Ipamorelin improved nitrogen balance and reduced urea synthesis in steroid-treated rats comparably to GH, demonstrating the GH secretagogue can counteract steroid-induced protein wasting as effectively as direct GH replacement.
Key findingIpamorelin improved nitrogen balance and reduced urea synthesis in dexamethasone-treated rats comparably to GH injection, demonstrating GH secretagogu
What the researchers found
Ipamorelin improved nitrogen balance and reduced urea synthesis in dexamethasone-treated rats comparably to GH injection, demonstrating GH secretagogue equivalence to direct GH for counteracting steroid-induced protein catabolism.
Why it matters
Relevant for ipamorelin, hormone-optimization, muscle-recovery.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 19(5), 426-31
Citation
Aagaard, Niels Kristian; Grøfte, Thorbjørn; Greisen, Jacob; Malmlöf, Kjell; Johansen, Peter B; Grønbaek, Henning; Ørskov, Hans; Tygstrup, Niels; Vilstrup, Hendrik. (2009). Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 19(5), 426-31. https://doi.org/10.1016/j.ghir.2009.01.001