Semax Specifically Binds Brain Cells and Increases BDNF Protein Levels
Semax showed specific binding to rat brain cells and increased BDNF protein levels, confirming it has a dedicated brain receptor and works through neurotrophin enhancement for cognitive and neuroprotective effects.
Quick Facts
What This Study Found
Semax (ACTH 4-10 analog) showed specific binding to rat brain tissue and increased brain-derived neurotrophic factor (BDNF) protein levels, confirming receptor-mediated neurotrophin enhancement as the mechanism for its nootropic and neuroprotective activities.
Key Numbers
How They Did This
animal-study study on semax, neuroprotection.
Why This Research Matters
Relevant for semax, neuroprotection, cognitive-enhancement.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Semax (ACTH 4-10 analog) showed specific binding to rat brain tissue and increased brain-derived neurotrophic factor (BDNF) protein levels, confirming
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.
- Published In:
- Journal of neurochemistry, 97 Suppl 1, 82-6 (2006)
- Authors:
- Dolotov, Oleg V(2), Karpenko, Ekaterina A(2), Seredenina, Tamara S(2), Inozemtseva, Lyudmila S, Levitskaya, Natalia G, Zolotarev, Yuriy A, Kamensky, Andrey A, Grivennikov, Igor A, Engele, Juergen, Myasoedov, Nikolay F
- Database ID:
- RPEP-01130
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Semax Specifically Binds Brain Cells and Increases BDNF Protein Levels
What was found?
Semax showed specific binding to rat brain cells and increased BDNF protein levels, confirming it has a dedicated brain receptor and works through neurotrophin enhancement for cognitive and neuroprotective effects.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01130APA
Dolotov, Oleg V; Karpenko, Ekaterina A; Seredenina, Tamara S; Inozemtseva, Lyudmila S; Levitskaya, Natalia G; Zolotarev, Yuriy A; Kamensky, Andrey A; Grivennikov, Igor A; Engele, Juergen; Myasoedov, Nikolay F. (2006). Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.. Journal of neurochemistry, 97 Suppl 1, 82-6.
MLA
Dolotov, Oleg V, et al. "Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.." Journal of neurochemistry, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Semax, an analogue of adrenocorticotropin (4-10), binds spec..." RPEP-01130. Retrieved from https://rethinkpeptides.com/research/dolotov-2006-semax-an-analogue-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.