Browse more peptide research, methods and limitations.
Peptide cancer vaccines combined with immune checkpoint inhibitors show enhanced anti-tumor responses, representing a promising personalized oncology approach.
Banday, Abid H; Manzoor, Meer Mehru; Nissar, Urooj; Jaleel, Seeham ·
Combined GLP-1 RA/SGLT2i therapy produced rapid weight loss, menstrual normalization, and spontaneous conception within 7 months in two obese women with PCOS and T2D.
Banerjee, Mainak; Dasgupta, Sujoy ·
GLP-1 RAs and pioglitazone showed the greatest histological improvement in MASH, with weight loss mediating a significant portion of fibrosis benefit.
Banerjee, Mainak; Pal, Rimesh; Pal, Sandip ·
Uperin 3.5 undergoes rapid α-helix to β-sheet conformational switching near zwitterionic micelle surfaces within microsecond timescales, driven by membrane-peptide interactions.
Banerjee, Sucharita; Prasad, Anup Kumar; Martin, Lisandra L; Panwar, Ajay Singh ·
Perioperative GLP-1 receptor agonist use was associated with comparable or improved outcomes following midfoot arthrodesis in propensity-matched patients.
Bank, Nicholas C; Lauck, Bradley J; Dalola, Joseph; Duggan, Sam; Dyke, William B; Lalli, Trapper A ·
Rectal bile acid exposure stimulates INSL5 secretion in humans, and circulating INSL5 levels are elevated and associated with diarrhea severity in bile acid diarrhea patients.
Bannon, Christopher A; Walters, Julian R F; Wu, Tongzhi; Kay, Richard G; Punnoose, Austin; Spiller, Robin C; Wilson, Jonathan; Verdino, Petra; Barker, Peter; Burling, Keith; Horowitz, Michael; Rayner, Christopher K; Ford, Alexander C; Reimann, Frank; Gribble, Fiona M ·
Inhaled antibiotic and biologic formulations can achieve higher concentrations at the lung epithelial lining fluid, overcoming Pseudomonas resistance mechanisms including biofilm formation and efflux pumps.
Baral, Prodip Kumar; Dummer, Jack; Pletzer, Daniel; Das, Shyamal C ·
Across all BMI classes, metabolic bariatric surgery produced the greatest weight loss, but newer obesity medications including tirzepatide significantly narrowed the efficacy gap compared to surgical interventions.
Barazzoni, Rocco; Monami, Matteo; Buscemi, Silvio; Busetto, Luca; De Luca, Maurizio; Navarra, Giuseppe; Ragghianti, Benedetta; Silverii, Giovanni Antonio; Belluzzi, Amanda; Mannucci, Edoardo; Sbraccia, Paolo ·
Prior mycobacterial exposure of airway epithelial cells reduced intracellular infection efficiency of M. tuberculosis and M. avium during subsequent exposure and dampened cytokine responses.
Barclay, Amy M; Ninaber, Dennis K; Walburg, Kimberley V; Hiemstra, Pieter S; Ottenhoff, Tom H M; van der Does, Anne M; Joosten, Simone A ·
Discontinuation of incretin-based obesity medications results in weight regain and reversal of cardiometabolic improvements, with up to 50% of patients stopping treatment within 1-2 years.
Barenbaum, Sarah R; Aras, Mohini; Kashyap, Sangeeta; Aronne, Louis J ·
Incretin-based therapy use in type 2 diabetes patients was associated with reduced Parkinson's disease incidence in both a retrospective cohort analysis and meta-analysis of available evidence.
Barer, Yael; Ast, Tal; Chodick, Gabriel; Twig, Gilad; Giladi, Nir ·
Semaglutide, dulaglutide, liraglutide, and exenatide showed comparable risks of sight-threatening diabetic retinopathy complications in a large target trial emulation study.
Barkmeier, Andrew J; Deng, Yihong; Swarna, Kavya Sindhu; Herrin, Jeph; Polley, Eric C; Umpierrez, Guillermo E; Galindo, Rodolfo J; Ross, Joseph S; Mickelson, Mindy M; McCoy, Rozalina G ·
Type 2 diabetes patients on GLP-1 receptor agonists had a statistically significant 33.9% higher relative risk of NAION over five years (risk ratio 1.339, 95% CI 1.137-1.577, p=0.005), though the absolute risk difference was only 0.022%.
Barnett, Maxim J; Ibe, Festus; Lam, Justin ·
A novel deep learning-based 3D whole-heart fibrosis quantification pipeline demonstrated that semaglutide significantly reduces myocardial fibrosis in a HFpEF preclinical model.
