Browse more peptide research, methods and limitations.
Serum concentration modulates TNBC cell migration, and cell-penetrating peptides successfully delivered proapoptotic cargo under optimized conditions.
Araki, Yurina; Takatani-Nakase, Tomoka; Ninomiya, Sohei; Matsumoto, Mitsuyo; Hirose, Hisaaki; Kawaguchi, Yoshimasa; Fujiwara, Daisuke; Michigami, Masataka; Katoh, Hironori; Wada, Takehiko; Futaki, Shiroh; Fujii, Ikuo; Hagiwara, Masaya; Nakase, Ikuhiko ·
Multifunctional wound healing platforms integrating antimicrobial activity, tissue regeneration, immunomodulation, and real-time monitoring are emerging for personalized care.
Arciola, Carla Renata; Panichi, Veronica; Bua, Gloria; Costantini, Silvia; Bottau, Giulia; Ravaioli, Stefano; Capponi, Eleonora; Campoccia, Davide ·
SNAC absorption enhancer in oral semaglutide significantly disrupts gut microbiota and triggers systemic inflammation in rats, independent of semaglutide's effects.
Ariaee, Amin; Noueihad, Karim; Hunter, Alex; Wignall, Anthony; Wardill, Hannah R; Davies, Maya; Prestidge, Clive A; Joyce, Paul ·
Online reviews reveal that Ozempic users actively weigh weight loss benefits against GI side effects, with specific factors influencing satisfaction and continuation decisions.
Armanious, Abanoub J; Hunter, Rachel-Mae; Griffiths, Kristi R; Bowrey, Hannah E; Brown, Robyn M; James, Morgan H ·
BacA protein imports NCR antimicrobial peptides into the bacterial cytoplasm for proteolytic degradation, protecting symbiotic rhizobia during nitrogen fixation.
Arnold, Markus F F; Sankari, Siva; Deutsch, Michael; Gruber, Charley C; Guerra-Garcia, Francisco J; Beis, Konstantinos; Walker, Graham C ·
Multiple pharmacological strategies are being investigated to preserve lean mass during obesity medication-induced weight loss, addressing a critical gap in current treatment.
Arora, Gunjan; Conde, Katherine R; Desouza, Cyrus V ·
IL2Pepscan accurately predicts IL-2-inducing peptides and identifies candidates across global viral proteomes for immunotherapy applications.
Arora, Pooja; Abhigyan, Rachit; Periwal, Neha; Agrawal, Lakshay; Sood, Vikas; Kaur, Baljeet ·
Semaglutide users with overweight/obesity and multimorbidity had 27% lower total medical costs ($891 vs $1,213/month) compared to matched non-users.
Arora, Prachi; Dabbous, Firas; Udayachalerm, Sariya; Saiontz-Martinez, Cynthia; Zhao, Zhenxiang; O Hartaigh, Briain; Fabricatore, Anthony; Bassan, Matthew; Alvarez, Sara; Fitch, Angela ·
Multiple novel therapeutic approaches for resistant hypertension are advancing, including RNA-based therapies, new mineralocorticoid antagonists, and device-based interventions.
Arriola-Montenegro, Jose; Chaponan-Lavalle, Andres; Nombera-Aznaran, Natalia; Abdalla, Mohammed; Bizer, Benjamin; Mohan, Arjunmohan; Muñoz Verdugo, Irma Andrea; Zardoost, Pooya; Ordaya-Gonzales, Karina; Villarreal Rizzo, Alan; Rios-Garcia, Wagner; Yip, Laverne Kar Yin; Gonzalez Suarez, Maria L ·
The ALL has extensive innervation with proprioceptive, nociceptive, and autonomic nerve fibers, suggesting active roles in knee position sensing and pain processing.
Arviza-Lorenzo, P; Aragonés, P; Valderrama-Canales, F J; Schicht, M; Paulsen, F; Tschernig, T; Brockmeyer, M; Ruzik, K; Vázquez Osorio, M T ·
Six melanoma helper peptide vaccination induced tumor-specific antibodies with isotype distributions varying by adjuvant type.
Ashkani, Emily G; Dickinson, Anna M; Olson, Walter C; Taylor, Justin J; Slingluff, Craig L ·
A monomeric peptide combining MC4 and GLP-1 receptor agonism showed enhanced weight loss and metabolic benefits with improved tolerability in preclinical models.
