A patient with severe interstitial pneumonia and pulmonary hypertension showed significant improvement with inhaled treprostinil, a prostacyclin analog.
64 mmHgInitial tricuspid regurgitation pressure gradient before treatment
What the researchers found
Inhaled treprostinil improved BNP levels, tricuspid pressure gradient, and oxygen requirements in a patient with severe interstitial pneumonia and pulmonary hypertension.
Why it matters
Demonstrates real-world effectiveness of inhaled treprostinil in a difficult-to-treat patient with combined severe lung disease and pulmonary hypertension.
The numbers in context
- Patient age: 72 years
- Maximum TRPG before treatment: 64 mmHg
- BNP levels and TRPG improved after inhaled treprostinil
- Oxygen requirement decreased after treatment
How the study worked
Single case report of a 72-year-old male patient.
Who was studied
Single 72-year-old male patient with interstitial pneumonia and Group 3 pulmonary hypertension, Japan.
What this study cannot tell us
Single case report cannot establish efficacy. Spontaneous improvement or concurrent treatments may have contributed.
How to read the evidence
Single case report. Lowest level of clinical evidence but useful for illustrating treatment response.
When this study was published
Published in 2025.
The bigger picture
Inhaled treprostinil is an approved therapy for group 3 pulmonary hypertension, and case reports like this add to the growing evidence of its clinical utility in severe lung disease.
Questions still open
- How durable is the response to inhaled treprostinil in interstitial lung disease?
- Should all patients with severe ILD-related PH receive inhaled treprostinil?
Common questions
What is inhaled treprostinil?
Is this treatment standard for lung disease patients with pulmonary hypertension?
Read the original research
Pulmonary Hypertension Associated with Severe Interstitial Pneumonia Successfully Treated with Inhaled Treprostinil: A Case Report.
Internal medicine (Tokyo, Japan)
Citation
Otsuka, Mitsuki; Sonoda, Shiro; Yamada, Takayuki; Aoki, Shotaro; Yasuda, Tomoka; Sawada, Atsushi; Shirai, Tsuyoshi; Tateishi, Tomoya; Furusawa, Haruhiko; Miyazaki, Yasunari. (2025). Pulmonary Hypertension Associated with Severe Interstitial Pneumonia Successfully Treated with Inhaled Treprostinil: A Case Report.. Internal medicine (Tokyo, Japan). https://doi.org/10.2169/internalmedicine.6206-25