Protein Before Duodenal Fat Amplifies the Satiety Response in Healthy Men
Protein preload before duodenal fat infusion enhanced satiety and reduced energy intake compared to fat alone, with greater CCK and GLP-1 responses — supporting protein-fat meal sequencing for appetite control.
Quick Facts
What This Study Found
Protein preload before duodenal fat perfusion in healthy men amplified satiety, enhanced CCK/GLP-1 release, and reduced subsequent energy intake compared to fat alone — supporting strategic macronutrient sequencing for appetite management.
Key Numbers
How They Did This
RCT study on bioactive-food-peptides, weight-loss.
Why This Research Matters
Relevant for bioactive-food-peptides, weight-loss.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Protein preload before duodenal fat perfusion in healthy men amplified satiety, enhanced CCK/GLP-1 release, and reduced subsequent energy intake compa
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects.
- Published In:
- American journal of physiology. Regulatory, integrative and comparative physiology, 289(4), R1042-7 (2005)
- Authors:
- Oesch, Sibylle, Degen, Lukas(2), Beglinger, Christoph(3)
- Database ID:
- RPEP-01072
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Protein Before Duodenal Fat Amplifies the Satiety Response in Healthy Men
What was found?
Protein preload before duodenal fat infusion enhanced satiety and reduced energy intake compared to fat alone, with greater CCK and GLP-1 responses — supporting protein-fat meal sequencing for appetite control.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01072APA
Oesch, Sibylle; Degen, Lukas; Beglinger, Christoph. (2005). Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects.. American journal of physiology. Regulatory, integrative and comparative physiology, 289(4), R1042-7.
MLA
Oesch, Sibylle, et al. "Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects.." American journal of physiology. Regulatory, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Effect of a protein preload on food intake and satiety feeli..." RPEP-01072. Retrieved from https://rethinkpeptides.com/research/oesch-2005-effect-of-a-protein
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.