A mitochondria-targeted peptide (SS-31) prevented mitochondrial membrane collapse and apoptosis from oxidative stress, demonstrating that targeting peptides to specific cellular compartments enables precision subcellular therapy.
Key findingSS-31, a cell-permeable peptide targeting the inner mitochondrial membrane, prevented mitochondrial depolarization and apoptosis in neuronal cells exp
What the researchers found
SS-31, a cell-permeable peptide targeting the inner mitochondrial membrane, prevented mitochondrial depolarization and apoptosis in neuronal cells exposed to oxidative stress — demonstrating precision subcellular peptide targeting for protecting the cell's energy source.
Why it matters
Relevant for neuropeptides, neuroprotection, anti-aging, peptide-design.
How the study worked
in-vitro study on neuropeptides, neuroprotection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.
Biochemical pharmacology, 70(12), 1796-806
Citation
Zhao, Kesheng; Luo, Guoxiong; Giannelli, Serena; Szeto, Hazel H. (2005). Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.. Biochemical pharmacology, 70(12), 1796-806.