Morbidly obese patients showed delayed gastric emptying and impaired gallbladder contraction despite ELEVATED CCK and PYY levels, revealing a paradox of high satiety signals with continued overeating — suggesting satiety resistance.
Key findingMorbidly obese patients had delayed gastric emptying, impaired gallbladder contraction, yet elevated CCK and PYY3-36 levels — a paradox suggesting gut
What the researchers found
Morbidly obese patients had delayed gastric emptying, impaired gallbladder contraction, yet elevated CCK and PYY3-36 levels — a paradox suggesting gut satiety signal resistance in obesity, analogous to leptin resistance.
Why it matters
Relevant for neuropeptides, gut-healing, weight-loss, clinical-trials.
How the study worked
cross-sectional study on neuropeptides, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons.
The journals of gerontology. Series A, Biological sciences and medical sciences, 60(12), 1581-5
Citation
Di Francesco, Vincenzo; Zamboni, Mauro; Dioli, Andrea; Zoico, Elena; Mazzali, Gloria; Omizzolo, Francesca; Bissoli, Luisa; Solerte, Sebastiano B; Benini, Luigi; Bosello, Ottavio. (2005). Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons.. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(12), 1581-5.