CCK-8 and CCK-33 both inhibited food intake through hepatic vagal afferents, with CCK-33 showing longer-lasting satiety — different CCK forms use the same pathway but with distinct temporal profiles.
Key findingBoth CCK-8 and CCK-33 reduced food intake through hepatic branch vagal afferents in rats, but CCK-33 produced more sustained satiety — demonstrating s
What the researchers found
Both CCK-8 and CCK-33 reduced food intake through hepatic branch vagal afferents in rats, but CCK-33 produced more sustained satiety — demonstrating shared pathway with temporal differences between CCK molecular forms.
Why it matters
Relevant for neuropeptides, gut-healing, weight-loss, receptor-signaling.
How the study worked
animal-study study on neuropeptides, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation.
American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R456-R462
Citation
Eisen, S; Phillips, R J; Geary, N; Baronowsky, E A; Powley, T L; Smith, G P. (2005). Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation.. American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R456-R462.