Ashlaw, Emily F; Elfers, Clinton T; Chichura, Kylie S; Miranda, Isabella Chavez; McGivney, Aelish; Chepurny, Oleg G; Holz, George G; Mullins, Ginger; den Hartigh, Laura J; Liu, Yongjun; Roth, Christian L; Doyle, Robert P ·
Hybrid peptide KF-22, fusing snake and human cathelicidin fragments, demonstrated potent activity against multidrug-resistant Gram-positive and Gram-negative bacteria.
Asmamaw, Demeke; Cai, Huajun; Prateeksha, Prateeksha; Khalid, Mehwish; Mwangi, James; Yi, Wang; Lu, Quimin; Lai, Ren; Duan, Zilei ·
Non-synaptically released oxytocin acts through vasopressin V1a receptors to regulate social communication (scent marking) in hamsters.
Aspesi, Dario; Walton, James C; Grieb, Zachary A; Kirchner, Matthew K; Song, Zhimin; Long, Madeline R; Larkin, Tony E; Stern, Javier E; Albers, H Elliott ·
GLP-1 RA use was associated with reduced risk of obesity-related cancers in patients with type 2 diabetes and/or obesity across combined RCT and observational evidence.
Ateiwi, Yousef A; Mahmood, Rahil; Wong, Hon Jen; Low, Chen Ee; Yau, Chun En; Yan Bin Lee, Ainsley Ryan; Eng, Pei Chia; Lee, Matilda; Chan, Mark Y; Sia, Ching-Hui ·
Preclinical and epidemiological evidence consistently supports GLP-1 RAs as neuroprotective agents across Alzheimer's, Parkinson's, and multiple sclerosis.
Athauda, Dilan; Greig, Nigel H; Meissner, Wassilios G; Foltynie, Thomas; Gandhi, Sonia ·
Tebufenozide alters H. armigera gut immunity beyond molting disruption, inducing IMD pathway activation, AMP expression changes, and modified antiviral defense.
Attarianfar, Marzieh; Mikani, Azam; Mehrabadi, Mohammad ·
Systematic review across multiple databases found no consistent evidence of increased suicidality associated with GLP-1 receptor agonist use.
Au, Hezekiah C T; Zheng, Yang Jing; Le, Gia Han; Wong, Sabrina; Teopiz, Kayla M; Kwan, Angela T H; Rosenblat, Joshua D; Mansur, Rodrigo B; Choi, Hayun; McIntyre, Roger S ·
Personalized drug screening in patient-derived GEP-NEN cultures successfully identified individual tumor drug responses, demonstrating precision oncology feasibility.
Auernhammer, Christoph J; Wang, Katharina; Maccio, Umberto; Knösel, Thomas; Hungbauer, Maximilian P; Schilbach, Katharina; Maurer, Julian; Peischer, Lea; Reul, Astrid; Kuzmenko, Elena; Luca, Edlira; Hamati, Julia; Vetter, Diana; Oberholzer, Jose; Fritsch, Ralph; Pacak, Karel; Grossman, Ashley B; Beuschlein, Felix; Reincke, Martin; Hantel, Constanze; Zitzmann, Kathrin; Nölting, Svenja ·
Disc degeneration in a goat model triggered neuroimmune activation with increased CGRP and substance P expression in degenerated discs and adjacent tissues.
Augustin, Janai A; Burt, Kevin G; Barrett, Caitlin; Fainor, Matthew; Orozco, Brianna S; Schaer, Thomas P; Smith, Harvey E; Mauck, Robert L; Gullbrand, Sarah E ·
The GLP-1R functions as an organizer of complex signaling nanodomains involving phase separation condensates and endosomal signaling beyond canonical cAMP activation.
Austin, Gregory; Tomas, Alejandra ·
Incretin-based therapies are fundamentally changing cardiovascular outcomes in diabetes and obesity through multiple protective mechanisms supported by strong clinical trial evidence.
Avogaro, Angelo ·
Prior GLP-1 RA/GIP-RA use was associated with decreased risk of hypocalcemia following total thyroidectomy in a propensity-matched analysis.
Ayo-Ajibola, Oluwatobiloba; Jung, Tyler; Razura, Diego E; Gallagher, Tyler J; Lin, Matthew E; Angell, Trevor E; Kwon, Daniel I ·
Next-generation antihypertensives targeting novel pathways — including siRNA, endothelin antagonists, and GLP-1 RAs — show promise for improving global blood pressure control.
Azizi, Michel; Tuttle, Katherine R; Brown, Jenifer M; Piskorz, Daniel L; Kario, Kazuomi; Williams, Bryan ·
SNAP-47 mediates somatodendritic oxytocin dynamics in hypothalamic neurons, representing novel molecular machinery for non-synaptic neuropeptide release.
