahri ·
An AI pipeline integrating BioBERT-based text mining and molecular dynamics simulation identified natural compound candidates as potential GLP-1 receptor agonists.
Cakmak, Rabia Kalkan; Besli, Nail; Ercin, Nilufer; Celik, Ulkan ·
Comprehensive meta-analysis of RCTs and propensity-matched cohorts demonstrates GLP-1 RA efficacy in obese HFpEF patients, with benefits including weight loss and anti-inflammatory effects.
Caldeira Gaelzer, Giulia; Armani Prata, Alonzo; Gustavo Rizzolli, Luís; Mendes Afonso, Luisalice; Lenci Marques, Gustavo ·
Vitamin D modulates infectious disease outcomes through antimicrobial peptide induction (cathelicidin/LL-37), immune regulation, and anti-inflammatory effects in COVID-19, Long COVID, and influenza.
Caliman-Sturdza, Olga Adriana; Gheorghita, Roxana Elena; Soldanescu, Iuliana; Dimian, Mihai; Mangul, Serghei ·
NPY inhibits vagal activation of NTS catecholamine neurons via presynaptic Y2 receptors, providing a mechanism by which NPY modulates gut-derived satiety signaling in the brainstem.
Calkins, Rowan J; Zhao, Huan; Page, Stephen J; Neyens, Drew M; Appleyard, Suzanne M ·
GLP-1 analogues were not associated with increased recurrent pancreatitis risk in diabetic patients with prior pancreatitis or elevated lipase, in a cohort of >4.5 million members.
Calvarysky, Bronya; Gal, Yaara; Kushnir, Shiri; Turjeman, Adi; Shochat, Tzippy; Dotan, Idit; Diker Cohen, Talia ·
Bacteriocins offer a highly specific, sustainable alternative to chemical pesticides for controlling multi-resistant phytopathogenic bacteria in agriculture.
Caly-Simbou, Eva; Ramin-Mangata, Stéphane; Poussier, Stéphane; Pecrix, Yann ·
EDKA occurred in a patient on tirzepatide monotherapy without concurrent SGLT-2 inhibitor use, suggesting GLP-1/GIP agonists may independently precipitate this rare condition.
Campana, Christina; Heaney, Ashley; Ceraolo, Negin; Srinivas, Surbhi; Simon, Erin L ·
Congenital isolated GH-deficient individuals show severely reduced IGF-I and IGFBP-3 but altered IGF-I bioavailability, associated with no premature atherosclerosis and normal lifespan despite metabolic risk factors.
Campos, Viviane C; Aguiar Oliveira, Manuel H; Bidlingmaier, Martin; Yuen, Kevin C J; Salvatori, Roberto; Oliveira, Carla R P; Leal, Angela; Melo, Enaldo; Schilbach, Katharina; Frystyk, Jan; Schweizer, Júnia R O L ·
GLP1R polymorphisms rs6923761 and rs761387 significantly influenced clinical response to oral semaglutide in a retrospective cohort of T2DM patients.
Candido, Riccardo; Toffoli, Barbara; Baccichetto, Gabriele; Marchese, Francesca; Carpenè, Silvia; Gaiotti, Sara; Fabris, Bruno; Bernardi, Stella ·