Barrado-Ballestero, Sheyla; Yttergren, Sarah Torp; Hahn, Max; Rosenkilde, Marie Biviano; Jensen, Ditte Marie; Christensen, Michael; Thisted, Louise; Holmberg, Heidi Lindgreen; Teixeira, Geoffrey; Biering-Sørensen, Tor; Salinas, Casper Gravesen; Roostalu, Urmas ·
Tirzepatide at 2.5 mg and 5.0 mg produced significant short-term weight loss and metabolic improvements in a real-world outpatient obesity population, confirming clinical trial benefits translate to routine practice.
Barrea, Luigi; Verde, Ludovica; Galasso, Martina; Patrone, Renato; Digitale, Lucia; Limardi, Alessandro; Orio, Marcello; Ragozzino, Giovanni; Digitale, Luigi; Salvatore, Vittorio; Savoia, Antonella; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna ·
P. gingivalis infection may dysregulate and weaken innate immunity by degrading antimicrobial peptides (LL-37), Apolipoprotein E, interferons, and TNF-α, potentially enabling Alzheimer's disease pathology.
Barron, Annelise E; Lin, Jennifer S; Ryder, Mark I; Bergman, Peter ·
Peptide-based metabolic regulators — particularly multi-receptor agonists targeting GLP-1, GIP, and glucagon receptors — have emerged as the most effective pharmacological class for obesity and T2DM treatment.
Barzgar, Haniyeh; Darmadi, Darmadi; Nafisa, Jabbarova; Narkulov, Suxrob; Sviridova, Maria B ·
Dulaglutide (0.2 mg/kg/day) for six weeks ameliorated L-NAME-induced hypertensive kidney damage through PPAR-gamma activation and VEGF restoration, improving renal function and reducing inflammation.
Bastawy, Nermeen; El-Mosallamy, Aliaa E M K; Rasheed, Rabab Ahmed; Sadek, A S; Khattab, R T; Ali, Esraa; Zaghloul, Randa A; Ghaly, Wael B A; Boushra, Amy F ·
Plasma GLP-1, GIP, and TMAO levels showed associations with coronary artery disease severity as measured by Gensini scores in patients undergoing angiography for exertional angina.
Batirel, Saime; Cetinkaya, Bengu; Sahin, Ali; Alakbarova, Nodira; Guctekin, Tuba; Ozben, Beste; Tigen, Mustafa Kürşat ·
Weekly subcutaneous VK2735 produced significant dose-dependent weight reduction over 13 weeks, with active treatment groups showing meaningful weight loss compared to placebo.
Bays, Harold E; Toth, Phillip; Alkhouri, Naim; Pullman, John; Freilich, Bradley; Neutel, Joel; Ji, Summer; Stubbe, Scott; Hedges, Parke; Lian, Brian ·
O-POSSUM scores and BNP levels showed predictive value for ICU admission in geriatric hip fracture patients with heart failure, with ICU admission rates differing across HFpEF, HFmrEF, and HFrEF subtypes.
Bayındır, Serpil; Kazez, Muhammed; Yalın, Mustafa ·
Adding the cell-penetrating peptide SynB1 to the ELP-P10 anti-CMV peptide construct enhanced intracellular delivery and antiviral potency at lower concentrations.
Beeton, Komal; Haskell, Jacob P; Mitra, Dipanwita; Taylor, Erin B; Bidwell, Gene L ·
Antimicrobial peptides are dysregulated in glial and neuronal tissues across multiple neurodegenerative diseases, contributing to neuroinflammation, mitochondrial dysfunction, and neuronal loss through Toll and IMD immune pathway overactivation.
Behera, Priyatama; Rangappa, Nagaraj; Chandrashekar, Madhura; Mishra, Amit; Chinnathambi, Subashchandrabose; Mishra, Monalisa ·
GLP-1 RAs showed no significant effect on cardiovascular mortality or worsening heart failure events in HFpEF patients but were associated with improved quality of life and favorable safety data across 6 RCTs with 5,564 participants.
Behers, Benjamin J; Sanchez, Christian; Hozayen, Omar; Hozayen, Yousef; Kammer, Rheiner; Corrigan, William T; Stephenson-Moe, Christoph A; Miller, Matthew W; Idriss, Mohab; Cekan, Luis E; King, Alan D; Brown, Garrett H; Hamad, Karen M ·
Glucagon receptor agonism increases lipid oxidation, substrate mobilization, and energy expenditure, complementing GLP-1R appetite suppression and potentially overcoming adaptive metabolic decline during weight loss.
Beji, Sarra; Caron, Alexandre ·
Refractory meningioma with lung metastases showed high somatostatin receptor expression on 68Ga-DOTATOC PET/CT, enabling successful targeted treatment with 177Lu-DOTATATE peptide receptor radionuclide therapy.
Bekkhoucha, Adam; Agrigoroaie, Laurentiu; Deandreis, Desiree; Guyon, David; Chehade, Feras ·
Weight loss remains the only disease-modifying therapy for IIH, with GLP-1 RAs offering a promising pharmacologic approach, though all current treatments are limited by side effects, poor long-term efficacy, or restricted applicability.
