Ghrelin and PYY Levels in Obesity From Brain Damage: Hypothalamic Obesity Hormones
Patients with hypothalamic obesity from structural brain damage showed elevated ghrelin and reduced PYY compared to BMI-matched controls, suggesting specific gut hormone dysregulation contributes to hypothalamic obesity.
Quick Facts
What This Study Found
Patients with acquired structural hypothalamic damage-induced obesity had elevated ghrelin and reduced PYY3-36 compared to matched controls, suggesting specific gut peptide dysregulation contributes to hypothalamic obesity beyond central appetite circuit damage.
Key Numbers
How They Did This
cross-sectional study on ghrp, neuropeptides.
Why This Research Matters
Relevant for ghrp, neuropeptides, weight-loss, clinical-trials.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Patients with acquired structural hypothalamic damage-induced obesity had elevated ghrelin and reduced PYY3-36 compared to matched controls, suggestin
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?
- Published In:
- The Journal of clinical endocrinology and metabolism, 90(9), 5025-30 (2005)
- Authors:
- Daousi, Christina, MacFarlane, Ian A, English, Patrick J, Wilding, John P H, Patterson, Michael, Dovey, Terence M, Halford, Jason C G, Ghatei, Mohammad A, Pinkney, Jonathan H
- Database ID:
- RPEP-01024
Evidence Hierarchy
A snapshot of a population at one point in time.
What do these levels mean? →Frequently Asked Questions
What was studied?
Ghrelin and PYY Levels in Obesity From Brain Damage: Hypothalamic Obesity Hormones
What was found?
Patients with hypothalamic obesity from structural brain damage showed elevated ghrelin and reduced PYY compared to BMI-matched controls, suggesting specific gut hormone dysregulation contributes to hypothalamic obesity.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01024APA
Daousi, Christina; MacFarlane, Ian A; English, Patrick J; Wilding, John P H; Patterson, Michael; Dovey, Terence M; Halford, Jason C G; Ghatei, Mohammad A; Pinkney, Jonathan H. (2005). Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?. The Journal of clinical endocrinology and metabolism, 90(9), 5025-30.
MLA
Daousi, Christina, et al. "Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?." The Journal of clinical endocrinology and metabolism, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Is there a role for ghrelin and peptide-YY in the pathogenes..." RPEP-01024. Retrieved from https://rethinkpeptides.com/research/daousi-2005-is-there-a-role
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.