GH secretagogues modulate the hypothalamus-pituitary-adrenal (HPA) stress axis through GABA, mineralocorticoid, and GH-related pathways, explaining their effects on cortisol and stress responses beyond GH release.
Key findingGH secretagogues modulate HPA axis regulation through interactions with GABAergic, mineralocorticoid, and somatotropic pathways — explaining cortisol
What the researchers found
GH secretagogues modulate HPA axis regulation through interactions with GABAergic, mineralocorticoid, and somatotropic pathways — explaining cortisol co-release during GH stimulation and the stress-axis implications of chronic GH secretagogue use.
Why it matters
Relevant for ghrp, hormone-optimization, anxiety-mood.
How the study worked
review study on ghrp, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: effects of GABA-, mineralocorticoid-, and GH-Secretagogue-receptor modulation.
TheScientificWorldJournal, 6, 1-11
Citation
Giordano, Roberta; Pellegrino, Micaela; Picu, Andreea; Bonelli, Lorenza; Balbo, Marcella; Berardelli, Rita; Lanfranco, Fabio; Ghigo, Ezio; Arvat, Emanuela. (2006). Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: effects of GABA-, mineralocorticoid-, and GH-Secretagogue-receptor modulation.. TheScientificWorldJournal, 6, 1-11.