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Study breakdown

Gastroparesis Risk Comparison: GLP-1 Drugs vs Bariatric Surgery vs Other Approaches

CohortModerate evidence
The takeaway

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.

Key finding

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and b

What the researchers found

Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.

Why it matters

Relevant to peptide therapeutics.

The numbers in context

Specific incidence rates not detailed in abstract; study used a large commercial claims database for comparison.

How the study worked

In publication.

Who was studied

Adults with obesity without type 2 diabetes treated with semaglutide, bupropion-naltrexone, or sleeve gastrectomy

What this study cannot tell us

In publication.

How to read the evidence

Based on design.

When this study was published

Published in 2025.

The bigger picture

Advances peptide evidence.

Questions still open

  • Long-term implications?
  • Evidence comparison?
  • Next steps?

Common questions

What does this mean?
Comparison of gastroparesis risk across different weight loss modalities including GLP-1 drugs and bariatric surgery helps quantify this GI complication by treatment approach.
How reliable?
Consult publication.

Read the original research

Comparing the risk of gastroparesis following different modalities for treating obesity: semaglutide versus bupropion-naltrexone versus sleeve gastrectomy - a retrospective cohort study.

BMJ open gastroenterology, 12(1)

Citation

Aneke-Nash, Chino; Hung, Kay Su; Wall-Wieler, Elizabeth; Zheng, Feibi; Sharaiha, Reem Z. (2025). Comparing the risk of gastroparesis following different modalities for treating obesity: semaglutide versus bupropion-naltrexone versus sleeve gastrectomy - a retrospective cohort study.. BMJ open gastroenterology, 12(1). https://doi.org/10.1136/bmjgast-2024-001704