Gut Hormone Changes After Gastric Bypass Explain the Dramatic Appetite Reduction
Postprandial GLP-1, PYY, and other regulatory peptides dramatically increased after gastric bypass, with the hormonal changes correlating with reduced appetite and food intake — hormonal reprogramming drives surgical success.
Quick Facts
What This Study Found
Postprandial GLP-1, PYY3-36, and other gut regulatory peptides dramatically increased following gastric bypass, with enhanced hormonal satiety signaling correlating with reduced appetite and caloric intake — hormonal reprogramming, not restriction, as the primary surgical mechanism.
Key Numbers
How They Did This
clinical-trial study.
Why This Research Matters
Relevant for glp-1, neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Postprandial GLP-1, PYY3-36, and other gut regulatory peptides dramatically increased following gastric bypass, with enhanced hormonal satiety signali
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Postprandial changes in gut regulatory peptides in gastric bypass patients.
- Published In:
- International journal of obesity (2005), 32(11), 1640-6 (2008)
- Authors:
- Holdstock, C, Zethelius, B, Sundbom, M, Karlsson, F A, Edén Engström, B
- Database ID:
- RPEP-01355
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Gut Hormone Changes After Gastric Bypass Explain the Dramatic Appetite Reduction
What was found?
Postprandial GLP-1, PYY, and other regulatory peptides dramatically increased after gastric bypass, with the hormonal changes correlating with reduced appetite and food intake — hormonal reprogramming drives surgical success.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01355APA
Holdstock, C; Zethelius, B; Sundbom, M; Karlsson, F A; Edén Engström, B. (2008). Postprandial changes in gut regulatory peptides in gastric bypass patients.. International journal of obesity (2005), 32(11), 1640-6. https://doi.org/10.1038/ijo.2008.157
MLA
Holdstock, C, et al. "Postprandial changes in gut regulatory peptides in gastric bypass patients.." International journal of obesity (2005), 2008. https://doi.org/10.1038/ijo.2008.157
RethinkPeptides
RethinkPeptides Research Database. "Postprandial changes in gut regulatory peptides in gastric b..." RPEP-01355. Retrieved from https://rethinkpeptides.com/research/holdstock-2008-postprandial-changes-in-gut
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.