GHRP-2 Directly Protects Muscle Cells From Steroid-Induced Damage
GHRP-2 directly attenuated dexamethasone-induced muscle atrophy gene expression (atrogin-1, MuRF1) in myocytes through GHS-R activation, demonstrating direct muscle-protective effects independent of systemic GH release.
Quick Facts
What This Study Found
GHRP-2 directly reduced dexamethasone-induced muscle atrophy gene expression (atrogin-1/MAFbx, MuRF1) in C2C12 myocytes via GHS-R — demonstrating direct GH-independent muscle-protective effects against steroid-induced catabolism at the cellular level.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for ghrp, muscle-recovery, hormone-optimization.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding GHRP-2 directly reduced dexamethasone-induced muscle atrophy gene expression (atrogin-1/MAFbx, MuRF1) in C2C12 myocytes via GHS-R — demonstrating dire
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.
- Published In:
- Life sciences, 82(9-10), 460-6 (2008)
- Authors:
- Yamamoto, Daisuke, Ikeshita, Nobuko, Matsubara, Takako, Tasaki, Hiromitsu, Herningtyas, Elizabeth Henny, Toda, Keizo, Iida, Keiji, Takahashi, Yutaka, Kaji, Hidesuke, Chihara, Kazuo, Okimura, Yasuhiko
- Database ID:
- RPEP-01439
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
GHRP-2 Directly Protects Muscle Cells From Steroid-Induced Damage
What was found?
GHRP-2 directly attenuated dexamethasone-induced muscle atrophy gene expression (atrogin-1, MuRF1) in myocytes through GHS-R activation, demonstrating direct muscle-protective effects independent of systemic GH release.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01439APA
Yamamoto, Daisuke; Ikeshita, Nobuko; Matsubara, Takako; Tasaki, Hiromitsu; Herningtyas, Elizabeth Henny; Toda, Keizo; Iida, Keiji; Takahashi, Yutaka; Kaji, Hidesuke; Chihara, Kazuo; Okimura, Yasuhiko. (2008). GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.. Life sciences, 82(9-10), 460-6. https://doi.org/10.1016/j.lfs.2007.11.019
MLA
Yamamoto, Daisuke, et al. "GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.." Life sciences, 2008. https://doi.org/10.1016/j.lfs.2007.11.019
RethinkPeptides
RethinkPeptides Research Database. "GHRP-2, a GHS-R agonist, directly acts on myocytes to attenu..." RPEP-01439. Retrieved from https://rethinkpeptides.com/research/yamamoto-2008-ghrp2-a-ghsr-agonist
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.