Dietary lactitol fermentation in the colon increased circulating PYY and GLP-1 in both rats and humans, demonstrating that gut bacteria fermenting fiber can boost satiety hormones — a prebiotic appetite-control mechanism.
Key findingLactitol colonic fermentation increased circulating PYY and GLP-1 in rats and humans, establishing that short-chain fatty acid production from dietary
What the researchers found
Lactitol colonic fermentation increased circulating PYY and GLP-1 in rats and humans, establishing that short-chain fatty acid production from dietary fiber fermentation stimulates L-cell satiety peptide secretion — a prebiotic mechanism for appetite regulation.
Why it matters
Relevant for glp-1, neuropeptides, gut-healing, bioactive-food-peptides.
How the study worked
clinical-trial study on glp-1, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.
Nutrition (Burbank, Los Angeles County, Calif.), 21(10), 1036-43
Citation
Gee, Jennifer M; Johnson, Ian T. (2005). Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.. Nutrition (Burbank, Los Angeles County, Calif.), 21(10), 1036-43.