A GH secretagogue's appetite-stimulating effect was reduced in aged rats and dogs compared to young animals, correlating with decreased hypothalamic GHS receptor expression — aging blunts the appetite side effect.
Key findingGH secretagogue orexigenic effects were attenuated in aged rats and dogs, correlating with reduced hypothalamic GHS-R expression — age-related decline
What the researchers found
GH secretagogue orexigenic effects were attenuated in aged rats and dogs, correlating with reduced hypothalamic GHS-R expression — age-related decline in receptor density blunts the appetite-stimulating side effect, potentially beneficial for elderly GHS therapy.
Why it matters
Relevant for ghrp, weight-loss, neuropeptides.
How the study worked
animal-study study on ghrp, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.
The journals of gerontology. Series A, Biological sciences and medical sciences, 61(4), 315-22
Citation
Rigamonti, Antonello E; Bonomo, Sara M; Scanniffio, Diego; Cella, Silvano G; Müller, Eugenio E. (2006). Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.. The journals of gerontology. Series A, Biological sciences and medical sciences, 61(4), 315-22.