Intraluminal peptide releasing factors triggered by dietary proteins and fats are key regulators of CCK secretion, coordinating digestion and signaling fullness.
Luminal peptide triggersSpecific peptide factors released during protein/fat digestion are the key signals triggering CCK secretion
What the researchers found
Intraluminal peptide factors, released in response to dietary proteins and fats, are key regulators of CCK secretion that coordinate digestion.
Why it matters
CCK controls how we digest food. Understanding its release mechanisms is important for treating digestive disorders and for weight management, since CCK also signals fullness to the brain.
How the study worked
Narrative review of published research on CCK secretion mechanisms, luminal releasing factors, and their roles in digestive physiology.
What this study cannot tell us
Narrative review from 1995. Some mechanisms have been further clarified since publication. The luminal releasing factors were not fully characterized at the time.
How to read the evidence
Moderate — comprehensive review of CCK release mechanisms as of 1995.
When this study was published
Published in 1995 (31 years ago). CCK release mechanisms have been further characterized; the basic principles remain valid.
The bigger picture
CCK is one of the body's main "I'm full" signals. Understanding what triggers its release could help develop dietary or pharmaceutical approaches to control appetite and improve digestion.
Questions still open
- Could CCK-releasing dietary strategies help with weight management?
- Are CCK-releasing factors altered in digestive disorders?
Common questions
What is CCK?
Why does protein make you feel full?
Read the original research
Regulation of cholecystokinin secretion by intraluminal releasing factors.
The American journal of physiology, 269(3 Pt 1), G319-27
Citation
Liddle, R A. (1995). Regulation of cholecystokinin secretion by intraluminal releasing factors.. The American journal of physiology, 269(3 Pt 1), G319-27.