Neuropeptides and Depression
Explore peptide research and guides on neuropeptides and depression.
Neuropeptides and Depression
CRF and Depression: How a Stress Peptide Drives Mood Disorders
Corticotropin-releasing factor (CRF), a 41-amino-acid stress peptide, is elevated in the cerebrospinal fluid of depressed patients and drives HPA axis hyperactivity.
Neuropeptides and DepressionNeuropeptides and Depression Beyond Serotonin
Neuropeptides like NPY, CRF, substance P, and oxytocin shape depression biology in ways that SSRIs and serotonin-focused treatments miss entirely.
Neuropeptides and DepressionSubstance P Antagonists for Depression
NK1 receptor antagonists showed antidepressant activity equal to SSRIs in early trials, then failed in phase 3. What went wrong and what the story reveals.
Neuropeptides and DepressionVGF-Derived Peptides: A New Antidepressant Target Class
VGF peptide TLQP-62 matched fluoxetine's antidepressant effects in mice through BDNF, not serotonin. Here's the preclinical evidence.