Patients with hypothalamic obesity from structural brain damage showed elevated ghrelin and reduced PYY compared to BMI-matched controls, suggesting specific gut hormone dysregulation contributes to hypothalamic obesity.
Key findingPatients with acquired structural hypothalamic damage-induced obesity had elevated ghrelin and reduced PYY3-36 compared to matched controls, suggestin
What the researchers found
Patients with acquired structural hypothalamic damage-induced obesity had elevated ghrelin and reduced PYY3-36 compared to matched controls, suggesting specific gut peptide dysregulation contributes to hypothalamic obesity beyond central appetite circuit damage.
Why it matters
Relevant for ghrp, neuropeptides, weight-loss, clinical-trials.
How the study worked
cross-sectional study on ghrp, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?
The Journal of clinical endocrinology and metabolism, 90(9), 5025-30
Citation
Daousi, Christina; MacFarlane, Ian A; English, Patrick J; Wilding, John P H; Patterson, Michael; Dovey, Terence M; Halford, Jason C G; Ghatei, Mohammad A; Pinkney, Jonathan H. (2005). Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?. The Journal of clinical endocrinology and metabolism, 90(9), 5025-30.