A Peptide That Targets Mitochondria Prevents Cell Death and Oxidative Damage
A mitochondria-targeted peptide (SS-31) prevented mitochondrial membrane collapse and apoptosis from oxidative stress, demonstrating that targeting peptides to specific cellular compartments enables precision subcellular therapy.
Quick Facts
What This Study Found
SS-31, a cell-permeable peptide targeting the inner mitochondrial membrane, prevented mitochondrial depolarization and apoptosis in neuronal cells exposed to oxidative stress — demonstrating precision subcellular peptide targeting for protecting the cell's energy source.
Key Numbers
How They Did This
in-vitro study on neuropeptides, neuroprotection.
Why This Research Matters
Relevant for neuropeptides, neuroprotection, anti-aging, peptide-design.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding SS-31, a cell-permeable peptide targeting the inner mitochondrial membrane, prevented mitochondrial depolarization and apoptosis in neuronal cells exp
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.
- Published In:
- Biochemical pharmacology, 70(12), 1796-806 (2005)
- Authors:
- Zhao, Kesheng(2), Luo, Guoxiong, Giannelli, Serena, Szeto, Hazel H
- Database ID:
- RPEP-01108
Evidence Hierarchy
Frequently Asked Questions
What was studied?
A Peptide That Targets Mitochondria Prevents Cell Death and Oxidative Damage
What was found?
A mitochondria-targeted peptide (SS-31) prevented mitochondrial membrane collapse and apoptosis from oxidative stress, demonstrating that targeting peptides to specific cellular compartments enables precision subcellular therapy.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01108APA
Zhao, Kesheng; Luo, Guoxiong; Giannelli, Serena; Szeto, Hazel H. (2005). Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.. Biochemical pharmacology, 70(12), 1796-806.
MLA
Zhao, Kesheng, et al. "Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.." Biochemical pharmacology, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Mitochondria-targeted peptide prevents mitochondrial depolar..." RPEP-01108. Retrieved from https://rethinkpeptides.com/research/zhao-2005-mitochondriatargeted-peptide-prevents-mitochondrial
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.