This comprehensive 2006 review covers all major gut peptides (GLP-1, PYY, CCK, ghrelin, oxyntomodulin, amylin, PP) in food intake regulation, with GLP-1 and PYY agonists identified as the most promising obesity drug targets.
Key findingComplete 2006 mapping of gut peptide appetite regulation: GLP-1 and PYY3-36 as top obesity targets, with CCK, oxyntomodulin, amylin, and PP providing
What the researchers found
Complete 2006 mapping of gut peptide appetite regulation: GLP-1 and PYY3-36 as top obesity targets, with CCK, oxyntomodulin, amylin, and PP providing complementary satiety signals — ghrelin as the sole orexigenic gut peptide.
Why it matters
Relevant for glp-1, neuropeptides, weight-loss.
How the study worked
review study on glp-1, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Gut peptides in the regulation of food intake and energy homeostasis.
Endocrine reviews, 27(7), 719-27
Citation
Murphy, Kevin G; Dhillo, Waljit S; Bloom, Stephen R. (2006). Gut peptides in the regulation of food intake and energy homeostasis.. Endocrine reviews, 27(7), 719-27.