Protein preload before duodenal fat infusion enhanced satiety and reduced energy intake compared to fat alone, with greater CCK and GLP-1 responses — supporting protein-fat meal sequencing for appetite control.
Key findingProtein preload before duodenal fat perfusion in healthy men amplified satiety, enhanced CCK/GLP-1 release, and reduced subsequent energy intake compa
What the researchers found
Protein preload before duodenal fat perfusion in healthy men amplified satiety, enhanced CCK/GLP-1 release, and reduced subsequent energy intake compared to fat alone — supporting strategic macronutrient sequencing for appetite management.
Why it matters
Relevant for bioactive-food-peptides, weight-loss.
How the study worked
RCT study on bioactive-food-peptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects.
American journal of physiology. Regulatory, integrative and comparative physiology, 289(4), R1042-7
Citation
Oesch, Sibylle; Degen, Lukas; Beglinger, Christoph. (2005). Effect of a protein preload on food intake and satiety feelings in response to duodenal fat perfusions in healthy male subjects.. American journal of physiology. Regulatory, integrative and comparative physiology, 289(4), R1042-7.