Urotensin II showed inverse correlation with sympathetic nerve activity and natriuretic peptides in end-stage renal disease, suggesting a counter-regulatory relationship in the cardiorenal axis.
Key findingPlasma urotensin II inversely correlated with muscle sympathetic nerve activity and cardiac natriuretic peptides in ESRD patients, suggesting urotensi
What the researchers found
Plasma urotensin II inversely correlated with muscle sympathetic nerve activity and cardiac natriuretic peptides in ESRD patients, suggesting urotensin II serves a counter-regulatory role in the sympathetic-peptide axis in cardiorenal disease.
Why it matters
Relevant for neuropeptides, kidney, cardiovascular, natriuretic-peptides.
How the study worked
cross-sectional study on neuropeptides, kidney.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Urotensin II in end-stage renal disease: an inverse correlate of sympathetic function and cardiac natriuretic peptides.
Journal of nephrology, 18(6), 727-32
Citation
Mallamaci, Francesca; Cutrupi, Sebastiano; Pizzini, Patrizia; Tripepi, Giovanni; Zoccali, Carmine. (2005). Urotensin II in end-stage renal disease: an inverse correlate of sympathetic function and cardiac natriuretic peptides.. Journal of nephrology, 18(6), 727-32.