Postprandial GLP-1, PYY, and other regulatory peptides dramatically increased after gastric bypass, with the hormonal changes correlating with reduced appetite and food intake — hormonal reprogramming drives surgical success.
Key findingPostprandial GLP-1, PYY3-36, and other gut regulatory peptides dramatically increased following gastric bypass, with enhanced hormonal satiety signali
What the researchers found
Postprandial GLP-1, PYY3-36, and other gut regulatory peptides dramatically increased following gastric bypass, with enhanced hormonal satiety signaling correlating with reduced appetite and caloric intake — hormonal reprogramming, not restriction, as the primary surgical mechanism.
Why it matters
Relevant for glp-1, neuropeptides, weight-loss.
How the study worked
clinical-trial study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Postprandial changes in gut regulatory peptides in gastric bypass patients.
International journal of obesity (2005), 32(11), 1640-6
Citation
Holdstock, C; Zethelius, B; Sundbom, M; Karlsson, F A; Edén Engström, B. (2008). Postprandial changes in gut regulatory peptides in gastric bypass patients.. International journal of obesity (2005), 32(11), 1640-6. https://doi.org/10.1038/ijo.2008.157