Belanger, Katherine; Ashraf, Omar; Rau, Jill; Hui, Ferdinand; Fargen, Kyle M ·
Network meta-analysis provides comparative efficacy rankings of GLP-1 RAs, tirzepatide, and SGLT-2 inhibitors for NAFLD/NASH treatment, enabling indirect comparisons across drug classes.
Belančić, Andrej; Antza, Christina; Poutachidis, Anastasios; Palaska, Smaro; Gkrinia, Elvira Meni Maria; Faour, Andrea Katrin; Sener, Yusuf Ziya; Sener, Seher; Sultana, Rehena ·
MALDI mass spectrometry and proteomics revealed substantial molecular diversity in antimicrobial extracts from 4 Tunisian extremophilic plant species, with activity varying by plant organ.
Ben Brahim, Raoua; Voisin, Sébastien N; Fouzai, Khaoula; Bulet, Philippe; Regaya, Imed ·
Evidence supporting the routine use of troponin, BNP, echocardiography, and outpatient cardiac monitoring in ER syncope patients is limited, with unclear benefit for 30-day outcomes.
Benabbas, Roshanak; Zehtabchi, Shahriar; Wakai, Abel; Allen, Robert; deSouza, Ian S; Richards, Rebekah J; Curley, David; Dunne, Eric; Sinert, Richard ·
OAS acts as a glucose-dependent insulin secretagogue, accumulating in the pancreas after oral administration and dose-dependently improving postprandial glycemia in lean and prediabetic mice.
Benatar, Clara; Zhang, Xufei; Haddam, Ines; Ribes, Sandy; Bobet, Sophie; Monnoye, Magali; Lamy, Elodie; Grassin-Delyle, Stanislas; Juillard, Vincent; Layec, Séverine; Delorme, Christine; Douard, Véronique ·
Neoadjuvant GLP-1RA use (8.5% of patients) did not significantly affect post-surgical weight loss outcomes after sleeve gastrectomy or Roux-en-Y gastric bypass.
Benavidez, Maria Charina; Redpath, Sophia; Trautmann, Stephanie; Ceron, Santiago; Schimpke, Scott; Myers, Jonathan; Omotosho, Philip; Torquati, Alfonso; Skertich, Nicholas J ·
Bicycle drug conjugates represent a novel peptide-based approach to targeting EphA2 in solid tumors, potentially overcoming the efficacy and safety limitations of previous EphA2-targeting agents.
Bennett, Gavin; Riedl, Jitka; Mudd, Gemma ·
Gb-piscidin, a novel 22-residue class 1 piscidin from gilthead seabream, exhibits broad antimicrobial activity and immunostimulatory potential, with a Cys9-Cys16 disulfide bridge critical for function.
Berenjkar, Najmeh; Kalbassi, Mohammad Reza; Hosseinkhani, Saman; Beemelmanns, Christine; Moghaddam, Jamshid Amiri ·
A comprehensive and replicable protocol for isolation, biochemical characterization, and quantitative cellular uptake analysis of CPP-fusion proteins and supercharged proteins was developed and validated.
Beribisky, Alexander V; Sarne, Victoria; Huber, Anna; Hengstschläger, Markus; Laccone, Franco; Steinkellner, Hannes ·
Network meta-analysis of RCTs indicates tirzepatide (dual GIP/GLP-1 agonist) provides greater body weight reduction and glycemic improvement compared to semaglutide (GLP-1 agonist alone) in obesity.
Bernardi, Julia C; Cavalcante, Deivyd V S; Huntermann, Ramon; Molinari, Maria E; Zanon, Luana Z; Khater, Jacinthe; Gomez, Victor A; Fischer-Bacca, Caroline O ·
LEAP2 reduces blood pressure in both normal and hypertensive rats and modulates β-adrenergic cardiac responses, acting through GHSR antagonism and inverse agonism.
Berrio, Sixta Isabel Atencio; Carvalho, Jhulle Horrane; Dutra, João Batista; Eliezeck, Marcos; Scalzo, Sergio; Ribeiro, Juliana Vila Verde; Mendonça, Michelle Mendanha; Gomes, Rodrigo Mello; Pedrino, Gustavo Rodrigues; Colombari, Eduardo; Castrogiovanni, Daniel; Milagros, Sisti Maria; Racioppi, Maria Florencia; Petroff, Martin Vila; Cantel, Sonia; Fehrentz, Jean-Alain; Guatimosim, Silvia; Perelló, Mario; de Castro, Carlos Henrique; Xavier, Carlos Henrique ·
A Clarias gariepinus PACAP-38 analog enhanced immune homeostasis and defense against V. parahaemolyticus in L. vannamei shrimp, demonstrating cross-species antimicrobial peptide applications.
