Semax Boosts Brain-Derived Neurotrophic Factor (BDNF) in the Hippocampus
The nootropic peptide Semax (ACTH 4-10 analog) increased BDNF and TrkB receptor expression in the rat hippocampus — providing a molecular mechanism for its cognitive-enhancing and neuroprotective effects.
Quick Facts
What This Study Found
Semax upregulated BDNF mRNA and TrkB receptor expression in the rat hippocampus, providing the neurotrophic molecular mechanism for its documented cognitive enhancement and neuroprotective effects — BDNF is the brain's primary growth and survival factor.
Key Numbers
How They Did This
animal-study study on semax, neuroprotection.
Why This Research Matters
Relevant for semax, neuroprotection, cognitive-enhancement.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Semax upregulated BDNF mRNA and TrkB receptor expression in the rat hippocampus, providing the neurotrophic molecular mechanism for its documented cog
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.
- Published In:
- Brain research, 1117(1), 54-60 (2006)
- Authors:
- Dolotov, Oleg V(2), Karpenko, Ekaterina A(2), Inozemtseva, Lyudmila S(2), Seredenina, Tamara S, Levitskaya, Natalia G, Rozyczka, Joanna, Dubynina, Elena V, Novosadova, Ekaterina V, Andreeva, Lyudmila A, Alfeeva, Lyudmila Yu, Kamensky, Andrey A, Grivennikov, Igor A, Myasoedov, Nikolay F, Engele, Jürgen
- Database ID:
- RPEP-01129
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Semax Boosts Brain-Derived Neurotrophic Factor (BDNF) in the Hippocampus
What was found?
The nootropic peptide Semax (ACTH 4-10 analog) increased BDNF and TrkB receptor expression in the rat hippocampus — providing a molecular mechanism for its cognitive-enhancing and neuroprotective effects.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01129APA
Dolotov, Oleg V; Karpenko, Ekaterina A; Inozemtseva, Lyudmila S; Seredenina, Tamara S; Levitskaya, Natalia G; Rozyczka, Joanna; Dubynina, Elena V; Novosadova, Ekaterina V; Andreeva, Lyudmila A; Alfeeva, Lyudmila Yu; Kamensky, Andrey A; Grivennikov, Igor A; Myasoedov, Nikolay F; Engele, Jürgen. (2006). Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.. Brain research, 1117(1), 54-60.
MLA
Dolotov, Oleg V, et al. "Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.." Brain research, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Semax, an analog of ACTH(4-10) with cognitive effects, regul..." RPEP-01129. Retrieved from https://rethinkpeptides.com/research/dolotov-2006-semax-an-analog-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.