One year of oral MK-677 in healthy older adults increased lean body mass and GH/IGF-1 but also increased fat mass, fasting glucose, and insulin — mixed body composition results with metabolic trade-offs requiring careful clinical consideration.
Key findingOne year of oral MK-677 in healthy older adults (n=65) increased fat-free mass (+1.1 kg), GH, and IGF-1 but also increased fat mass, fasting glucose,
What the researchers found
One year of oral MK-677 in healthy older adults (n=65) increased fat-free mass (+1.1 kg), GH, and IGF-1 but also increased fat mass, fasting glucose, and insulin resistance — the most comprehensive long-term RCT showing MK-677's mixed metabolic profile in aging.
Why it matters
Relevant for mk-677, hormone-optimization, anti-aging, muscle-recovery.
How the study worked
RCT study.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
Annals of internal medicine, 149(9), 601-11
Citation
Nass, Ralf; Pezzoli, Suzan S; Oliveri, Mary Clancy; Patrie, James T; Harrell, Frank E; Clasey, Jody L; Heymsfield, Steven B; Bach, Mark A; Vance, Mary Lee; Thorner, Michael O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.. Annals of internal medicine, 149(9), 601-11.