Gut Hormones After Gastric Bypass: The Hormonal Explanation for Lasting Weight Loss
Enhanced postprandial GLP-1, PYY, and reduced ghrelin after Roux-en-Y gastric bypass mediated the sustained appetite reduction and weight loss, with hormonal changes persisting long-term — the hormonal basis for surgical success.
Quick Facts
What This Study Found
Enhanced GLP-1 and PYY responses with suppressed ghrelin after RYGB mediated sustained appetite reduction and weight loss, with gut hormone changes persisting years post-surgery — establishing hormonal modification (not just restriction) as the primary mechanism of bariatric success.
Key Numbers
How They Did This
clinical-trial study on glp-1, neuropeptides.
Why This Research Matters
Relevant for glp-1, neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Enhanced GLP-1 and PYY responses with suppressed ghrelin after RYGB mediated sustained appetite reduction and weight loss, with gut hormone changes pe
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass.
- Published In:
- Annals of surgery, 246(5), 780-5 (2007)
- Authors:
- le Roux, Carel W(18), Welbourn, Richard(2), Werling, Malin(2), Osborne, Alan, Kokkinos, Alexander, Laurenius, Anna, Lönroth, Hans, Fändriks, Lars, Ghatei, Mohammad A, Bloom, Stephen R, Olbers, Torsten
- Database ID:
- RPEP-01255
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Gut Hormones After Gastric Bypass: The Hormonal Explanation for Lasting Weight Loss
What was found?
Enhanced postprandial GLP-1, PYY, and reduced ghrelin after Roux-en-Y gastric bypass mediated the sustained appetite reduction and weight loss, with hormonal changes persisting long-term — the hormonal basis for surgical success.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01255APA
le Roux, Carel W; Welbourn, Richard; Werling, Malin; Osborne, Alan; Kokkinos, Alexander; Laurenius, Anna; Lönroth, Hans; Fändriks, Lars; Ghatei, Mohammad A; Bloom, Stephen R; Olbers, Torsten. (2007). Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass.. Annals of surgery, 246(5), 780-5.
MLA
le Roux, Carel W, et al. "Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass.." Annals of surgery, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Gut hormones as mediators of appetite and weight loss after ..." RPEP-01255. Retrieved from https://rethinkpeptides.com/research/le-2007-gut-hormones-as-mediators
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.