Liraglutide Protects Stomach From NSAID-Induced Ulcer Damage
Liraglutide protected against indomethacin-induced gastric damage in a preclinical model, adding gastroprotection to GLP-1 drug benefits through anti-inflammatory mechanisms.
Quick Facts
What This Study Found
Liraglutide protected against indomethacin-induced gastric damage in a preclinical model, adding gastroprotection to GLP-1 drug benefits through anti-inflammatory mechanisms.
Key Numbers
63 male Wistar rats in 7 groups. STZ for diabetes induction. Indomethacin for ulcer induction. Liraglutide at 0.2 mg/kg and 0.4 mg/kg. Compared to omeprazole.
How They Did This
In publication.
Why This Research Matters
Relevant to peptide therapeutics.
The Bigger Picture
Advances peptide evidence.
What This Study Doesn't Tell Us
In publication.
Questions This Raises
- ?Long-term implications?
- ?Evidence comparison?
- ?Next steps?
Trust & Context
- Key Stat:
- Key finding Liraglutide protected against indomethacin-induced gastric damage in a preclinical model, adding gas
- Evidence Grade:
- Based on design.
- Study Age:
- Published in 2025.
- Original Title:
- The effect of liraglutide, a GLP-1 analog, on indomethacin-induced gastric ulcers in diabetic rats.
- Published In:
- Acta cirurgica brasileira, 40, e407325 (2025)
- Authors:
- Arslan, Huseyin Emre, Teksen, Yasemin(2), Ozatik, Orhan(2), Algin, Mustafa Cem
- Database ID:
- RPEP-09989
Evidence Hierarchy
Frequently Asked Questions
What does this mean?
Liraglutide protected against indomethacin-induced gastric damage in a preclinical model, adding gastroprotection to GLP-1 drug benefits through anti-inflammatory mechanisms.
How reliable?
Consult publication.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-09989APA
Arslan, Huseyin Emre; Teksen, Yasemin; Ozatik, Orhan; Algin, Mustafa Cem. (2025). The effect of liraglutide, a GLP-1 analog, on indomethacin-induced gastric ulcers in diabetic rats.. Acta cirurgica brasileira, 40, e407325. https://doi.org/10.1590/acb407325
MLA
Arslan, Huseyin Emre, et al. "The effect of liraglutide, a GLP-1 analog, on indomethacin-induced gastric ulcers in diabetic rats.." Acta cirurgica brasileira, 2025. https://doi.org/10.1590/acb407325
RethinkPeptides
RethinkPeptides Research Database. "The effect of liraglutide, a GLP-1 analog, on indomethacin-i..." RPEP-09989. Retrieved from https://rethinkpeptides.com/research/arslan-2025-the-effect-of-liraglutide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.