Explore studies of selank.
Anxiety patients showed accelerated enkephalin degradation, and Selank's anxiolytic effect correlated with inhibition of enkephalin-degrading enzymes, preserving endogenous opioid-mediated anxiety relief.
Zozulya, A A; Kost, N V; Yu Sokolov, O; Gabaeva, M V; Grivennikov, I A; Andreeva, L N; Zolotarev, Y A; Ivanov, S V; Andryushchenko, A V; Myasoedov, N F; Smulevich, A B · Clinical Trial
Selank reduced anxiety behavior in naturally anxious BALB/c mice while modifying enkephalin-degrading enzyme activity, with the anxiolytic effect phenotype-dependent — working most in animals with the greatest enkephalin degradation.
Sokolov, O Yu; Meshavkin, V K; Kost, N V; Zozulya, A A · Animal Study
Selank and tuftsin-family peptides improved adaptive behavior in stressed animals in a phenotype-dependent manner, with different peptides optimal for different emotional reactivity types — supporting personalized peptide anxiolytic therapy.
Kozlovskaya, M M; Kozlovskii, I I; Val'dman, E A; Seredenin, S B · Animal Study
Selank selectively enhanced conditioned avoidance learning and memory in rats with initially low learning ability while minimally affecting normal learners, demonstrating deficit-correcting rather than general cognitive enhancement.
Kozlovskii, I I; Danchev, N D · Animal Study
Naloxone blocked Selank's depriming effect on apomorphine-induced dopaminergic behavioral manifestations, directly confirming opioid system involvement in Selank's anxiolytic mechanism — linking its anti-anxiety action to enkephalin protection.
Meshavkin, V K; Kost, N V; Sokolov, O Yu; Zolotarev, Yu A; Myasoedov, N F; Zozulya, A A · Animal Study
Both Selank and Semax modulated functional connectivity between right amygdala and right temporal cortex regions (fusiform, inferior/middle temporal, parahippocampal gyri) with both shared and peptide-specific effects.
Panikratova, Ya R; Lebedeva, I S; Sokolov, O Yu; Rumshiskaya, A D; Kupriyanov, D A; Kost, N V; Myasoedov, N F · Rct
Selank and phenibut are poorly studied GABAergic drugs sold as US dietary supplements. Phenibut poison control calls have increased substantially, and both carry risks of dependence, withdrawal, and serious adverse effects when misused.
Doyno, Cassandra R; White, C Michael · Review