Betancourt, Jesús Luis; Ihedimbu, Ijeoma; Rodríguez-Ramos, Tania; Coronado-Molina, Daniel Eduardo; Carpio, Yamila; Estrada, Mario Pablo; Hernández-López, Jorge; Ramos, Laida; Dixon, Brian ·
GLP-1 receptor agonists achieve transformative obesity treatment through dual peripheral (metabolic, GI) and central (appetite, reward) mechanisms along the gut-brain axis.
Beutler, Lisa R ·
CMR-derived right ventricular parameters (RVEF, RVESVi, RVMi, VMI) and septal curvature were associated with clinical outcomes in 36 children with pulmonary arterial hypertension.
Beyazal, Meryem; Keceli, Merter; Dogan, Oguzhan; Ece, Ibrahim ·
Real-world comparison of GLP-1 RAs versus SGLT-2 inhibitors in MASH patients evaluated cirrhosis incidence, hepatocellular carcinoma rates, and liver enzyme profile changes.
Beyene, Elizabeth; Chirumamilla, Lakshmi; Bisrat, Mekdem; Bowen, Allan; Fetle, Yonas; Wilkerson, Brandon; Wudeneh, Addishiwot; Gillani, Syed Fahad; Larbi, Daniel; Michael, Miriam ·
Marine-derived peptides L3 and L3-K cause extensive proteome remodeling (175 and 120 differentially expressed proteins) and disrupt gene expression at the DNA level rather than acting through membrane lysis.
Beyer, Luisa I; Thoma, Johannes; Acha Alarcon, Leonarda; Unksov, Ivan N; Karlsson, Roger; Inda-Díaz, Juan S; Tietze, Alesia A ·
Molecular dynamics simulations show caryophyllene and copaene bind to Aβ1-42 and disrupt aggregation-prone conformations in the C-terminal and central hydrophobic domains.
Bezerra, Iverson Conrado; Viana, Jéssika de Oliveira; Bisneto, Jocelin Santa Rita; Cavalcante, Gabriel Gomes; Barbosa de Luna, João Gabriel; da Silva, Artur José; Weber, Karen Cacilda; Machado, Giovanna; de Lima Filho, José Luiz; Gubert, Priscila ·
Antimicrobial peptides isolated from probiotic bacteria demonstrate activity against Salmonella, representing a viable alternative to conventional antibiotics for poultry food safety.
Bhandari, Menuka; Lokesh, Dhanashree; Thenissery, Anusree; Shrestha, Rajeev; Rajashekara, Gireesh ·
The CHAMP assay (Chloroalkane HaloTag Azide-based Membrane Penetration) accurately reports cytosolic accumulation in high throughput, distinguishing true cytosolic delivery from membrane association or endosomal trapping.
Bhandari, Sobika; Ongwae, George M; Dash, Rachita; Liu, Zichen; Chordia, Mahendra D; He, Yuchen; Pires, Marcos M ·
Laminin-derived bioactive peptide hydrogels with tunable self-assembly properties can direct cellular responses through engineered biochemical cues mimicking the ECM.
Bhandary, Ranit; Sen, Sourav; Mohanty, Sweta; Roy, Sangita ·
AMPs are expressed in the CNS at basal levels, upregulated in neurological disorders, and play multifunctional roles in neuroinflammation including immune modulation and neuroprotection beyond antimicrobial activity.
Bhusal, Anup; Lee, Won-Ha; Suk, Kyoungho ·
FxCy2, a novel AMP from Lactobacillus paracasei FX-6, inhibited H. pylori (MIC = 1.25 mg/mL) and demonstrated synergistic antibacterial effects with clinical antibiotics.
Bi, Bo; Kang, Meng; Lin, Qianru; Wang, Qun; Li, Xiaoqing; Ye, Zhuming; Ho, Chi-Tang; Cao, Yong ·
GFOGER peptide functionalization of PLGA/HA electrospun scaffolds enhanced BMSC adhesion and osteogenic commitment through integrin α2β1-mediated signaling.
Bi, Ming; Liu, Xiaoli; Zhang, Chunyu; Wang, Xiaoyun; Li, Jiahui; Dong, Yuanjun; Mao, Jifu; Hu, Xingyou; Han, Hui; Wang, Yongliang ·
Semaglutide prescribed at hospital discharge after acute coronary syndrome in T2DM patients was feasible in real-world practice, providing exploratory data on early post-ACS GLP-1 RA initiation.
Biasin, Marco; Stratinaki, Maria; Cordioli, Nicolò; Armani, Ilaria; De Giovanni, Sara; Aletras, George; Betta, Davide; Callegarin, Luca; Gambaro, Alessia; Morani, Giovanni ·