Dietary Fiber Fermentation Raises GLP-1 and PYY Satiety Hormones in Both Rats and Humans
Dietary lactitol fermentation in the colon increased circulating PYY and GLP-1 in both rats and humans, demonstrating that gut bacteria fermenting fiber can boost satiety hormones — a prebiotic appetite-control mechanism.
Quick Facts
What This Study Found
Lactitol colonic fermentation increased circulating PYY and GLP-1 in rats and humans, establishing that short-chain fatty acid production from dietary fiber fermentation stimulates L-cell satiety peptide secretion — a prebiotic mechanism for appetite regulation.
Key Numbers
How They Did This
clinical-trial study on glp-1, neuropeptides.
Why This Research Matters
Relevant for glp-1, neuropeptides, gut-healing, bioactive-food-peptides.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Lactitol colonic fermentation increased circulating PYY and GLP-1 in rats and humans, establishing that short-chain fatty acid production from dietary
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.
- Published In:
- Nutrition (Burbank, Los Angeles County, Calif.), 21(10), 1036-43 (2005)
- Authors:
- Gee, Jennifer M, Johnson, Ian T
- Database ID:
- RPEP-01034
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Dietary Fiber Fermentation Raises GLP-1 and PYY Satiety Hormones in Both Rats and Humans
What was found?
Dietary lactitol fermentation in the colon increased circulating PYY and GLP-1 in both rats and humans, demonstrating that gut bacteria fermenting fiber can boost satiety hormones — a prebiotic appetite-control mechanism.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01034APA
Gee, Jennifer M; Johnson, Ian T. (2005). Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.. Nutrition (Burbank, Los Angeles County, Calif.), 21(10), 1036-43.
MLA
Gee, Jennifer M, et al. "Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.." Nutrition (Burbank, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Dietary lactitol fermentation increases circulating peptide ..." RPEP-01034. Retrieved from https://rethinkpeptides.com/research/gee-2005-dietary-lactitol-fermentation-increases
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.