The nootropic dipeptide Noopept restored spatial memory and increased BDNF immunoreactivity in the hippocampus after brain damage, providing the neurotrophic mechanism for its cognitive-enhancing and neuroprotective effects.
Key findingNoopept (proline-containing dipeptide) restored spatial memory in brain-lesioned rats and increased hippocampal BDNF immunoreactivity, establishing BD
What the researchers found
Noopept (proline-containing dipeptide) restored spatial memory in brain-lesioned rats and increased hippocampal BDNF immunoreactivity, establishing BDNF upregulation as the neurotrophic mechanism for Noopept's cognitive-enhancing and neuroprotective activities.
Why it matters
Relevant for neuropeptides, neuroprotection, cognitive-enhancement.
How the study worked
animal-study study on neuropeptides, neuroprotection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.
Journal of psychopharmacology (Oxford, England), 21(6), 611-9
Citation
Ostrovskaya, Rita U; Gruden, Marina A; Bobkova, Natalya A; Sewell, Robert D E; Gudasheva, Tatyana A; Samokhin, Alexander N; Seredinin, Sergey B; Noppe, Wim; Sherstnev, Vladimir V; Morozova-Roche, Ludmilla A. (2007). The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.. Journal of psychopharmacology (Oxford, England), 21(6), 611-9.