Women with bulimia nervosa showed blunted ghrelin suppression and altered PYY responses after meals compared to controls, suggesting disrupted gut-brain appetite signaling contributes to binge-eating cycles.
Key findingBulimia nervosa patients demonstrated blunted post-meal ghrelin suppression and altered PYY3-36 response compared to healthy controls, indicating disr
What the researchers found
Bulimia nervosa patients demonstrated blunted post-meal ghrelin suppression and altered PYY3-36 response compared to healthy controls, indicating disrupted gut peptide satiety signaling that may perpetuate the binge-purge cycle.
Why it matters
Relevant for ghrp, gut-healing, anxiety-mood.
How the study worked
clinical-trial study on ghrp, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Altered ghrelin and peptide YY responses to meals in bulimia nervosa.
Clinical endocrinology, 62(1), 74-8
Citation
Kojima, Shinya; Nakahara, Toshihiro; Nagai, Nobuatsu; Muranaga, Tetsuro; Tanaka, Muneki; Yasuhara, Daisuke; Masuda, Akinori; Date, Yukari; Ueno, Hiroaki; Nakazato, Masamitsu; Naruo, Tetsuro. (2005). Altered ghrelin and peptide YY responses to meals in bulimia nervosa.. Clinical endocrinology, 62(1), 74-8.