Aznar-Escolano, Beatriz; Royo, Maria; Madrigal, Maria Pilar; Portalés Montes, Adrián; Villanueva, José; Gutiérrez, Luis Miguel; Jurado, Sandra ·
TPA treatment reprogrammed extracellular vesicle miRNA cargo from both stem cells and sarcoma cells, shifting intercellular communication toward immune activation and tumor suppression.
B R G Ley, Michelle; Galoian, Karina; Martinez, Daniel A; Patel, Arianna; Thomas, Reanna; Parker, Tressa R; Friedman, Lee; Andryski, Allie L; Hornicek, Francis J; Best, Thomas M; Kouroupis, Dimitrios ·
FR-20 peptide loaded in self-healing hydrogel showed enhanced stability, sustained antimicrobial activity, and promoted healing in infected wound models.
Ba, Qi; Yao, Jiaxin; Tian, Hao; Meng, Yuanyuan; Kong, Yichen; Jia, Yongbo; Xu, Zhangshen; Yin, Shuhang; Gong, Wei; Wang, Yuli; Yang, Yang; Gao, Chunsheng; Yang, Meiyan ·
α-Helical stapling effectively prevents IAPP peptide aggregation and amyloid-associated cytotoxicity, with efficacy varying by stapling strategy.
Babych, Margaryta; Nguyen, Phuong Trang; Bérubé, Frédérique; Bourgault, Steve ·
Tesamorelin significantly reduces visceral and hepatic fat in HIV-associated lipodystrophy versus placebo across randomized controlled trials.
Badran, Ahmed Samy; Helal, Abdulrhman; Shata, Karim Samir; Ayesh, Hazem ·
Semaglutide significantly improved cognitive dysfunction in overweight/obese adults with major depressive disorder in a 16-week randomized clinical trial.
Badulescu, Sebastian; Gill, Hartej; Shah, Hiya; Brudner, Ryan; Phan, Lee; Di Vincenzo, Joshua D; Tabassum, Aniqa; Armanyous, Michael; Llach, Cristian-Daniel; Rosenblat, Joshua D; McIntyre, Roger S; Mansur, Rodrigo B ·
Bicyclic CPPTACs selectively degrade extracellular and cell surface proteins through CPP-induced endocytosis and lysosomal delivery.
Bai, Jinyu; Shi, Huaihuai; Chen, Jitun; Tian, Hui; Liang, Jiaxin; Chen, Bichun; Li, Jiazhong; Fang, Lijing ·
NPTX2 in peripheral sensory neurons amplifies IL-31/IL-31R-mediated chronic itch in atopic dermatitis, representing a novel therapeutic target.
Bai, Xue-Qiang; Wu, Bing-Xin; Wang, Ji-An; He, Cheng; Shen, Yong-Liang; Wei, Xiao; Zhang, Yu-Qi; Chen, Xue-Wen; Sun, Rong; Gui, Qun-Feng; Wang, Juan; Zhang, Zhi-Jun ·
Boleokidin39-61 exhibited broad-spectrum antibacterial activity including against MDR strains, with confirmed in vivo protective efficacy in fish.
Bai, Yuqi; Zhan, Jingyuan; Zhang, Weibin; Zheng, Wenbin; Chen, Fangyi; Wang, Ke-Jian ·
Pecbloodin18-37 from mudskipper showed potent antimicrobial activity against E. tarda including MDR strains, with in vivo protective efficacy.
Bai, Yuqi; Zheng, Wenbin; Zhang, Weibin; Zhan, Jingyuan; Chen, Fangyi; Wang, Ke-Jian ·
Gene fusions between TLPs and AMPs/RLKs at different evolutionary timepoints created novel defense proteins that enhance rapeseed resistance against Sclerotinia disease.
Bai, Zetao; He, Yizhou; Huang, Junyan; Zhong, Xue; Shi, Meijuan; Zuo, Rong; Tang, Minqiang; Xie, Meili; Gao, Feng; Tong, Chaobo; Liu, Lijiang; Liu, Shengyi ·
AMP-engineered watermelon vesicles in temperature-responsive hydrogel provided sequential infection control followed by wound healing promotion.
Bai, Ziyang; Zhao, Yifan; Gong, Yajuan; Du, Meijun; Zhang, Wenjun; Zhang, Ke; Zhi, Yongchao; Nie, Yanan; Li, Xia; Wu, Xiuping; Li, Bing ·
HFpEF is better understood as a systemic cardio-metabolic disorder where GLP-1 RAs and SGLT2 inhibitors show benefit by targeting underlying metabolic dysfunction rather than neurohormonal pathways.
