GLP-1, PYY, and other gut satiety hormones progressively increased over months after Roux-en-Y gastric bypass, suggesting gut adaptation and providing the hormonal explanation for the surgery's sustained appetite suppression.
Key findingGLP-1 and PYY3-36 progressively increased over months post-RYGB, with the rise correlating with reduced appetite and sustained weight loss — gut hormo
What the researchers found
GLP-1 and PYY3-36 progressively increased over months post-RYGB, with the rise correlating with reduced appetite and sustained weight loss — gut hormonal adaptation (not just restriction) explains bariatric surgery's long-term success.
Why it matters
Relevant for glp-1, weight-loss, gut-healing.
How the study worked
cohort study on glp-1, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety.
The British journal of surgery, 93(2), 210-5
Citation
Borg, C M; le Roux, C W; Ghatei, M A; Bloom, S R; Patel, A G; Aylwin, S J B. (2006). Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety.. The British journal of surgery, 93(2), 210-5.