Selank's Anti-Anxiety Effect Involves the Opioid System: Naloxone Blocks Its Action
Selank's anxiolytic effect on apomorphine-induced behavioral changes was blocked by the opioid antagonist naloxone, directly confirming opioid system involvement in Selank's anti-anxiety mechanism.
Quick Facts
What This Study Found
Naloxone blocked Selank's depriming effect on apomorphine-induced dopaminergic behavioral manifestations, directly confirming opioid system involvement in Selank's anxiolytic mechanism — linking its anti-anxiety action to enkephalin protection.
Key Numbers
How They Did This
animal-study study on selank, anxiety-mood.
Why This Research Matters
Relevant for selank, anxiety-mood, opioid-peptides.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Naloxone blocked Selank's depriming effect on apomorphine-induced dopaminergic behavioral manifestations, directly confirming opioid system involvemen
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.
- Published In:
- Bulletin of experimental biology and medicine, 142(5), 598-600 (2006)
- Authors:
- Meshavkin, V K(2), Kost, N V(5), Sokolov, O Yu(4), Zolotarev, Yu A, Myasoedov, N F, Zozulya, A A
- Database ID:
- RPEP-01163
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Selank's Anti-Anxiety Effect Involves the Opioid System: Naloxone Blocks Its Action
What was found?
Selank's anxiolytic effect on apomorphine-induced behavioral changes was blocked by the opioid antagonist naloxone, directly confirming opioid system involvement in Selank's anti-anxiety mechanism.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01163APA
Meshavkin, V K; Kost, N V; Sokolov, O Yu; Zolotarev, Yu A; Myasoedov, N F; Zozulya, A A. (2006). Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.. Bulletin of experimental biology and medicine, 142(5), 598-600.
MLA
Meshavkin, V K, et al. "Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system.." Bulletin of experimental biology and medicine, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Naloxone-blocked depriming effect of anxiolytic selank on ap..." RPEP-01163. Retrieved from https://rethinkpeptides.com/research/meshavkin-2006-naloxoneblocked-depriming-effect-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.