Gastroparesis Risk Comparison: GLP-1 Drugs vs Bariatric Surgery vs Other Approaches

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.

Aneke-Nash, Chino et al.·BMJ open gastroenterology·2025·Moderate Evidencecohort
RPEP-09948CohortModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
cohort
Evidence
Moderate Evidence
Sample
N=not specified
Participants
Adults with obesity without type 2 diabetes treated with semaglutide, bupropion-naltrexone, or sleeve gastrectomy

What This Study Found

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.

Key Numbers

Specific incidence rates not detailed in abstract; study used a large commercial claims database for comparison.

How They Did This

In publication.

Why This Research Matters

Relevant to peptide therapeutics.

The Bigger Picture

Advances peptide evidence.

What This Study Doesn't Tell Us

In publication.

Questions This Raises

  • ?Long-term implications?
  • ?Evidence comparison?
  • ?Next steps?

Trust & Context

Key Stat:
Key finding Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and b
Evidence Grade:
Based on design.
Study Age:
Published in 2025.
Original Title:
Comparing the risk of gastroparesis following different modalities for treating obesity: semaglutide versus bupropion-naltrexone versus sleeve gastrectomy - a retrospective cohort study.
Published In:
BMJ open gastroenterology, 12(1) (2025)
Database ID:
RPEP-09948

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Frequently Asked Questions

What does this mean?

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.

How reliable?

Consult publication.

Read More on RethinkPeptides

Cite This Study

RPEP-09948·https://rethinkpeptides.com/research/RPEP-09948

APA

Aneke-Nash, Chino; Hung, Kay Su; Wall-Wieler, Elizabeth; Zheng, Feibi; Sharaiha, Reem Z. (2025). Comparing the risk of gastroparesis following different modalities for treating obesity: semaglutide versus bupropion-naltrexone versus sleeve gastrectomy - a retrospective cohort study.. BMJ open gastroenterology, 12(1). https://doi.org/10.1136/bmjgast-2024-001704

MLA

Aneke-Nash, Chino, et al. "Comparing the risk of gastroparesis following different modalities for treating obesity: semaglutide versus bupropion-naltrexone versus sleeve gastrectomy - a retrospective cohort study.." BMJ open gastroenterology, 2025. https://doi.org/10.1136/bmjgast-2024-001704

RethinkPeptides

RethinkPeptides Research Database. "Comparing the risk of gastroparesis following different moda..." RPEP-09948. Retrieved from https://rethinkpeptides.com/research/aneke-nash-2025-comparing-the-risk-of

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.