Protein hydrolysates directly stimulated CCK release from enteroendocrine cells and acted as partial CCK1 receptor agonists, revealing how protein digestion products directly trigger satiety hormone secretion.
Key findingProtein hydrolysates directly stimulated CCK secretion from STC-1 enteroendocrine cells and showed partial CCK1 receptor agonist activity, demonstrati
What the researchers found
Protein hydrolysates directly stimulated CCK secretion from STC-1 enteroendocrine cells and showed partial CCK1 receptor agonist activity, demonstrating dual mechanisms: dietary peptides both trigger satiety hormone release AND directly activate satiety receptors.
Why it matters
Relevant for bioactive-food-peptides, neuropeptides, weight-loss.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonists of the CCK1 receptor.
Journal of agricultural and food chemistry, 56(3), 837-43
Citation
Foltz, Martin; Ansems, Patrick; Schwarz, Jessica; Tasker, Maria C; Lourbakos, Afrodite; Gerhardt, Cindy C. (2008). Protein hydrolysates induce CCK release from enteroendocrine cells and act as partial agonists of the CCK1 receptor.. Journal of agricultural and food chemistry, 56(3), 837-43. https://doi.org/10.1021/jf072611h