Selank's anxiolytic effect on apomorphine-induced behavioral changes was blocked by the opioid antagonist naloxone, directly confirming opioid system involvement in Selank's anti-anxiety mechanism.
Key findingNaloxone blocked Selank's depriming effect on apomorphine-induced dopaminergic behavioral manifestations, directly confirming opioid system involvemen
What the researchers found
Naloxone blocked Selank's depriming effect on apomorphine-induced dopaminergic behavioral manifestations, directly confirming opioid system involvement in Selank's anxiolytic mechanism — linking its anti-anxiety action to enkephalin protection.
Why it matters
Relevant for selank, anxiety-mood, opioid-peptides.
How the study worked
animal-study study on selank, anxiety-mood.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.
Bulletin of experimental biology and medicine, 142(5), 598-600
Citation
Meshavkin, V K; Kost, N V; Sokolov, O Yu; Zolotarev, Yu A; Myasoedov, N F; Zozulya, A A. (2006). Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.. Bulletin of experimental biology and medicine, 142(5), 598-600.