GH Secretagogue Appetite Effects Decline With Aging: The Hypothalamic Response Weakens
A GH secretagogue's appetite-stimulating effect was reduced in aged rats and dogs compared to young animals, correlating with decreased hypothalamic GHS receptor expression — aging blunts the appetite side effect.
Quick Facts
What This Study Found
GH secretagogue orexigenic effects were attenuated in aged rats and dogs, correlating with reduced hypothalamic GHS-R expression — age-related decline in receptor density blunts the appetite-stimulating side effect, potentially beneficial for elderly GHS therapy.
Key Numbers
How They Did This
animal-study study on ghrp, weight-loss.
Why This Research Matters
Relevant for ghrp, weight-loss, neuropeptides.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding GH secretagogue orexigenic effects were attenuated in aged rats and dogs, correlating with reduced hypothalamic GHS-R expression — age-related decline
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.
- Published In:
- The journals of gerontology. Series A, Biological sciences and medical sciences, 61(4), 315-22 (2006)
- Authors:
- Rigamonti, Antonello E(2), Bonomo, Sara M(2), Scanniffio, Diego, Cella, Silvano G, Müller, Eugenio E
- Database ID:
- RPEP-01179
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
GH Secretagogue Appetite Effects Decline With Aging: The Hypothalamic Response Weakens
What was found?
A GH secretagogue's appetite-stimulating effect was reduced in aged rats and dogs compared to young animals, correlating with decreased hypothalamic GHS receptor expression — aging blunts the appetite side effect.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01179APA
Rigamonti, Antonello E; Bonomo, Sara M; Scanniffio, Diego; Cella, Silvano G; Müller, Eugenio E. (2006). Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.. The journals of gerontology. Series A, Biological sciences and medical sciences, 61(4), 315-22.
MLA
Rigamonti, Antonello E, et al. "Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.." The journals of gerontology. Series A, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Orexigenic effects of a growth hormone secretagogue and nitr..." RPEP-01179. Retrieved from https://rethinkpeptides.com/research/rigamonti-2006-orexigenic-effects-of-a
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.