Obese People Have Delayed Stomach Emptying But Higher CCK and PYY — A Satiety Paradox
Morbidly obese patients showed delayed gastric emptying and impaired gallbladder contraction despite ELEVATED CCK and PYY levels, revealing a paradox of high satiety signals with continued overeating — suggesting satiety resistance.
Quick Facts
What This Study Found
Morbidly obese patients had delayed gastric emptying, impaired gallbladder contraction, yet elevated CCK and PYY3-36 levels — a paradox suggesting gut satiety signal resistance in obesity, analogous to leptin resistance.
Key Numbers
How They Did This
cross-sectional study on neuropeptides, gut-healing.
Why This Research Matters
Relevant for neuropeptides, gut-healing, weight-loss, clinical-trials.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Morbidly obese patients had delayed gastric emptying, impaired gallbladder contraction, yet elevated CCK and PYY3-36 levels — a paradox suggesting gut
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons.
- Published In:
- The journals of gerontology. Series A, Biological sciences and medical sciences, 60(12), 1581-5 (2005)
- Authors:
- Di Francesco, Vincenzo, Zamboni, Mauro, Dioli, Andrea, Zoico, Elena, Mazzali, Gloria, Omizzolo, Francesca, Bissoli, Luisa, Solerte, Sebastiano B, Benini, Luigi, Bosello, Ottavio
- Database ID:
- RPEP-01027
Evidence Hierarchy
A snapshot of a population at one point in time.
What do these levels mean? →Frequently Asked Questions
What was studied?
Obese People Have Delayed Stomach Emptying But Higher CCK and PYY — A Satiety Paradox
What was found?
Morbidly obese patients showed delayed gastric emptying and impaired gallbladder contraction despite ELEVATED CCK and PYY levels, revealing a paradox of high satiety signals with continued overeating — suggesting satiety resistance.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01027APA
Di Francesco, Vincenzo; Zamboni, Mauro; Dioli, Andrea; Zoico, Elena; Mazzali, Gloria; Omizzolo, Francesca; Bissoli, Luisa; Solerte, Sebastiano B; Benini, Luigi; Bosello, Ottavio. (2005). Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons.. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(12), 1581-5.
MLA
Di Francesco, Vincenzo, et al. "Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons.." The journals of gerontology. Series A, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Delayed postprandial gastric emptying and impaired gallbladd..." RPEP-01027. Retrieved from https://rethinkpeptides.com/research/di-2005-delayed-postprandial-gastric-emptying
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.