Enhanced postprandial GLP-1, PYY, and reduced ghrelin after Roux-en-Y gastric bypass mediated the sustained appetite reduction and weight loss, with hormonal changes persisting long-term — the hormonal basis for surgical success.
Key findingEnhanced GLP-1 and PYY responses with suppressed ghrelin after RYGB mediated sustained appetite reduction and weight loss, with gut hormone changes pe
What the researchers found
Enhanced GLP-1 and PYY responses with suppressed ghrelin after RYGB mediated sustained appetite reduction and weight loss, with gut hormone changes persisting years post-surgery — establishing hormonal modification (not just restriction) as the primary mechanism of bariatric success.
Why it matters
Relevant for glp-1, neuropeptides, weight-loss.
How the study worked
clinical-trial study on glp-1, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass.
Annals of surgery, 246(5), 780-5
Citation
le Roux, Carel W; Welbourn, Richard; Werling, Malin; Osborne, Alan; Kokkinos, Alexander; Laurenius, Anna; Lönroth, Hans; Fändriks, Lars; Ghatei, Mohammad A; Bloom, Stephen R; Olbers, Torsten. (2007). Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass.. Annals of surgery, 246(5), 780-5.