Two Forms of CCK Suppress Appetite Through the Same Liver Nerve Pathway
CCK-8 and CCK-33 both inhibited food intake through hepatic vagal afferents, with CCK-33 showing longer-lasting satiety — different CCK forms use the same pathway but with distinct temporal profiles.
Quick Facts
What This Study Found
Both CCK-8 and CCK-33 reduced food intake through hepatic branch vagal afferents in rats, but CCK-33 produced more sustained satiety — demonstrating shared pathway with temporal differences between CCK molecular forms.
Key Numbers
How They Did This
animal-study study on neuropeptides, gut-healing.
Why This Research Matters
Relevant for neuropeptides, gut-healing, weight-loss, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Both CCK-8 and CCK-33 reduced food intake through hepatic branch vagal afferents in rats, but CCK-33 produced more sustained satiety — demonstrating s
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation.
- Published In:
- American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R456-R462 (2005)
- Authors:
- Eisen, S, Phillips, R J, Geary, N, Baronowsky, E A, Powley, T L, Smith, G P
- Database ID:
- RPEP-01030
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Two Forms of CCK Suppress Appetite Through the Same Liver Nerve Pathway
What was found?
CCK-8 and CCK-33 both inhibited food intake through hepatic vagal afferents, with CCK-33 showing longer-lasting satiety — different CCK forms use the same pathway but with distinct temporal profiles.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01030APA
Eisen, S; Phillips, R J; Geary, N; Baronowsky, E A; Powley, T L; Smith, G P. (2005). Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation.. American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R456-R462.
MLA
Eisen, S, et al. "Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation.." American journal of physiology. Regulatory, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Inhibitory effects on intake of cholecystokinin-8 and cholec..." RPEP-01030. Retrieved from https://rethinkpeptides.com/research/eisen-2005-inhibitory-effects-on-intake
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.