Ghrelin, PYY, and GLP-1 levels were altered in pediatric chronic renal failure patients, changing further after dialysis and transplant — explaining the appetite disturbances that affect growth in children with kidney disease.
Key findingPediatric CRF patients showed altered ghrelin, PYY3-36, and GLP-1 profiles that changed with dialysis and post-transplant, with appetite hormone distu
What the researchers found
Pediatric CRF patients showed altered ghrelin, PYY3-36, and GLP-1 profiles that changed with dialysis and post-transplant, with appetite hormone disturbances correlating with growth impairment — explaining appetite-growth dysfunction in pediatric kidney disease.
Why it matters
Relevant for neuropeptides, kidney, weight-loss.
How the study worked
clinical-trial study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(2), 643-6
Citation
Arbeiter, Anja K; Büscher, Rainer; Petersenn, Stephan; Hauffa, Berthold P; Mann, Klaus; Hoyer, Peter F. (2009). Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(2), 643-6. https://doi.org/10.1093/ndt/gfn529