Baidya, Debasrita; Hanumanpratap Singh Kshatri, Abhishek; Zerzan, Emi K; Menon, Gayathri J; Sawale, Mihika; Subhash Bhalodiya, Sunny ·
Second-generation non-aggregating, long-acting amylin analogues are advancing in clinical development, offering improved dosing convenience over pramlintide.
Bailey, Clifford J; Flatt, Peter R; Conlon, J Michael ·
Multiple novel diabetes therapies targeting new pathways are in development, aiming to improve glycemic control while avoiding hypoglycemia and supporting weight loss.
Bailey, Clifford J ·
SGLT2 inhibitors and GLP-1 RAs have transformed CKD management with cardiorenal benefits beyond glucose control, alongside emerging therapies targeting novel pathways.
Baker, Lyle W; Ovincy, Cene; Souvalian, Levon; Hickson, LaTonya J; Chebib, Fouad T ·
NAION in a young diabetic patient on semaglutide completely resolved after GLP-1 RA discontinuation, adding to emerging NAION-GLP-1 RA association concerns.
Bakheet, Mashair; Chaudhary, Attiqa ·
Neuropeptides such as substance P and CGRP exert dual effects on bone-remodeling cells and immune populations, directly shaping the metastatic niche that allows cancer cells to grow in bone.
Bakir, Mohamad; Dabaliz, Alhomam; Raddaoui, Mohammed; Fatash, Hala; Elsaadany, Nourhan; AlKattan, Wael; Mohammad, Khalid Said ·
Diabetes and heart failure have a bidirectional pathophysiological relationship where each condition actively promotes and worsens the other.
Balagopalan, Jayagopal Pathiyil; Bansal, Sandeep; Bhattacharyya, Arpandev; Zargar, Abdul Hamid; Dani, Sameer; Taraphder, Abhijit; Almeida, Alan; Deka, Nilakshi; Jain, Sanjay; Swami, Onkar C ·
Evidence suggests elevated GLP-1 and incretin-based therapies may impair counterregulatory responses to hypoglycemia, particularly in patients with pre-existing hypoglycemia unawareness.
Balakumar, Pitchai; Khan, Noohu Abdulla; Easwaran, Vigneshwaran; Orayj, Khalid M ·
Liraglutide, empagliflozin, and gliclazide produced distinct changes in circulating extracellular vesicle subpopulations in T2D, potentially reflecting different vascular effects.
Baldassarre, Maria Pompea Antonia; Carrieri, Federica; Coluzzi, Sara; D'Ascanio, Francesca; Di Pietrantonio, Nadia; Centorame, Giorgia; Pipino, Caterina; Lanuti, Paola; Consoli, Agostino; Formoso, Gloria ·
Jellyfish toxin-derived peptide suppressed gouty arthritis inflammation by downregulating ROS/NF-κB/NLRP3 signaling in vitro and in vivo.
Balde, Akshad; Nazeer, Rasool Abdul ·
Semaglutide unmasked a previously undetected insulinoma in a young woman, presenting as severe refractory hypoglycemia requiring investigation.
Baldera-Rodriguez, Nicole; Simo-Campillo, Natasha; Sanrregre-Oven, Patricia; Lopez, Enrique Capellan; Romano, Ramon; Goicochea, Anahi B ·
HFpEF and AF coexist in 40-60% of cases, mutually worsening each other through adverse remodeling, with emerging metabolic therapies offering new management options.
Ballatore, Andrea; Poggio, Alan; Sullivan, Andrew P; Saglietto, Andrea; De Ferrari, Gaetano Maria; Anselmino, Matteo ·
Available systematic reviews suggest GLP-1 RAs may have cognitive benefits in people with T2DM and cognitive impairment, though evidence remains limited.
Ballum, Hana; Dri, Christine; Liao, Sonya; Yu, Minyi; Le, Gia Han; Wong, Sabrina; Teopiz, Kayla M; Kwan, Angela T H; Ho, Roger; Choi, Hayun; Rosenblat, Joshua D; Vinberg, Maj; K Y Lo, Heidi; McIntyre, Roger S ·
Peripheral and central insulin receptor inhibition produce distinct cytokine and BBB responses to inflammation, suggesting location-specific mechanisms linking insulin resistance to neurodegeneration.
Bandarupalli, Tanmai; Noonan, Cassidy; Hansen, Kim; Weaver, Riley; Baumann, Kristen; Banks, William A; Erickson, Michelle A; Rhea, Elizabeth M ·