MK-677 for 1 Year in Healthy Elderly: Increased Lean Mass But Also Fat and Insulin
One year of oral MK-677 in healthy older adults increased lean body mass and GH/IGF-1 but also increased fat mass, fasting glucose, and insulin — mixed body composition results with metabolic trade-offs requiring careful clinical consideration.
Quick Facts
What This Study Found
One year of oral MK-677 in healthy older adults (n=65) increased fat-free mass (+1.1 kg), GH, and IGF-1 but also increased fat mass, fasting glucose, and insulin resistance — the most comprehensive long-term RCT showing MK-677's mixed metabolic profile in aging.
Key Numbers
How They Did This
RCT study.
Why This Research Matters
Relevant for mk-677, hormone-optimization, anti-aging, muscle-recovery.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding One year of oral MK-677 in healthy older adults (n=65) increased fat-free mass (+1.1 kg), GH, and IGF-1 but also increased fat mass, fasting glucose,
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
- Published In:
- Annals of internal medicine, 149(9), 601-11 (2008)
- Authors:
- Nass, Ralf, Pezzoli, Suzan S, Oliveri, Mary Clancy, Patrie, James T, Harrell, Frank E, Clasey, Jody L, Heymsfield, Steven B, Bach, Mark A, Vance, Mary Lee, Thorner, Michael O
- Database ID:
- RPEP-01392
Evidence Hierarchy
Frequently Asked Questions
What was studied?
MK-677 for 1 Year in Healthy Elderly: Increased Lean Mass But Also Fat and Insulin
What was found?
One year of oral MK-677 in healthy older adults increased lean body mass and GH/IGF-1 but also increased fat mass, fasting glucose, and insulin — mixed body composition results with metabolic trade-offs requiring careful clinical consideration.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01392APA
Nass, Ralf; Pezzoli, Suzan S; Oliveri, Mary Clancy; Patrie, James T; Harrell, Frank E; Clasey, Jody L; Heymsfield, Steven B; Bach, Mark A; Vance, Mary Lee; Thorner, Michael O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.. Annals of internal medicine, 149(9), 601-11.
MLA
Nass, Ralf, et al. "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.." Annals of internal medicine, 2008.
RethinkPeptides
RethinkPeptides Research Database. "Effects of an oral ghrelin mimetic on body composition and c..." RPEP-01392. Retrieved from https://rethinkpeptides.com/research/nass-2008-effects-of-an-oral
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.